Publications by authors named "Manjiri Ghate"

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De novo fragment design: a medicinal chemistry approach to fragment-based lead generation.
Francisco X Talamas, Gloria Ao-Ieong, Ken A Brameld, Elbert Chin, Javier de Vicente, Manjiri Ghate

J Med Chem· April 2013

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3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: design and development to a highly selective lead.
Michael Soth, Sarah Abbot, Allassan Abubakari, Nidhi Arora, Humberto Arzeno, Manjiri Ghate

Bioorg Med Chem Lett· June 2011

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Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase.
David M Goldstein, Michael Soth, Tobias Gabriel, Nolan Dewdney, Andreas Kuglstatter, Manjiri Ghate

J Med Chem· April 2011

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X-ray crystal structure of JNK2 complexed with the p38alpha inhibitor BIRB796: insights into the rational design of DFG-out binding MAP kinase inhibitors.
Andreas Kuglstatter, Manjiri Ghate, Stan Tsing, Armando G Villaseñor, David Shaw

Bioorg Med Chem Lett· September 2010

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Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids.
Javier de Vicente, Robert T Hendricks, David B Smith, Jay B Fell, John Fischer, Manjiri Ghate

Bioorg Med Chem Lett· October 2009

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Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones.
Javier de Vicente, Robert T Hendricks, David B Smith, Jay B Fell, John Fischer, Manjiri Ghate

Bioorg Med Chem Lett· July 2009

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The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.
John R Somoza, Joseph D Ho, Christine Luong, Manjiri Ghate, Paul A Sprengeler

Structure· September 2003

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