Publications by authors named "Cyrus Bacchi"

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Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.
Andrew M Thompson, Andrew J Marshall, Louis Maes, Nigel Yarlett, Cyrus J Bacchi

Bioorg Med Chem Lett· January 2018

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Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents.
Jean J Vanden Eynde, Annie Mayence, Madhusoodanan Mottamal, Cyrus J Bacchi, Nigel Yarlett

Pharmaceuticals (Basel)· April 2016

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Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities.
Mary C O'Sullivan, Timothy B Durham, Hannah E Valdes, Kelly L Dauer, Nicholas J Karney, Cyrus J Bacchi

Bioorg Med Chem· March 2015

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Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis.
Stephen Wring, Eric Gaukel, Bakela Nare, Robert Jacobs, Beth Beaudet, Cyrus Bacchi

Parasitology· January 2014

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Chemotherapy of human african trypanosomiasis.
Cyrus J Bacchi

Interdiscip Perspect Infect Dis· July 2013

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Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis.
Robert T Jacobs, Jacob J Plattner, Bakela Nare, Stephen A Wring, Daitao Chen, Cyrus J Bacchi

Future Med Chem· August 2011

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SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.
Robert T Jacobs, Bakela Nare, Stephen A Wring, Matthew D Orr, Daitao Chen, Cyrus J Bacchi

PLoS Negl Trop Dis· June 2011

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SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei.
Joe B Perales, Jennifer Freeman, Cyrus J Bacchi, Tana Bowling, Robert Don

Bioorg Med Chem Lett· May 2011

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2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach.
Luke Mercer, Tana Bowling, Joe Perales, Jennifer Freeman, Tien Nguyen, Cyrus Bacchi

PLoS Negl Trop Dis· February 2011

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Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis.
Bakela Nare, Stephen Wring, Cyrus Bacchi, Beth Beaudet, Tana Bowling

Antimicrob Agents Chemother· October 2010

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Discovery of novel benzoxaborole-based potent antitrypanosomal agents.
Dazhong Ding, Yaxue Zhao, Qingqing Meng, Dongsheng Xie, Bakela Nare, Cyrus J Bacchi

ACS Med Chem Lett· July 2010

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Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity.
Tien L Huang, Jean Jacques Vanden Eynde, Annie Mayence, Margaret S Collins, Melanie T Cushion, Cyrus J Bacchi

Bioorg Med Chem Lett· October 2009

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Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor.
Cyrus J Bacchi, Robert H Barker, Aixa Rodriguez, Bradford Hirth, Donna Rattendi

Antimicrob Agents Chemother· August 2009

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Metabolism of an alkyl polyamine analog by a polyamine oxidase from the microsporidian Encephalitozoon cuniculi.
Cyrus J Bacchi, Nigel Yarlett, Evangeline Faciane, Xiangdong Bi, Donna Rattendi

Antimicrob Agents Chemother· June 2009

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Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis.
Robert H Barker, Hanlan Liu, Bradford Hirth, Cassandra A Celatka, Richard Fitzpatrick, Cyrus J Bacchi

Antimicrob Agents Chemother· May 2009

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Novel trypanocidal analogs of 5'-(methylthio)-adenosine.
Janice R Sufrin, Arthur J Spiess, Canio J Marasco, Donna Rattendi, Cyrus J Bacchi

Antimicrob Agents Chemother· January 2008

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Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug.
Tien L Huang, Cyrus J Bacchi, Nageswara R Kode, Qiang Zhang, Guangdi Wang

Int J Antimicrob Agents· December 2007

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Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity.
Xiangdong Bi, Christina Lopez, Cyrus J Bacchi, Donna Rattendi, Patrick M Woster

Bioorg Med Chem Lett· June 2006

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Multiple triclosan targets in Trypanosoma brucei.
Kimberly S Paul, Cyrus J Bacchi, Paul T Englund

Eukaryot Cell· August 2004

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Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues.
Cyrus J Bacchi, Donna Rattendi, Evangeline Faciane, Nigel Yarlett, Louis M Weiss

Microbiology (Reading)· May 2004

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Selective antimicrotubule activity of N1-phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide (GB-II-5) against kinetoplastid parasites.
Karl A Werbovetz, Dan L Sackett, Dawn Delfín, Gautam Bhattacharya, Manar Salem, Cyrus Bacchi

Mol Pharmacol· December 2003

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Trypanocidal activity of conformationally restricted pentamidine congeners.
Isaac O Donkor, Tien L Huang, Bin Tao, Donna Rattendi, Schennella Lane, Cyrus Bacchi

J Med Chem· March 2003

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Trypanocidal diarylheptanoids from Aframomum letestuianum.
Pierre Kamnaing, Apollinaire Tsopmo, Eric A Tanifum, Marguerite H K Tchuendem, Pierre Tane, Cyrus Bacchi

J Nat Prod· March 2003

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Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin.
Slavoljub Vujcic, Paula Diegelman, Cyrus J Bacchi, Debora L Kramer, Carl W Porter

Biochem J· November 2002

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Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity.
Canio J Marasco, Debora L Kramer, John Miller, Carl W Porter, Cyrus J Bacchi

J Med Chem· November 2002

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