Publications by authors named "David B Smith"

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Discovery and Preclinical Profile of ALG-097558, a Pan-Coronavirus 3CLpro Inhibitor.
Dorothée Bardiot, David C McGowan, Kusum Gupta, Jerome Deval, Sandra Chang, David B Smith

J Med Chem· July 2025

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The Death of Jean Cowsert, MD, and the Future of Medicare.
David Barton Smith

Am J Med· June 2025

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The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075.
Sandrine Vendeville, Franck Amblard, Leda Bassit, Leonid N Beigelman, Lawrence M Blatt, David B Smith

J Med Chem· December 2024

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Multi-institutional report of trastuzumab deruxtecan and stereotactic radiosurgery for HER2 positive and HER2-low breast cancer brain metastases.
Vaseem M Khatri, Mariella A Mestres-Villanueva, Sreenija Yarlagadda, Ajay Doniparthi, David B Smith

NPJ Breast Cancer· November 2024

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Restorative Justice: The Life and Death of Jean Cowsert, MD.
David Barton Smith

Am J Med· June 2024

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An in vivo duck hepatitis B virus model recapitulates key aspects of nucleic acid polymer treatment outcomes in chronic hepatitis B patients.
Yannick Debing, Hannah Vanrusselt, Lars Degrauwe, Daniel Apolônio Silva de Oliveira, Christopher Kinyanjui Kariuki, David B Smith

Antiviral Res· April 2024

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Synthesis and evaluation of highly potent HBV capsid assembly modulators (CAMs).
Franck Amblard, Zhe Chen, John Wiseman, Shaoman Zhou, Peng Liu, David B Smith

Bioorg Chem· December 2023

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Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models.
Andreas Jekle, Santosh Kumar Thatikonda, Ruchika Jaisinghani, Suping Ren, April Kinkade, David B Smith

Int J Mol Sci· November 2023

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Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules.
C Cheng Kao, Yuchun Nie, Suping Ren, N Tilani T S De Costa, Rajendra K Pandey, David B Smith

Mol Ther Nucleic Acids· March 2022

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Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C.
Guangyi Wang, Natalia Dyatkina, Marija Prhavc, Caroline Williams, Vladimir Serebryany, David B Smith

J Med Chem· September 2020

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The Pandemic Challenge: End Separate and Unequal Healthcare.
David Barton Smith

Am J Med Sci· August 2020

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Learning and generalization of within-category representations in a rule-based category structure.
Shawn W Ell, David B Smith, Rose Deng, Sébastien Hélie

Atten Percept Psychophys· July 2020

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Hybrid hollow silica particles: synthesis and comparison of properties with pristine particles.
Jaswinder Sharma, David A Cullen, Georgios Polizos, Kashif Nawaz, Hsin Wang, David Barton Smith

RSC Adv· June 2020

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A modern reassessment of glycoprotein-specific direct platelet autoantibody testing in immune thrombocytopenia.
Hanny Al-Samkari, Rachel P Rosovsky, Rebecca S Karp Leaf, David B Smith, Katayoon Goodarzi

Blood Adv· January 2020

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Synthesis and Anti-HCV Activities of 4'-Fluoro-2'-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4'-Fluoro-2'- C-methyluridine 5'-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection.
Guangyi Wang, Natalia Dyatkina, Marija Prhavc, Caroline Williams, Vladimir Serebryany, David B Smith

J Med Chem· May 2019

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Pharmacokinetics, safety, and tolerability of the 2- and 3-direct-acting antiviral combination of AL-335, odalasvir, and simeprevir in healthy subjects.
Thomas N Kakuda, Matthew W McClure, Christopher Westland, Jennifer Vuong, Marie-Claude Homery, David B Smith

Pharmacol Res Perspect· June 2018

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Channel Deviation-Based Power Control in Body Area Networks.
Son Dinh Van, Simon L Cotton, David B Smith

IEEE J Biomed Health Inform· May 2018

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The impact of category structure and training methodology on learning and generalizing within-category representations.
Shawn W Ell, David B Smith, Gabriela Peralta, Sébastien Hélie

Atten Percept Psychophys· August 2017

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Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs.
Zhinan Jin, April Kinkade, Ishani Behera, Shuvam Chaudhuri, Kathryn Tucker, David B Smith

Antiviral Res· July 2017

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Nebulized Fentanyl for Dyspnea in a Hospice Patient with True Allergy to Morphine and Hydromorphone.
Robert G Wahler, David B Smith, Kimberly B Mulcahy

J Pain Palliat Care Pharmacother· March 2017

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Surface-air mercury fluxes across Western North America: A synthesis of spatial trends and controlling variables.
Chris S Eckley, Mike T Tate, Che-Jen Lin, Mae Gustin, Stephen Dent, Collin Eagles-Smith, David B Smith

Sci Total Environ· October 2016

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Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C-Nucleosides as Favipiravir (T-705) Analogues.
Guangyi Wang, Jinqiao Wan, Yujian Hu, Xiangyang Wu, Marija Prhavc, David B Smith

J Med Chem· May 2016

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Intramolecular Hydrogen-Bonding Effects on the Fluorescence of PRODAN Derivatives.
Isaac G Alty, Douglas W Cheek, Tao Chen, David B Smith, Emma Q Walhout

J Phys Chem A· May 2016

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Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate.
Jerome Deval, Jin Hong, Guangyi Wang, Josh Taylor, Lucas K Smith, David B Smith

PLoS Pathog· June 2015

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Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection.
Guangyi Wang, Jerome Deval, Jin Hong, Natalia Dyatkina, Marija Prhavc, David B Smith

J Med Chem· February 2015

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