Publications by authors named "Joseph D Ho"

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Class B1 GPCRs: insights into multireceptor pharmacology for the treatment of metabolic disease.
Panjamaporn Sangwung, Joseph D Ho, Tessa Siddall, Jerry Lin, Alejandra Tomas

Am J Physiol Endocrinol Metab· November 2024

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Structural determinants of dual incretin receptor agonism by tirzepatide.
Bingfa Sun, Francis S Willard, Dan Feng, Jorge Alsina-Fernandez, Qi Chen, Joseph D Ho, Aaron D Showalter

Proc Natl Acad Sci U S A· March 2022

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Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP).
Joseph D Ho, Matthew R Lee, Charles T Rauch, Kristen Aznavour, Jonathan S Park

Biochim Biophys Acta Gen Subj· February 2021

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Structural insights into probe-dependent positive allosterism of the GLP-1 receptor.
Ana B Bueno, Bingfa Sun, Francis S Willard, Dan Feng, Joseph D Ho, Aaron D Showalter

Nat Chem Biol· October 2020

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Discovery and pharmacology of the covalent GLP-1 receptor (GLP-1R) allosteric modulator BETP: A novel tool to probe GLP-1R pharmacology.
Francis S Willard, Joseph D Ho, Kyle W Sloop

Adv Pharmacol· September 2020

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Synthetic protease-activated class B GPCRs.
Francis S Willard, Tamika D Meredith, Aaron D Showalter, Wenzhen Ma, Joseph D Ho

Biochem Biophys Res Commun· September 2020

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Structural Basis for ( S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu Receptor.
Qi Chen, Joseph D Ho, Sheela Ashok, Michelle C Vargas, Jing Wang

J Med Chem· November 2018

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Structural basis for GPR40 allosteric agonism and incretin stimulation.
Joseph D Ho, Betty Chau, Logan Rodgers, Frances Lu, Kelly L Wilbur, Nichole A Reynolds, Christopher Groshong

Nat Commun· April 2018

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Determination of L-AP4-bound human mGlu8 receptor amino terminal domain structure and the molecular basis for L-AP4's group III mGlu receptor functional potency and selectivity.
Jeffery M Schkeryantz, Qi Chen, Joseph D Ho, Shane Atwell, Aiping Zhang

Bioorg Med Chem Lett· February 2018

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3-heterocyclyl quinolone inhibitors of the HCV NS5B polymerase.
Dange V Kumar, Roopa Rai, Ken A Brameld, Jennifer Riggs, John R Somoza, Isabelle Lehoux, Joseph D Ho

Bioorg Med Chem Lett· January 2012

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Immunodominant T cell determinants of aquaporin-4, the autoantigen associated with neuromyelitis optica.
Patricia A Nelson, Mojgan Khodadoust, Thomas Prodhomme, Collin Spencer, Juan Carlos Patarroyo, Joseph D Ho

PLoS One· November 2010

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Function of human Rh based on structure of RhCG at 2.1 A.
Franz Gruswitz, Sarika Chaudhary, Joseph D Ho, Avner Schlessinger, Bobak Pezeshki, Chi-Min Ho, Connie M Westhoff

Proc Natl Acad Sci U S A· May 2010

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A general protocol for the crystallization of membrane proteins for X-ray structural investigation.
Zachary E R Newby, Joseph D O'Connell, Franz Gruswitz, Franklin A Hays, William E C Harries, Joseph D Ho

Nat Protoc· June 2009

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Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance.
Joseph D Ho, Ronald Yeh, Andrew Sandstrom, Ilya Chorny, William E C Harries

Proc Natl Acad Sci U S A· May 2009

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The crystal structure of E. coli rRNA pseudouridine synthase RluE.
Hu Pan, Joseph D Ho, Robert M Stroud, Janet Finer-Moore

J Mol Biol· April 2007

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Structure-guided design of peptide-based tryptase inhibitors.
Mary E McGrath, Paul A Sprengeler, Bernard Hirschbein, John R Somoza, Isabelle Lehoux, Joseph D Ho

Biochemistry· May 2006

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Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity.
Jen-Chywan Wang, Nilesh Shah, Carlos Pantoja, Sebastiaan H Meijsing, Joseph D Ho, Thomas S Scanlan

Genes Dev· March 2006

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Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
Bradley A Katz, Christine Luong, Joseph D Ho, John R Somoza, Erik Gjerstad

J Mol Biol· November 2004

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Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases.
John R Somoza, Robert J Skene, Bradley A Katz, Clifford Mol, Joseph D Ho

Structure· July 2004

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The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.
John R Somoza, Joseph D Ho, Christine Luong, Manjiri Ghate, Paul A Sprengeler

Structure· September 2003

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Expression, purification, crystallization and preliminary X-ray diffraction studies of human cathepsin F complexed with an irreversible vinyl sulfone inhibitor.
Joseph D Ho, Yana Meltser, Joseph J Buggy, James T Palmer, Kyle C Elrod

Acta Crystallogr D Biol Crystallogr· December 2002

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The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators.
John R Somoza, James T Palmer, Joseph D Ho

J Mol Biol· September 2002

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