Publications by authors named "Els Fransen"

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Evaluation of Cytologic Sample Preparations for Compatibility With Nucleic Acid Analysis.
Laure Sorber, Bart Claes, Karen Zwaenepoel, Bieke Van Dorst, Koen De Winne, Els Fransen

Am J Clin Pathol· February 2022

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Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase.
Maxwell D Cummings, Tse-I Lin, Lili Hu, Abdellah Tahri, David McGowan, Els Fransen

J Med Chem· March 2014

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TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage.
Benoit Devogelaere, Jan Martin Berke, Leen Vijgen, Pascale Dehertogh, Els Fransen

Antimicrob Agents Chemother· September 2012

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Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series.
David McGowan, Sandrine Vendeville, Tse-I Lin, Abdellah Tahri, Lili Hu, Els Fransen

Bioorg Med Chem Lett· July 2012

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Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055.
Sandrine Vendeville, Tse-I Lin, Lili Hu, Abdellah Tahri, David McGowan, Els Fransen

Bioorg Med Chem Lett· July 2012

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Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.
Maxwell D Cummings, Tse-I Lin, Lili Hu, Abdellah Tahri, David McGowan, Els Fransen

Angew Chem Int Ed Engl· May 2012

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Antiviral activity and mode of action of TMC647078, a novel nucleoside inhibitor of the hepatitis C virus NS5B polymerase.
Jan Martin Berke, Leen Vijgen, Sophie Lachau-Durand, Megan H Powdrill, Svea Rawe, Els Fransen

Antimicrob Agents Chemother· August 2011

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In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435.
Oliver Lenz, Thierry Verbinnen, Tse-I Lin, Leen Vijgen, Maxwell D Cummings, Els Fransen

Antimicrob Agents Chemother· May 2010

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TMC125 displays a high genetic barrier to the development of resistance: evidence from in vitro selection experiments.
Johan Vingerhoets, Hilde Azijn, Els Fransen, Inky De Baere, Liesbet Smeulders

J Virol· October 2005

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