Publications by authors named "Stefaan Last"

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Discovery of Gut-Restricted PRMT5 Inhibitors to Intercept Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor Adenomatous Polyposis Coli.
Fabian Hulpia, Wim Schepens, Susan Lepri, Johan Nicolaï, Zhengyu Jiang, Stefaan Last

J Med Chem· November 2025

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Enabling electrochemical, decarboxylative C(sp)-C(sp) cross-coupling for parallel medicinal chemistry.
Jennifer Morvan, Bingqing Tang, Pavel Ryabchuk, Evelien Renders, Stefaan Last

Eur J Med Chem· July 2025

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Enabling Deoxygenative C(sp)-C(sp) Cross-Coupling for Parallel Medicinal Chemistry.
Wei Liu, James Mulhearn, Bo Hao, Santiago Cañellas, Stefaan Last

ACS Med Chem Lett· June 2023

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2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B Virus.
Werner Embrechts, Florence Herschke, Frederik Pauwels, Bart Stoops, Stefaan Last

J Med Chem· July 2018

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Discovery of selective 2,4-diaminoquinazoline toll-like receptor 7 (TLR 7) agonists.
Serge Pieters, David McGowan, Florence Herschke, Frederik Pauwels, Bart Stoops, Stefaan Last

Bioorg Med Chem Lett· February 2018

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Characterization of a dengue NS4B inhibitor originating from an HCV small molecule library.
Ilane Hernandez-Morales, Peggy Geluykens, Marleen Clynhens, Rudy Strijbos, Olivia Goethals, Stefaan Last

Antiviral Res· November 2017

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Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B.
David C McGowan, Florence Herschke, Frederik Pauwels, Bart Stoops, Ilham Smyej, Stefaan Last

J Med Chem· July 2017

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Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus.
David McGowan, Florence Herschke, Frederik Pauwels, Bart Stoops, Stefaan Last

J Med Chem· September 2016

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Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase.
Maxwell D Cummings, Tse-I Lin, Lili Hu, Abdellah Tahri, David McGowan, Stefaan Last

J Med Chem· March 2014

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Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series.
David McGowan, Sandrine Vendeville, Tse-I Lin, Abdellah Tahri, Lili Hu, Stefaan Last

Bioorg Med Chem Lett· July 2012

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Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055.
Sandrine Vendeville, Tse-I Lin, Lili Hu, Abdellah Tahri, David McGowan, Stefaan Last

Bioorg Med Chem Lett· July 2012

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Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.
Maxwell D Cummings, Tse-I Lin, Lili Hu, Abdellah Tahri, David McGowan, Stefaan Last

Angew Chem Int Ed Engl· May 2012

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Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase.
Koen Vandyck, Maxwell D Cummings, Origène Nyanguile, Carlo W Boutton, Sandrine Vendeville, Stefaan Last

J Med Chem· July 2009

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1,5-Benzodiazepine inhibitors of HCV NS5B polymerase.
David McGowan, Origène Nyanguile, Maxwell D Cummings, Sandrine Vendeville, Koen Vandyck, Stefaan Last

Bioorg Med Chem Lett· May 2009

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