Publications by authors named "Timothy B Durham"

Claim this Profile
L
LY3522348, A New Ketohexokinase Inhibitor: A First-in-Human Study in Healthy Adults.
Tsuyoshi Fukuda, Brian R Thompson, Bram Brouwers, Hui-Rong Qian, Wei Wang, Timothy B Durham

Diabetes Ther· July 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification of LY3522348: A Highly Selective and Orally Efficacious Ketohexokinase Inhibitor.
Timothy B Durham, Junliang Hao, Patrick Spinazze, Douglas R Stack, James L Toth

J Med Chem· December 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors.
Rongjun He, Jifeng Wang, Zhi-Hong Yu, Julie S Moyers, M Dodson Michael, Timothy B Durham

J Med Chem· October 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models.
Harold B Brooks, Timothy I Meier, Sandaruwan Geeganage, Kevin R Fales, Kenneth J Thrasher, Timothy B Durham

Sci Rep· October 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis.
Kacey J Prentice, Stacy G Wendell, Ying Liu, Judith A Eversley, Sonia R Salvatore, Timothy B Durham

EBioMedicine· January 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
Kevin R Fales, F George Njoroge, Harold B Brooks, Stefan Thibodeaux, Alicia Torrado, Timothy B Durham

J Med Chem· December 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
O
Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences.
Ana B Bueno, Javier Agejas, Howard Broughton, Robert Dally, Timothy B Durham

J Med Chem· December 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose.
Timothy B Durham, Jothirajah Marimuthu, James L Toth, Chin Liu, Lisa Adams

J Med Chem· July 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis and Characterization of Urofuranoic Acids: In Vivo Metabolism of 2-(2-Carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic Acid (CMPF) and Effects on in Vitro Insulin Secretion.
Edith Nagy, Ying Liu, Kacey J Prentice, Kyle W Sloop, Phillip E Sanders, Timothy B Durham

J Med Chem· March 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
U
Use of Osmotic Pumps to Establish the Pharmacokinetic-Pharmacodynamic Relationship and Define Desirable Human Performance Characteristics for Aggrecanase Inhibitors.
Michael R Wiley, Timothy B Durham, Lisa A Adams, Mark G Chambers, Chaohua Lin

J Med Chem· June 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
Timothy B Durham, James L Toth, Valentine J Klimkowski, Julia X C Cao, Angela M Siesky

J Biol Chem· August 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Target engagement in lead generation.
Timothy B Durham, Maria-Jesus Blanco

Bioorg Med Chem Lett· March 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities.
Mary C O'Sullivan, Timothy B Durham, Hannah E Valdes, Kelly L Dauer, Nicholas J Karney

Bioorg Med Chem· March 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
Timothy B Durham, Valentine J Klimkowski, Christopher J Rito, Jothirajah Marimuthu, James L Toth

J Med Chem· December 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Progress toward the discovery and development of efficacious BACE inhibitors.
Timothy B Durham, Timothy A Shepherd

Curr Opin Drug Discov Devel· November 2006

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Total synthesis of formamicin.
Timothy B Durham, Nicolas Blanchard, Brad M Savall, Noel A Powell, William R Roush

J Am Chem Soc· August 2004

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Stereoselective synthesis of 2-deoxy-beta-galactosides via 2-deoxy-2-bromo- and 2-deoxy-2-iodo-galactopyranosyl donors.
Timothy B Durham, William R Roush

Org Lett· May 2003

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Stereoselective synthesis of functionalized precursors of the CDEF and CDE 2,6-dideoxy-tetra- and trisaccharide units of durhamycins A and B.
Timothy B Durham, William R Roush

Org Lett· May 2003

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Enantioselective synthesis of alpha-amino acids from N-tosyloxy beta-lactams derived from beta-keto esters.
Timothy B Durham, Marvin J Miller

J Org Chem· January 2003

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
An enantioselective synthesis of differentially protected erythro-alpha,beta-diamino acids and its application to the synthesis of an analogue of rhodopeptin B5.
Timothy B Durham, Marvin J Miller

J Org Chem· January 2003

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Conversion of glucuronic acid glycosides to novel bicyclic beta-lactams.
Timothy B Durham, Marvin J Miller

Org Lett· January 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis