Publications by authors named "Danielle Needle"

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Inositol Phosphate Kinase Architecture: Practical Approaches and Lessons Learned.
Danielle Needle, Katarina Bauer, Richard R Mattocks, Gregory J Miller

Methods Mol Biol· August 2025

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Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification.
Xue Zhi Zhao, Wenjie Wang, George T Lountos, Evgeny Kiselev, Joseph E Tropea, Danielle Needle

RSC Chem Biol· May 2023

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Self-inhibited State of Venezuelan Equine Encephalitis Virus (VEEV) nsP2 Cysteine Protease: A Crystallographic and Molecular Dynamics Analysis.
Gyula Hoffka, George T Lountos, Danielle Needle, Alexander Wlodawer, David S Waugh

J Mol Biol· March 2023

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Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1.
Xue Zhi Zhao, Wenjie Wang, George T Lountos, Joseph E Tropea, Danielle Needle

Front Chem· August 2022

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Characterization of a broadly specific cadaverine N-hydroxylase involved in desferrioxamine B biosynthesis in Streptomyces sviceus.
Lesley-Ann Giddings, George T Lountos, Kang Woo Kim, Matthew Brockley, Danielle Needle

PLoS One· October 2021

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Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites.
Xue Zhi Zhao, Evgeny Kiselev, George T Lountos, Wenjie Wang, Joseph E Tropea, Danielle Needle

Chem Sci· January 2021

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Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening.
George T Lountos, Xue Zhi Zhao, Evgeny Kiselev, Joseph E Tropea, Danielle Needle

Nucleic Acids Res· November 2019

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The molecular mechanism of dsRNA processing by a bacterial Dicer.
Lan Jin, He Song, Joseph E Tropea, Danielle Needle, David S Waugh

Nucleic Acids Res· May 2019

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A Small-Molecule Microarray Approach for the Identification of E2 Enzyme Inhibitors in Ubiquitin-Like Conjugation Pathways.
Katherine Zlotkowski, William M Hewitt, Ranu S Sinniah, Joseph E Tropea, Danielle Needle

SLAS Discov· July 2017

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Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9.
William M Hewitt, George T Lountos, Katherine Zlotkowski, Samuel D Dahlhauser, Lindsey B Saunders, Danielle Needle

Angew Chem Int Ed Engl· May 2016

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Structures of the Middle East respiratory syndrome coronavirus 3C-like protease reveal insights into substrate specificity.
Danielle Needle, George T Lountos, David S Waugh

Acta Crystallogr D Biol Crystallogr· May 2015

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Rescuing aggregation-prone proteins in Escherichia coli with a dual His₆-MBP tag.
Danielle Needle, David S Waugh

Methods Mol Biol· February 2015

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Structural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis.
Gary X Shaw, Yue Li, Genbin Shi, Yan Wu, Scott Cherry, Danielle Needle

FEBS J· September 2014

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Affibody-DyLight conjugates for in vivo assessment of HER2 expression by near-infrared optical imaging.
Rafal Zielinski, Moinuddin Hassan, Ilya Lyakhov, Danielle Needle, Victor Chernomordik

PLoS One· April 2013

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Hyperthermia-triggered intracellular delivery of anticancer agent to HER2(+) cells by HER2-specific affibody (ZHER2-GS-Cys)-conjugated thermosensitive liposomes (HER2(+) affisomes).
Brandon Smith, Ilya Lyakhov, Kristin Loomis, Danielle Needle, Ulrich Baxa

J Control Release· July 2011

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Sequence of the Escherichia coli O121 O-antigen gene cluster and detection of enterohemorrhagic E. coli O121 by PCR amplification of the wzx and wzy genes.
Pina M Fratamico, Connie E Briggs, Danielle Needle, Chin-Yi Chen, Chitrita DebRoy

J Clin Microbiol· July 2003

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