Publications by authors named "Aaron D Showalter"

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The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron.
Kyle W Sloop, Amy L Cox, David B Wainscott, Alex White, Brian A Droz, Aaron D Showalter

Sci Transl Med· December 2024

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Structural determinants of dual incretin receptor agonism by tirzepatide.
Bingfa Sun, Francis S Willard, Dan Feng, Jorge Alsina-Fernandez, Qi Chen, Aaron D Showalter

Proc Natl Acad Sci U S A· March 2022

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Discovery of an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide-1 Receptor.
Francis S Willard, David B Wainscott, Aaron D Showalter, Cynthia Stutsman, Wenzhen Ma

J Med Chem· March 2021

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Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist.
Takahiro Kawai, Bingfa Sun, Hitoshi Yoshino, Dan Feng, Yoshiyuki Suzuki, Aaron D Showalter

Proc Natl Acad Sci U S A· November 2020

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Structural insights into probe-dependent positive allosterism of the GLP-1 receptor.
Ana B Bueno, Bingfa Sun, Francis S Willard, Dan Feng, Joseph D Ho, Aaron D Showalter

Nat Chem Biol· October 2020

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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.
Francis S Willard, Jonathan D Douros, Maria Bn Gabe, Aaron D Showalter, David B Wainscott

JCI Insight· September 2020

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Synthetic protease-activated class B GPCRs.
Francis S Willard, Tamika D Meredith, Aaron D Showalter, Wenzhen Ma, Joseph D Ho

Biochem Biophys Res Commun· September 2020

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Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles.
Ana B Bueno, Aaron D Showalter, David B Wainscott, Cynthia Stutsman, Aranzazu Marín

J Biol Chem· May 2016

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Correction: A Novel Humanized GLP-1 Receptor Model Enables Both Affinity Purification and Cre-LoxP Deletion of the Receptor.
Lucy S Jun, Aaron D Showalter, Nosher Ali, Feihan Dai, Wenzhen Ma

PLoS One· September 2015

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Glucagon-like peptide-1 receptor ligand interactions: structural cross talk between ligands and the extracellular domain.
Graham M West, Francis S Willard, Kyle W Sloop, Aaron D Showalter, Bruce D Pascal

PLoS One· May 2015

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Absence of glucagon and insulin action reveals a role for the GLP-1 receptor in endogenous glucose production.
Lucy S Jun, Rohn L Millican, Eric D Hawkins, Debra L Konkol, Aaron D Showalter

Diabetes· March 2015

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A novel humanized GLP-1 receptor model enables both affinity purification and Cre-LoxP deletion of the receptor.
Lucy S Jun, Aaron D Showalter, Nosher Ali, Feihan Dai, Wenzhen Ma

PLoS One· January 2015

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Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.
Ming Zhang, Mélanie Robitaille, Aaron D Showalter, Xinyi Huang, Ying Liu

Mol Cell Proteomics· November 2014

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Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin.
Francis S Willard, Denise Wootten, Aaron D Showalter, Emilia E Savage, James Ficorilli

Mol Pharmacol· December 2012

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Allosteric modulation of endogenous metabolites as an avenue for drug discovery.
Denise Wootten, Emilia E Savage, Celine Valant, Lauren T May, Kyle W Sloop, Aaron D Showalter

Mol Pharmacol· August 2012

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Model of pediatric pituitary hormone deficiency separates the endocrine and neural functions of the LHX3 transcription factor in vivo.
Stephanie C Colvin, Raleigh E Malik, Aaron D Showalter, Kyle W Sloop, Simon J Rhodes

Proc Natl Acad Sci U S A· January 2011

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Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets.
Kyle W Sloop, Francis S Willard, Martin B Brenner, James Ficorilli, Kathleen Valasek, Aaron D Showalter

Diabetes· December 2010

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Suppression of choroid plexus transthyretin levels by antisense oligonucleotide treatment.
Merrill D Benson, Richard A Smith, Gene Hung, Barbara Kluve-Beckerman, Aaron D Showalter

Amyloid· June 2010

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Specific reduction of hepatic glucose 6-phosphate transporter-1 ameliorates diabetes while avoiding complications of glycogen storage disease.
Kyle W Sloop, Aaron D Showalter, Amy L Cox, Julia X C Cao, Angela M Siesky

J Biol Chem· June 2007

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Targeted suppression of an amyloidogenic transthyretin with antisense oligonucleotides.
Merrill D Benson, Barbara Kluve-Beckerman, Steven R Zeldenrust, Angela M Siesky, Diane M Bodenmiller, Aaron D Showalter

Muscle Nerve· May 2006

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Conserved amino acid sequences confer nuclear localization upon the Prophet of Pit-1 pituitary transcription factor protein.
J Chico Guy, Chad S Hunter, Aaron D Showalter, Timothy P L Smith, Kanokwan Charoonpatrapong

Gene· July 2004

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Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors.
Kyle W Sloop, Julia Xiao-Chun Cao, Angela M Siesky, Hong Yan Zhang, Diane M Bodenmiller, Aaron D Showalter

J Clin Invest· June 2004

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Cloning and analysis of axolotl ISL2 and LHX2 LIM-homeodomain transcription factors.
Aaron D Showalter, Benjamin C Yaden, Ellen A G Chernoff, Simon J Rhodes

Genesis· March 2004

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Genetic defects in the development and function of the anterior pituitary gland.
Lisa J Cushman, Aaron D Showalter, Simon J Rhodes

Ann Med· January 2003

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Differential conservation of transcriptional domains of mammalian Prophet of Pit-1 proteins revealed by structural studies of the bovine gene and comparative functional analysis of the protein.
Aaron D Showalter, Timothy P L Smith, Gary L Bennett, Kyle W Sloop, Julie A Whitsett

Gene· May 2002

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