Publications by authors named "Gregory Fanning"

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Noninvasive chimeric DNA profiling identifies tumor-originated HBV integrants contributing to viral antigen expression in liver cancer.
Wei Chen, Ke Zhang, Peiling Dong, Gregory Fanning, Chengcheng Tao

Hepatol Int· May 2020

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Author Correction: Therapeutic strategies for hepatitis B virus infection: towards a cure.
Gregory C Fanning, Fabien Zoulim, Jinlin Hou, Antonio Bertoletti

Nat Rev Drug Discov· April 2020

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Therapeutic strategies for hepatitis B virus infection: towards a cure.
Gregory C Fanning, Fabien Zoulim, Jinlin Hou, Antonio Bertoletti

Nat Rev Drug Discov· November 2019

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A Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer.
Xi Li, Rouzheng Wang, Peiwen Fan, Xuan Yao, Ling Qin, Gregory Fanning

Front Oncol· October 2019

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TSD: A Computational Tool To Study the Complex Structural Variants Using PacBio Targeted Sequencing Data.
Guofeng Meng, Ying Tan, Yue Fan, Yan Wang, Guang Yang, Gregory Fanning

G3 (Bethesda)· May 2019

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Design and synthesis of tetrahydropyridopyrimidine based Toll-Like Receptor (TLR) 7/8 dual agonists.
David C McGowan, Florence Herschke, Mourad D Khamlichi, Mari Luz Rosauro, Sara M Pérez Benedicto, Gregory Fanning

Bioorg Med Chem Lett· October 2018

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2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B Virus.
Werner Embrechts, Florence Herschke, Frederik Pauwels, Bart Stoops, Stefaan Last, Gregory Fanning

J Med Chem· July 2018

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Discovery of selective 2,4-diaminoquinazoline toll-like receptor 7 (TLR 7) agonists.
Serge Pieters, David McGowan, Florence Herschke, Frederik Pauwels, Bart Stoops, Gregory Fanning

Bioorg Med Chem Lett· February 2018

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Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B.
David C McGowan, Florence Herschke, Frederik Pauwels, Bart Stoops, Ilham Smyej, Gregory Fanning

J Med Chem· July 2017

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Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus.
David McGowan, Florence Herschke, Frederik Pauwels, Bart Stoops, Stefaan Last, Gregory Fanning

J Med Chem· September 2016

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High MIG (CXCL9) plasma levels favours response to peginterferon and ribavirin in HCV-infected patients regardless of DPP4 activity.
Susanne Johansson, Willem Talloen, Marianne Tuefferd, Jama Darling, Gregory Fanning

Liver Int· March 2016

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Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase.
Maxwell D Cummings, Tse-I Lin, Lili Hu, Abdellah Tahri, David McGowan, Gregory Fanning

J Med Chem· March 2014

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Nucleotide prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides as novel inhibitors of the HCV NS5B polymerase.
Tim H M Jonckers, Koen Vandyck, Leen Vandekerckhove, Lili Hu, Abdellah Tahri, Gregory Fanning

J Med Chem· March 2014

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A cellular replicon-based phenotyping assay to determine susceptibility of hepatitis C virus clinical isolates to NS3/4A protease inhibitors.
Leen Vijgen, Jannick Verbeeck, Barbara Van Kerckhove, Jan Martin Berke, Diana Koletzki, Gregory Fanning

Methods Mol Biol· January 2014

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Replication capacity of minority variants in viral populations can affect the assessment of resistance in HCV chimeric replicon phenotyping assays.
Thierry Verbinnen, Tom Jacobs, Leen Vijgen, Hugo Ceulemans, Johan Neyts, Gregory Fanning

J Antimicrob Chemother· October 2012

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TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage.
Benoit Devogelaere, Jan Martin Berke, Leen Vijgen, Pascale Dehertogh, Els Fransen, Gregory C Fanning

Antimicrob Agents Chemother· September 2012

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Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series.
David McGowan, Sandrine Vendeville, Tse-I Lin, Abdellah Tahri, Lili Hu, Gregory Fanning

Bioorg Med Chem Lett· July 2012

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Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055.
Sandrine Vendeville, Tse-I Lin, Lili Hu, Abdellah Tahri, David McGowan, Gregory Fanning

Bioorg Med Chem Lett· July 2012

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Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.
Maxwell D Cummings, Tse-I Lin, Lili Hu, Abdellah Tahri, David McGowan, Gregory Fanning

Angew Chem Int Ed Engl· May 2012

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Antiviral activity and mode of action of TMC647078, a novel nucleoside inhibitor of the hepatitis C virus NS5B polymerase.
Jan Martin Berke, Leen Vijgen, Sophie Lachau-Durand, Megan H Powdrill, Svea Rawe, Gregory C Fanning

Antimicrob Agents Chemother· August 2011

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The effects of stem length and core placement on shRNA activity.
Glen J McIntyre, Yi-Hsin Yu, Mehnaaz Lomas, Gregory C Fanning

BMC Mol Biol· August 2011

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A comparison of multiple shRNA expression methods for combinatorial RNAi.
Glen J McIntyre, Allison J Arndt, Kirsten M Gillespie, Wendy M Mak, Gregory C Fanning

Genet Vaccines Ther· April 2011

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Quantitation of pretreatment serum interferon-γ-inducible protein-10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response.
Jama M Darling, Jeroen Aerssens, Gregory Fanning, John G McHutchison, David B Goldstein

Hepatology· January 2011

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Tracking the evolution of multiple in vitro hepatitis C virus replicon variants under protease inhibitor selection pressure by 454 deep sequencing.
Thierry Verbinnen, Herwig Van Marck, Ina Vandenbroucke, Leen Vijgen, Marijke Claes, Gregory Fanning

J Virol· November 2010

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2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase.
Tim H M Jonckers, Tse-I Lin, Christophe Buyck, Sophie Lachau-Durand, Koen Vandyck, Gregory Fanning

J Med Chem· November 2010

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