Publications by authors named "Daekyu Sun"

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Role of Human DNA Ligases in Mediating Pharmacological Activities of Flavonoids.
Daekyu Sun, Vijay Gokhale

Int J Mol Sci· February 2025

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Adefovir Dipivoxil as a Therapeutic Candidate for Medullary Thyroid Carcinoma: Targeting RET and STAT3 Proto-Oncogenes.
Tariq Alqahtani, Vishnu Kumarasamy, Sahar Saleh Alghamdi, Rasha Saad Suliman, Khalid Bin Saleh, Daekyu Sun

Cancers (Basel)· April 2023

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Selective Antitumor Activity of Datelliptium toward Medullary Thyroid Carcinoma by Downregulating RET Transcriptional Activity.
Tariq Alqahtani, Abdullah Alswied, Daekyu Sun

Cancers (Basel)· June 2021

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Electrophoretic Mobility Shift Assay and Dimethyl Sulfate Footprinting for Characterization of G-Quadruplexes and G-Quadruplex-Protein Complexes.
Buket Onel, Guanhui Wu, Daekyu Sun, Clement Lin, Danzhou Yang

Methods Mol Biol· April 2020

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Chromatin Immunoprecipitation Assay to Analyze the Effect of G-Quadruplex Interactive Agents on the Binding of RNA Polymerase II and Transcription Factors to a Target Promoter Region.
Daekyu Sun

Methods Mol Biol· April 2020

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Salinomycin and its derivatives as potent RET transcriptional inhibitors for the treatment of medullary thyroid carcinoma.
Tariq Alqahtani, Vishnu Muthuraj Kumarasamy, Adam Huczyński, Daekyu Sun

Int J Oncol· January 2020

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Synthesis of Constrained Heterocycles Employing Two Post-Ugi Cyclization Methods for Rapid Library Generation with In Cellulo Activity.
Nicholas McConnell, Zhigang Xu, Vishnu Kumarasamy, Daekyu Sun, Brendan Frett

ChemistrySelect· December 2017

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Demonstration of a potent RET transcriptional inhibitor for the treatment of medullary thyroid carcinoma based on an ellipticine derivative.
Vishnu Muthuraj Kumarasamy, Daekyu Sun

Int J Oncol· July 2017

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Selective repression of RET proto-oncogene in medullary thyroid carcinoma by a natural alkaloid berberine.
Vishnu Muthuraj Kumarasamy, Yoon-Joo Shin, John White, Daekyu Sun

BMC Cancer· August 2015

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Synthesis and characterization of a small analogue of the anticancer natural product leinamycin.
Kripa Keerthi, Anuruddha Rajapakse, Daekyu Sun, Kent S Gates

Bioorg Med Chem· January 2013

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DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.
Velliyur Viswesh, Allison M Hays, Kent Gates, Daekyu Sun

Bioorg Med Chem· July 2012

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The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product.
Santhosh Sivaramakrishnan, Leonid Breydo, Daekyu Sun, Kent S Gates

Bioorg Med Chem Lett· June 2012

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Heterogeneous nuclear ribonucleoprotein K and nucleolin as transcriptional activators of the vascular endothelial growth factor promoter through interaction with secondary DNA structures.
Diana J Uribe, Kexiao Guo, Yoon-Joo Shin, Daekyu Sun

Biochemistry· May 2011

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Evidence of the formation of G-quadruplex structures in the promoter region of the human vascular endothelial growth factor gene.
Daekyu Sun, Kexiao Guo, Yoon-Joo Shin

Nucleic Acids Res· March 2011

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Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent.
Jiahui Zheng, Xiaoqian Liu, Qing Yuan, Yoon-Joo Shin, Daekyu Sun

Org Biomol Chem· March 2010

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In vitro footprinting of promoter regions within supercoiled plasmid DNA.
Daekyu Sun

Methods Mol Biol· February 2010

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Biochemical techniques for the characterization of G-quadruplex structures: EMSA, DMS footprinting, and DNA polymerase stop assay.
Daekyu Sun, Laurence H Hurley

Methods Mol Biol· February 2010

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Synthesis and antiproliferating activity of iron chelators of hydroxyamino-1,3,5-triazine family.
Daekyu Sun, Galina Melman, Nickolas J Letourneau, Allison M Hays, Artem Melman

Bioorg Med Chem Lett· January 2010

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Characterization of DNA damage induced by a natural product antitumor antibiotic leinamycin in human cancer cells.
Velliyur Viswesh, Kent Gates, Daekyu Sun

Chem Res Toxicol· January 2010

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Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein.
Verónica González, Kexiao Guo, Laurence Hurley, Daekyu Sun

J Biol Chem· August 2009

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The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression.
Daekyu Sun, Laurence H Hurley

J Med Chem· May 2009

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NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1).
Thomas S Dexheimer, Steven S Carey, Song Zuohe, Vijay M Gokhale, Xiaohui Hu, Daekyu Sun

Mol Cancer Ther· May 2009

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Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene.
Kexiao Guo, Vijay Gokhale, Laurence H Hurley, Daekyu Sun

Nucleic Acids Res· August 2008

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The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents.
Daekyu Sun, Wei-Jun Liu, Kexiao Guo, Jadrian J Rusche, Scot Ebbinghaus

Mol Cancer Ther· April 2008

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Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4.
Yong Qin, Evonne M Rezler, Vijay Gokhale, Daekyu Sun, Laurence H Hurley

Nucleic Acids Res· January 2008

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