Publications by authors named "Genbin Shi"

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Bisubstrate inhibitors of 6-hydroxymethyl-7,8-dihydroptein pyrophosphokinase: Toward cell permeability.
Genbin Shi, Gary X Shaw, Xinhua Ji

Bioorg Med Chem Lett· November 2024

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Inhibition of HIV-1 release by ADAM metalloproteinase inhibitors.
Joanna Ireland, Jason Segura, Genbin Shi, Julianna Buchwald, Gwynne Roth

Front Microbiol· March 2024

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Crystal structure of Escherichia coli thiamine pyrophosphate-sensing riboswitch in the apo state.
Hyun Kyung Lee, Yun-Tzai Lee, Lixin Fan, Haley M Wilt, Chelsie E Conrad, Genbin Shi

Structure· July 2023

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Structure of dihydroneopterin aldolase suggests a fragment-based strategy for isozyme-specific inhibitor design.
Gary X Shaw, Lixin Fan, Scott Cherry, Genbin Shi, Joseph E Tropea

Curr Res Struct Biol· January 2023

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Bisubstrate inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: Transition state analogs for high affinity binding.
Genbin Shi, Gary X Shaw, Fengxia Zhu, Sergey G Tarasov, Xinhua Ji

Bioorg Med Chem· January 2021

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Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases.
Jacynthe L Toulouse, Genbin Shi, Claudèle Lemay-St-Denis, Maximilian C C J C Ebert, Daniel Deon

ACS Med Chem Lett· November 2020

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Overproduction of a Dominant Mutant of the Conserved Era GTPase Inhibits Cell Division in Escherichia coli.
Xiaomei Zhou, Howard K Peters, Xintian Li, Nina Costantino, Vandana Kumari, Genbin Shi

J Bacteriol· October 2020

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Design, synthesis, and anticancer activity evaluation of irreversible allosteric inhibitors of the ubiquitin-conjugating enzyme Ube2g2.
Chao Wang, Genbin Shi, Xinhua Ji

Medchemcomm· November 2018

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Cyclic depsipeptides as potential cancer therapeutics.
Jirouta Kitagaki, Genbin Shi, Shizuka Miyauchi, Shinya Murakami, Yili Yang

Anticancer Drugs· March 2015

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Structural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis.
Gary X Shaw, Yue Li, Genbin Shi, Yan Wu, Scott Cherry

FEBS J· September 2014

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Bisubstrate analog inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: new lead exhibits a distinct binding mode.
Genbin Shi, Gary Shaw, Yue Li, Yan Wu, Honggao Yan

Bioorg Med Chem· July 2012

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Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved properties.
Genbin Shi, Gary Shaw, Yu-He Liang, Priadarsini Subburaman, Yue Li

Bioorg Med Chem· January 2012

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New ways to derivatize at position 6 of 7,7-dimethyl-7,8-dihydropterin.
Genbin Shi, Xinhua Ji

Tetrahedron Lett· November 2011

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CITED1 expression in Wilms' tumor and embryonic kidney.
Harold N Lovvorn, Jenifer Westrup, Shaun Opperman, Scott Boyle, Genbin Shi

Neoplasia· July 2007

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Wilms' tumorigenesis is altered by misexpression of the transcriptional co-activator, CITED1.
Harold N Lovvorn, Scott Boyle, Genbin Shi, Yu Shyr, Marcia L Wills

J Pediatr Surg· March 2007

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Mechanism of the conformational transitions in 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase as revealed by NMR spectroscopy.
Guangyu Li, Krzysztof Felczak, Genbin Shi, Honggao Yan

Biochemistry· October 2006

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The transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner.
Genbin Shi, Scott C Boyle, Duncan B Sparrow, Sally L Dunwoodie, Toshi Shioda

J Biol Chem· September 2006

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Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning.
Sergey Plisov, Michael Tsang, Genbin Shi, Scott Boyle, Kiyoshi Yoshino, Toshi Shioda

J Am Soc Nephrol· June 2005

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Is the critical role of loop 3 of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase in catalysis due to loop-3 residues arginine-84 and tryptophan-89? Site-directed mutagenesis, biochemical, and crystallographic studies.
Yue Li, Jaroslaw Blaszczyk, Yan Wu, Genbin Shi, Xinhua Ji

Biochemistry· June 2005

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Structural basis of heteromeric smad protein assembly in TGF-beta signaling.
Benoy M Chacko, Bin Y Qin, Ashutosh Tiwari, Genbin Shi, Suvana Lam

Mol Cell· September 2004

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Reaction trajectory of pyrophosphoryl transfer catalyzed by 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Jaroslaw Blaszczyk, Genbin Shi, Yue Li, Honggao Yan, Xinhua Ji

Structure· March 2004

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Essential roles of a dynamic loop in the catalysis of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Jaroslaw Blaszczyk, Yue Li, Yan Wu, Genbin Shi, Xinhua Ji

Biochemistry· February 2004

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Conformation-dependent intermolecular interaction energies of the triphosphate anion with divalent metal cations. Application to the ATP-binding site of a binuclear bacterial enzyme. A parallel quantum chemical and polarizable molecular mechanics investigation.
Nohad Gresh, Gen-Bin Shi

J Comput Chem· January 2004

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Dynamic roles of arginine residues 82 and 92 of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: crystallographic studies.
Jaroslaw Blaszczyk, Yue Li, Genbin Shi, Honggao Yan, Xinhua Ji

Biochemistry· February 2003

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Chemical transformation is not rate-limiting in the reaction catalyzed by Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Yue Li, Yunchen Gong, Genbin Shi, Jaroslaw Blaszczyk, Xinhua Ji

Biochemistry· July 2002

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