Publications by authors named "Tse-I Lin"

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A Phase 1 study of the safety, tolerability, and pharmacokinetics of ALG-000184 (pevifoscorvir sodium), a novel Class E capsid assembly modulator, in healthy participants.
Ed Gane, Christian Schwabe, Min Wu, Tse-I Lin, Lawrence Blatt

Antivir Ther· December 2025

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A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG-055009, a novel thyroid hormone receptor beta (THR-β) agonist for metabolic dysfunction-associated steatohepatitis (MASH), in healthy participants.
Hakim Charfi, Benedetta Massetto, Megan Fitzgerald, Kha Le, Stanley Wang, Tse-I Lin

Clin Pharmacol Drug Dev· September 2025

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Discovery and Preclinical Profile of ALG-097558, a Pan-Coronavirus 3CLpro Inhibitor.
Dorothée Bardiot, David C McGowan, Kusum Gupta, Jerome Deval, Sandra Chang, Tse-I Lin

J Med Chem· July 2025

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Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH.
Koen Vandyck, David C McGowan, Xuan G Luong, Sarah K Stevens, Andreas Jekle, Caroline Williams, Tse-I Lin

J Med Chem· September 2024

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An in vivo duck hepatitis B virus model recapitulates key aspects of nucleic acid polymer treatment outcomes in chronic hepatitis B patients.
Yannick Debing, Hannah Vanrusselt, Lars Degrauwe, Daniel Apolônio Silva de Oliveira, Christopher Kinyanjui Kariuki, Tse-I Lin

Antiviral Res· April 2024

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JNJ-64794964 (AL-034/TQ-A3334), a TLR7 agonist, induces sustained anti-HBV activity in AAV/HBV mice via non-cytolytic mechanisms.
Florence Herschke, Chris Li, Ren Zhu, Qinglin Han, Qun Wu, Tse-I Lin

Antiviral Res· December 2021

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Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH).
Xuan G Luong, Sarah K Stevens, Andreas Jekle, Tse-I Lin, Kusum Gupta, Caroline Williams

PLoS One· January 2021

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Discovery of 1-((2R,4aR,6R,7R,7aR)-2-Isopropoxy-2-oxidodihydro-4H,6H-spiro[furo[3,2-d][1,3,2]dioxaphosphinine-7,2'-oxetan]-6-yl)pyrimidine-2,4(1H,3H)-dione (JNJ-54257099), a 3'-5'-Cyclic Phosphate Ester Prodrug of 2'-Deoxy-2'-Spirooxetane Uridine Triphosphate Useful for HCV Inhibition.
Tim H M Jonckers, Abdellah Tahri, Leen Vijgen, Jan Martin Berke, Sophie Lachau-Durand, Tse-I Lin

J Med Chem· June 2016

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Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase.
Maxwell D Cummings, Tse-I Lin, Lili Hu, Abdellah Tahri, David McGowan

J Med Chem· March 2014

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Nucleotide prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides as novel inhibitors of the HCV NS5B polymerase.
Tim H M Jonckers, Koen Vandyck, Leen Vandekerckhove, Lili Hu, Abdellah Tahri, Tse-I Lin

J Med Chem· March 2014

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TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage.
Benoit Devogelaere, Jan Martin Berke, Leen Vijgen, Pascale Dehertogh, Els Fransen, Tse-I Lin

Antimicrob Agents Chemother· September 2012

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Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series.
David McGowan, Sandrine Vendeville, Tse-I Lin, Abdellah Tahri, Lili Hu

Bioorg Med Chem Lett· July 2012

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Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055.
Sandrine Vendeville, Tse-I Lin, Lili Hu, Abdellah Tahri, David McGowan

Bioorg Med Chem Lett· July 2012

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Discovery of 4'-azido-2'-deoxy-2'-C-methyl cytidine and prodrugs thereof: a potent inhibitor of Hepatitis C virus replication.
Magnus Nilsson, Genadiy Kalayanov, Anna Winqvist, Pedro Pinho, Christian Sund, Horst Wähling, Anneli Lindqvist, Tse-I Lin

Bioorg Med Chem Lett· May 2012

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Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.
Maxwell D Cummings, Tse-I Lin, Lili Hu, Abdellah Tahri, David McGowan

Angew Chem Int Ed Engl· May 2012

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Antiviral activity and mode of action of TMC647078, a novel nucleoside inhibitor of the hepatitis C virus NS5B polymerase.
Jan Martin Berke, Leen Vijgen, Sophie Lachau-Durand, Megan H Powdrill, Svea Rawe, Tse-I Lin

Antimicrob Agents Chemother· August 2011

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Tracking the evolution of multiple in vitro hepatitis C virus replicon variants under protease inhibitor selection pressure by 454 deep sequencing.
Thierry Verbinnen, Herwig Van Marck, Ina Vandenbroucke, Leen Vijgen, Marijke Claes, Tse-I Lin

J Virol· November 2010

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2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase.
Tim H M Jonckers, Tse-I Lin, Christophe Buyck, Sophie Lachau-Durand, Koen Vandyck

J Med Chem· November 2010

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Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: exploration of P2 quinazoline substituents.
Magnus Nilsson, Anna Karin Belfrage, Stefan Lindström, Horst Wähling, Charlotta Lindquist, Elizabeth Hamelink, Tse-I Lin

Bioorg Med Chem Lett· July 2010

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Development of a high-content screening assay to identify compounds interfering with the formation of the hepatitis C virus replication complex.
Jan Martin Berke, Denis Fenistein, Frederik Pauwels, Rob Bobbaers, Oliver Lenz, Tse-I Lin

J Virol Methods· May 2010

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In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435.
Oliver Lenz, Thierry Verbinnen, Tse-I Lin, Leen Vijgen, Maxwell D Cummings, Jimmy Lindberg

Antimicrob Agents Chemother· May 2010

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Mechanism and specificity of a symmetrical benzimidazolephenylcarboxamide helicase inhibitor.
Craig A Belon, Yoji D High, Tse-I Lin, Frederik Pauwels, David N Frick

Biochemistry· March 2010

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Induced-fit binding of the macrocyclic noncovalent inhibitor TMC435 to its HCV NS3/NS4A protease target.
Maxwell D Cummings, Jimmy Lindberg, Tse-I Lin, Herman de Kock, Oliver Lenz

Angew Chem Int Ed Engl· February 2010

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1,5-Benzodiazepine inhibitors of HCV NS5B polymerase.
David McGowan, Origène Nyanguile, Maxwell D Cummings, Sandrine Vendeville, Koen Vandyck, Tse-I Lin

Bioorg Med Chem Lett· May 2009

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In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor.
Tse-I Lin, Oliver Lenz, Gregory Fanning, Thierry Verbinnen, Frédéric Delouvroy

Antimicrob Agents Chemother· April 2009

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