Publications by authors named "Jerome Deval"

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Discovery and Preclinical Profile of ALG-097558, a Pan-Coronavirus 3CLpro Inhibitor.
Dorothée Bardiot, David C McGowan, Kusum Gupta, Jerome Deval, Sandra Chang

J Med Chem· July 2025

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The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075.
Sandrine Vendeville, Franck Amblard, Leda Bassit, Leonid N Beigelman, Lawrence M Blatt, Jerome Deval

J Med Chem· December 2024

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Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH.
Koen Vandyck, David C McGowan, Xuan G Luong, Sarah K Stevens, Andreas Jekle, Jerome Deval

J Med Chem· September 2024

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JNJ-7184, a respiratory syncytial virus inhibitor targeting the connector domain of the viral polymerase.
Brecht Bonneux, Afzaal Shareef, Sergey Tcherniuk, Brandon Anson, Suzanne de Bruyn, Jerome Deval

Antiviral Res· July 2024

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Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models.
Andreas Jekle, Santosh Kumar Thatikonda, Ruchika Jaisinghani, Suping Ren, April Kinkade, Jerome Deval

Int J Mol Sci· November 2023

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Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation.
Dieudonné Buh Kum, Hannah Vanrusselt, Abel Acosta Sanchez, Valerio Taverniti, Eloi R Verrier, Jerome Deval

Hepatology· October 2023

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Novel non-HAP class A HBV capsid assembly modulators have distinct and profiles.
Hannah Vanrusselt, Dieudonné Buh Kum, Valerio Taverniti, Cheng Liu, Abel Acosta Sanchez, Jerome Deval

J Virol· October 2023

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Meeting report: 35th International Conference on Antiviral Research in Seattle, Washington, USA - March 21-25, 2022.
Jessica R Spengler, Stephen R Welch, Jerome Deval, Brian G Gentry, Andrea Brancale

Antiviral Res· March 2023

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The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor and Confer Resistance To Nirmatrelvir.
Dirk Jochmans, Cheng Liu, Kim Donckers, Antitsa Stoycheva, Sandro Boland, Jerome Deval

mBio· February 2023

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Meeting report: 34th international conference on antiviral research.
Andrea Brancale, Kara Carter, Leen Delang, Jerome Deval, David Durantel

Antivir Chem Chemother· October 2022

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Opportunities and Challenges in Targeting the Proofreading Activity of SARS-CoV-2 Polymerase Complex.
Jerome Deval, Zachary A Gurard-Levin

Molecules· May 2022

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Comparison of RNA synthesis initiation properties of non-segmented negative strand RNA virus polymerases.
Afzaal M Shareef, Barbara Ludeke, Paul Jordan, Jerome Deval, Rachel Fearns

PLoS Pathog· December 2021

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Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection.
Koen Vandyck, Jerome Deval

Curr Opin Virol· August 2021

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Label-Free Screening of SARS-CoV-2 NSP14 Exonuclease Activity Using SAMDI Mass Spectrometry.
Michael D Scholle, Cheng Liu, Jerome Deval, Zachary A Gurard-Levin

SLAS Discov· July 2021

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ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
Koen Vandyck, Rana Abdelnabi, Kusum Gupta, Dirk Jochmans, Andreas Jekle, Jerome Deval

Biochem Biophys Res Commun· May 2021

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Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development.
Cheng Liu, Sandro Boland, Michael D Scholle, Dorothee Bardiot, Arnaud Marchand, Jerome Deval

Antiviral Res· March 2021

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Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH).
Xuan G Luong, Sarah K Stevens, Andreas Jekle, Tse-I Lin, Kusum Gupta, Jerome Deval

PLoS One· January 2021

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Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry.
Zachary A Gurard-Levin, Cheng Liu, Andreas Jekle, Ruchika Jaisinghani, Suping Ren, Jerome Deval

Antiviral Res· October 2020

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Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C.
Guangyi Wang, Natalia Dyatkina, Marija Prhavc, Caroline Williams, Vladimir Serebryany, Jerome Deval

J Med Chem· September 2020

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Nucleosides for the treatment of respiratory RNA virus infections.
Paul C Jordan, Sarah K Stevens, Jerome Deval

Antivir Chem Chemother· June 2019

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Advances in antiviral nucleoside analogues and their prodrugs.
Katherine Seley-Radtke, Jerome Deval

Antivir Chem Chemother· June 2019

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Synthesis and Anti-HCV Activities of 4'-Fluoro-2'-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4'-Fluoro-2'- C-methyluridine 5'-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection.
Guangyi Wang, Natalia Dyatkina, Marija Prhavc, Caroline Williams, Vladimir Serebryany, Jerome Deval

J Med Chem· May 2019

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Innovation and trends in the development and approval of antiviral medicines: 1987-2017 and beyond.
Shuvam Chaudhuri, Julian A Symons, Jerome Deval

Antiviral Res· July 2018

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Susceptibility of paramyxoviruses and filoviruses to inhibition by 2'-monofluoro- and 2'-difluoro-4'-azidocytidine analogs.
Michael K Lo, Paul C Jordan, Sarah Stevens, Yuen Tam, Jerome Deval

Antiviral Res· May 2018

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Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase.
Paul C Jordan, Cheng Liu, Pauline Raynaud, Michael K Lo, Christina F Spiropoulou, Jerome Deval

PLoS Pathog· February 2018

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