Publications by authors named "Kyle W Sloop"

Claim this Profile
L
Long-acting GIPR agonist LY3537021 reduces body weight and fasting blood glucose in patients with T2D: Preclinical development and phase 1 randomized ascending dose studies.
William Roell, Jorge Alsina-Fernandez, Hongchang Qu, Tamer Coskun, Charles Benson, Kyle W Sloop

Mol Metab· December 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Spatially diffuse cAMP signalling with oppositely biased GLP-1 receptor agonists in β-cells despite differences in receptor localisation.
Shiqian Chen, Carolina B Lobato, Carissa Wong, Yusman Manchanda, Katrina Viloria, Kyle W Sloop

Mol Metab· December 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Contrasting roles for GLP-1R and GIPR in a model of diet-induced obesity.
Jie Gao, Shelby Cree, Seungmin Ham, Cameron Nowell, Alex Parker, Kyle W Sloop

J Mol Endocrinol· October 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
Î
α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion.
Canqi Cui, Danielle C Leander, Sarah M Gray, Kimberley El, Alex Chen, Kyle W Sloop

Sci Adv· September 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A Contemporary Rationale for Agonism of the GIP Receptor in the Treatment of Obesity.
Ricardo J Samms, Kyle W Sloop

Diabetes· August 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
Î
β Cell Gαs signaling is critical for physiological and pharmacological enhancement of insulin secretion.
Megan E Capozzi, David Bouslov, Ashot Sargsyan, Michelle Y Chan, Alex Chen, Kyle W Sloop

J Clin Invest· August 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice.
Robert M Gutgesell, Ahmed Khalil, Arkadiusz Liskiewicz, Gandhari Maity-Kumar, Aaron Novikoff, Kyle W Sloop

Nat Metab· June 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Publisher Correction: GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice.
Robert M Gutgesell, Ahmed Khalil, Arkadiusz Liskiewicz, Gandhari Maity-Kumar, Aaron Novikoff, Kyle W Sloop

Nat Metab· June 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
Glucose-dependent insulinotropic polypeptide (GIP).
Timo D Müller, Alice Adriaenssens, Bo Ahrén, Matthias Blüher, Andreas L Birkenfeld, Kyle W Sloop

Mol Metab· May 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The physiological impact of an N-terminal Halo-tag on glucose-dependent insulinotropic polypeptide receptor function in mice.
Iona Davies, Yusman Manchanda, Kyle W Sloop, Stephen R Bloom, Tricia M-M Tan

Diabetes Obes Metab· April 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
functional profiling and structural characterisation of the human A316T variant.
Liliane El Eid, Kieran Deane-Alder, Roxana-Maria Rujan, Zamara Mariam, Affiong I Oqua, Kyle W Sloop

bioRxiv· January 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Characterization of LY3324954 a long-acting glucagon-receptor agonist.
William Roell, Tamer Coskun, Teayoun Kim, Libbey O'Farrell, Jennifer A Martin, Kyle W Sloop

Mol Metab· January 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron.
Kyle W Sloop, Amy L Cox, David B Wainscott, Alex White, Brian A Droz

Sci Transl Med· December 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Class B1 GPCRs: insights into multireceptor pharmacology for the treatment of metabolic disease.
Panjamaporn Sangwung, Joseph D Ho, Tessa Siddall, Jerry Lin, Alejandra Tomas, Kyle W Sloop

Am J Physiol Endocrinol Metab· November 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Effect of Food Consumption on the Pharmacokinetics, Safety, and Tolerability of Once-Daily Orally Administered Orforglipron (LY3502970), a Non-peptide GLP-1 Receptor Agonist.
Xiaosu Ma, Rong Liu, Edward J Pratt, Charles T Benson, Shobha N Bhattachar, Kyle W Sloop

Diabetes Ther· April 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice.
Ellen C Furber, Karissa Hyatt, Kyla Collins, Xinxin Yu, Brian A Droz, Kyle W Sloop

Diabetes· February 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
O
Orforglipron (LY3502970), a novel, oral non-peptide glucagon-like peptide-1 receptor agonist: A Phase 1b, multicentre, blinded, placebo-controlled, randomized, multiple-ascending-dose study in people with type 2 diabetes.
Edward Pratt, Xiaosu Ma, Rong Liu, Deborah Robins, Tamer Coskun, Kyle W Sloop

Diabetes Obes Metab· September 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
O
Orforglipron (LY3502970), a novel, oral non-peptide glucagon-like peptide-1 receptor agonist: A Phase 1a, blinded, placebo-controlled, randomized, single- and multiple-ascending-dose study in healthy participants.
Edward Pratt, Xiaosu Ma, Rong Liu, Deborah Robins, Axel Haupt, Kyle W Sloop

Diabetes Obes Metab· September 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pancreatic islet α cell function and proliferation requires the arginine transporter SLC7A2.
Erick Spears, Jade E Stanley, Matthew Shou, Linlin Yin, Xuan Li, Kyle W Sloop

bioRxiv· August 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets.
Kimberley El, Jonathan D Douros, Francis S Willard, Aaron Novikoff, Ashot Sargsyan, Kyle W Sloop

Nat Metab· June 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue.
Ricardo J Samms, GuoFang Zhang, Wentao He, Olga Ilkayeva, Brian A Droz, Kyle W Sloop

Mol Metab· October 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
L
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept.
Tamer Coskun, Shweta Urva, William C Roell, Hongchang Qu, Corina Loghin, Kyle W Sloop

Cell Metab· September 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior.
Ricardo J Samms, Richard Cosgrove, Brandy M Snider, Ellen C Furber, Brian A Droz, Kyle W Sloop

Diabetes· July 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
1
14-3-3-zeta mediates GLP-1 receptor agonist action to alter α cell proglucagon processing.
Marlena M Holter, Daryl J Phuong, Isaac Lee, Mridusmita Saikia, Lisa Weikert, Kyle W Sloop

Sci Adv· July 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Is Glucagon Receptor Activation the Thermogenic Solution for Treating Obesity?
Ellen Conceição-Furber, Tamer Coskun, Kyle W Sloop, Ricardo J Samms

Front Endocrinol (Lausanne)· May 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis