Publications by authors named "Timothy A Shepherd"

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At the Intersection of Industry, Academia, and Government: How Do We Facilitate Productive Precision Livestock Farming in Practice?
Brett C Ramirez, Hongwei Xin, Patrick G Halbur, Donald H Beermann, Stephanie L Hansen, Timothy A Shepherd

Animals (Basel)· August 2019

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Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models.
Harold B Brooks, Timothy I Meier, Sandaruwan Geeganage, Kevin R Fales, Kenneth J Thrasher, Timothy A Shepherd

Sci Rep· October 2018

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Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
Kevin R Fales, F George Njoroge, Harold B Brooks, Stefan Thibodeaux, Alicia Torrado, Timothy A Shepherd

J Med Chem· December 2017

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Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety.
Timothy I Richardson, Scott A Frank, Minmin Wang, Christian A Clarke, Scott A Jones, Timothy A Shepherd

Bioorg Med Chem Lett· July 2007

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Progress toward the discovery and development of efficacious BACE inhibitors.
Timothy B Durham, Timothy A Shepherd

Curr Opin Drug Discov Devel· November 2006

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A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats.
Conrad W Hummel, Andrew G Geiser, Henry U Bryant, Ilene R Cohen, Robert D Dally, Timothy A Shepherd

J Med Chem· November 2005

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A new selective estrogen receptor modulator with potent uterine antagonist activity, agonist activity in bone, and minimal ovarian stimulation.
Andrew G Geiser, Conrad W Hummel, Michael W Draper, Judith W Henck, Ilene R Cohen, Timothy A Shepherd

Endocrinology· October 2005

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Design and synthesis of a novel series of 1,2-disubstituted cyclopentanes as small, potent potentiators of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA) receptors.
Timothy A Shepherd, James A Aikins, David Bleakman, Buddy E Cantrell, John P Rearick

J Med Chem· May 2002

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