Publications by authors named "Daniel Mayhugh"

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Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
Mark D Chappell, Renhua Li, Stephon C Smith, Bruce A Dressman, Eric G Tromiczak, Daniel Mayhugh

J Med Chem· December 2016

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Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8.
Kevin M Gardinier, Douglas L Gernert, Warren J Porter, Jon K Reel, Paul L Ornstein, Daniel Mayhugh

J Med Chem· May 2016

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Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors.
Ana Escribano, Ana I Mateo, Eva M Martin de la Nava, Daniel R Mayhugh, Sandra L Cockerham

Bioorg Med Chem Lett· June 2012

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N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes.
Matthew J Fell, Jeffrey M Witkin, Julie F Falcone, Jason S Katner, Kenneth W Perry, Daniel Mayhugh

J Pharmacol Exp Ther· January 2011

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Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist.
Yanping Xu, Daniel Mayhugh, Ashraf Saeed, Xiaodong Wang, Richard C Thompson

J Med Chem· November 2003

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