Publications by authors named "Daniel Flaherty"

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Bacterial Carbonic Anhydrase Inhibitor CAI0019 Demonstrates Efficacy in Septicemic Peritonitis Mouse Model While Sparing the Microbiome.
Nader S Abutaleb, Katrina J Holly, Carolyn K Metcalfe, Ahmed A Abouelkhair, Prabhakara R Tharra, Daniel P Flaherty

ACS Infect Dis· December 2025

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Hit-to-Lead Optimization of Acetazolamide-Based Bacterial Carbonic Anhydrase Inhibitors with Efficacy In Vivo for Treatment of Vancomycin-Resistant Enterococci Septicemia.
Katrina J Holly, Prabhakara R Tharra, Nader S Abutaleb, Alessio Nocentini, Ahmed A Abouelkhair, Daniel P Flaherty

J Med Chem· September 2025

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A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation.
Bao V Nguyen, Can Özden, Kairong Dong, Oguz Can Koc, Ana P Torres-Ocampo, Daniel Flaherty

Nat Commun· September 2025

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Redesigning oxazolidinones as carbonic anhydrase inhibitors against vancomycin-resistant enterococci.
Andrea Ammara, Simone Giovannuzzi, Alessandro Bonardi, Nader S Abutaleb, Ahmed A Abouelkhair, Daniel P Flaherty

Eur J Med Chem· July 2025

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A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation.
Bao V Nguyen, Can Özden, Kairong Dong, Oguz Can Koc, Ana P Torres-Ocampo, Daniel Flaherty

bioRxiv· May 2025

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First reported case of a spontaneous and healthy pregnancy in a woman with persistent CAR T-cells 5 years after treatment for diffuse large B-cell lymphoma.
Ethan Abraham Canty, Lori Broderick, Daniel Flaherty, Marin Xavier, Sunita D Nasta

J Immunother Cancer· April 2025

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Biochemical pharmacology of adenylyl cyclases in cancer.
Bikash Chandra Jena, Daniel P Flaherty, Valerie P O'Brien, Val J Watts

Biochem Pharmacol· October 2024

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Pyrazolo-Pyrimidinones with Improved Solubility and Selective Inhibition of Adenylyl Cyclase Type 1 Activity for Treatment of Inflammatory Pain.
Annadka Shrinidhi, Tiffany S Dwyer, Jason A Scott, Val J Watts, Daniel P Flaherty

J Med Chem· October 2024

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Optimization of Ethoxzolamide Analogs with Improved Pharmacokinetic Properties for Efficacy against .
Molly S Youse, Nader S Abutaleb, Alessio Nocentini, Abdallah S Abdelsattar, Farman Ali, Daniel P Flaherty

J Med Chem· September 2024

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Neisseria gonorrhoeae carbonic anhydrase inhibition.
Molly S Youse, Katrina J Holly, Daniel P Flaherty

Enzymes· September 2024

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Enterococci carbonic anhydrase inhibition.
Katrina J Holly, Molly S Youse, Daniel P Flaherty

Enzymes· September 2024

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Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension.
Haiyang Tang, Akash Gupta, Seth A Morrisroe, Changlei Bao, Tae-Hwi Schwantes-An, Daniel P Flaherty

Circulation· July 2024

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Discovery and validation of a novel inhibitor of HYPE-mediated AMPylation.
Ali Camara, Heerak Chugh, Alyssa George, Lukas Dolidze, Kevin Ryu, Daniel P Flaherty

Cell Stress Chaperones· June 2024

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Development of Penicillin-Based Carbonic Anhydrase Inhibitors Targeting Multidrug-Resistant .
Alessandro Bonardi, Alessio Nocentini, Simone Giovannuzzi, Niccolò Paoletti, Andrea Ammara, Daniel P Flaherty

J Med Chem· June 2024

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Unguarded liabilities: complex amino acid dependence exposes unique avenues of inhibition.
Katrina J Holly, Arti Kataria, Daniel P Flaherty, Ashley M Groshong

Front Antibiot· May 2024

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Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1.
Ryan D Imhoff, Rishi Patel, Muhammad Hassan Safdar, Hannah B L Jones, Adan Pinto-Fernandez, Daniel P Flaherty

J Med Chem· March 2024

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Altered Protein Dynamics and a More Reactive Catalytic Cysteine in a Neurodegeneration-associated UCHL1 Mutant.
Sebastian Kenny, Chih-Hsuan Lai, Tsung-Sheng Chiang, Kwame Brown, Chad S Hewitt, Daniel P Flaherty

J Mol Biol· February 2024

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Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates.
Simone Giovannuzzi, Anil Kumar Marapaka, Nader S Abutaleb, Fabrizio Carta, Hsin-Wen Liang, Daniel P Flaherty

J Enzyme Inhib Med Chem· December 2023

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Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate.
Amanda L Graboski, Mark E Kowalewski, Joshua B Simpson, Xufeng Cao, Mary Ha, Daniel P Flaherty

Cell Chem Biol· November 2023

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Identification of covalent fragment inhibitors for Plasmodium falciparum UCHL3 with anti-malarial efficacy.
Ryan D Imhoff, Melissa R Rosenthal, Kutub Ashraf, Purnima Bhanot, Caroline L Ng, Daniel P Flaherty

Bioorg Med Chem Lett· October 2023

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Carbonic Anhydrase Inhibition as a Target for Antibiotic Synergy in Enterococci.
Gayatri Shankar Chilambi, Yu-Hao Wang, Nathan R Wallace, Chetachukwu Obiwuma, Kirsten M Evans, Daniel P Flaherty

Microbiol Spectr· August 2023

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Genetic Determinants of Serum-Associated Adaptive Efflux-Mediated Antibiotic Resistance.
Mikaeel Young, Michaelle Chojnacki, Catlyn Blanchard, Xufeng Cao, William L Johnson, Daniel Flaherty

Antibiotics (Basel)· July 2023

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Evaluation of 1,3,4-Thiadiazole Carbonic Anhydrase Inhibitors for Gut Decolonization of Vancomycin-Resistant Enterococci.
Nader S Abutaleb, Annadka Shrinidhi, Aloka B Bandara, Mohamed N Seleem, Daniel P Flaherty

ACS Med Chem Lett· April 2023

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Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to α-Carbonic Anhydrase.
Anil Kumar Marapaka, Alessio Nocentini, Molly S Youse, Weiwei An, Katrina J Holly, Daniel P Flaherty

ACS Med Chem Lett· January 2023

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Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype.
Tiffany S Dwyer, Joseph B O'Brien, Christopher P Ptak, Justin E LaVigne, Daniel P Flaherty

Front Pharmacol· September 2022

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