Publications by authors named "Darren Cook"

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Improving police recorded crime data for domestic violence and abuse through natural language processing.
Darren Cook, Ruth Weir, Leslie Humphreys

Front Sociol· December 2025

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Musculoskeletal physiotherapists' experiences of using remote consultations during the COVID-19 pandemic: A qualitative study.
Darren Cook, Jennifer Pearson

Musculoskelet Sci Pract· August 2024

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A text-based conversational agent for asthma support: Mixed-methods feasibility study.
Darren Cook, Dorian Peters, Laura Moradbakhti, Ting Su, Marco Da Re

Digit Health· June 2024

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Assessing the Feasibility of a Text-Based Conversational Agent for Asthma Support: Protocol for a Mixed Methods Observational Study.
Rafael A Calvo, Dorian Peters, Laura Moradbakhti, Darren Cook, Georgios Rizos

JMIR Res Protoc· February 2023

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depletion blocks transmission of lymphatic filariasis by preventing chitinase-dependent parasite exsheathment.
Shannon Quek, Darren A N Cook, Yang Wu, Amy E Marriott, Andrew Steven

Proc Natl Acad Sci U S A· April 2022

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X-treme loss of sequence diversity linked to neo-X chromosomes in filarial nematodes.
John Mattick, Silvia Libro, Robin Bromley, Wanpen Chaicumpa, Matthew Chung, Darren Cook

PLoS Negl Trop Dis· October 2021

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Development of Pyrazolopyrimidine Anti- Agents for the Treatment of Filariasis.
Paul McGillan, Neil G Berry, Gemma L Nixon, Suet C Leung, Peter J H Webborn, Darren A Cook

ACS Med Chem Lett· September 2021

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Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination.
James R Marshall, Peiyuan Yao, Sarah L Montgomery, James D Finnigan, Thomas W Thorpe, Darren J Cook

Nat Chem· February 2021

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Cytochromes P450 (P450s): A review of the class system with a focus on prokaryotic P450s.
James D Finnigan, Carl Young, Darren J Cook, Simon J Charnock, Gary W Black

Adv Protein Chem Struct Biol· January 2021

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Laboratory evaluation of molecular xenomonitoring using mosquito and tsetse fly excreta/feces to amplify , , and DNA.
Nils Pilotte, Darren A N Cook, Joseph Pryce, Michael F Zulch, Corrado Minetti

Gates Open Res· June 2020

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Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.
Robert T Jacobs, Christopher S Lunde, Yvonne R Freund, Vincent Hernandez, Xianfeng Li, Darren A N Cook

J Med Chem· March 2019

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Preclinical development of an oral anti- macrolide drug for the treatment of lymphatic filariasis and onchocerciasis.
Mark J Taylor, Thomas W von Geldern, Louise Ford, Marc P Hübner, Kennan Marsh, Darren A N Cook

Sci Transl Med· March 2019

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Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides.
Rachel H Clare, Catherine Bardelle, Paul Harper, W David Hong, Ulf Börjesson, Darren A N Cook

Nat Commun· January 2019

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AWZ1066S, a highly specific anti- drug candidate for a short-course treatment of filariasis.
W David Hong, Farid Benayoud, Gemma L Nixon, Louise Ford, Kelly L Johnston, Darren A N Cook

Proc Natl Acad Sci U S A· January 2019

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A superhydrophobic cone to facilitate the xenomonitoring of filarial parasites, malaria, and trypanosomes using mosquito excreta/feces.
Darren A N Cook, Nils Pilotte, Corrado Minetti, Steven A Williams, Lisa J Reimer

Gates Open Res· April 2018

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Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia.
Joseph D Turner, Nicolas Pionnier, Julio Furlong-Silva, Hanna Sjoberg, Stephen Cross, Darren A N Cook

PLoS Pathog· March 2018

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Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis.
Raman Sharma, Ghaith Aljayyoussi, Hayley E Tyrer, Joanne Gamble, Laura Hayward, Darren A N Cook

Sci Rep· January 2018

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Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.
Ghaith Aljayyoussi, Hayley E Tyrer, Louise Ford, Hanna Sjoberg, Nicolas Pionnier, Darren A N Cook

Sci Rep· January 2018

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Albendazole and antibiotics synergize to deliver short-course anti- curative treatments in preclinical models of filariasis.
Joseph D Turner, Raman Sharma, Ghaith Al Jayoussi, Hayley E Tyrer, Joanne Gamble, Darren A N Cook

Proc Natl Acad Sci U S A· November 2017

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Identification and prioritization of novel anti- chemotypes from screening a 10,000-compound diversity library.
Kelly L Johnston, Darren A N Cook, Neil G Berry, W David Hong, Rachel H Clare

Sci Adv· September 2017

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Brugia malayi microfilariae adhere to human vascular endothelial cells in a C3-dependent manner.
Jan-Hendrik Schroeder, David McCarthy, Tadge Szestak, Darren A Cook, Mark J Taylor

PLoS Negl Trop Dis· May 2017

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Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.
Ghaith Aljayyoussi, Hayley E Tyrer, Louise Ford, Hanna Sjoberg, Nicolas Pionnier, Darren A N Cook

Sci Rep· March 2017

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Filarial infection influences mosquito behaviour and fecundity.
Katherine Gleave, Darren Cook, Mark J Taylor, Lisa J Reimer

Sci Rep· October 2016

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Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis.
Raman Sharma, Ghaith Al Jayoussi, Hayley E Tyrer, Joanne Gamble, Laura Hayward, Darren A N Cook

Sci Rep· March 2016

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A murine macrofilaricide pre-clinical screening model for onchocerciasis and lymphatic filariasis.
Alice Halliday, Ana F Guimaraes, Hayley E Tyrer, Haelly Mejane Metuge, Chounna Ndongmo Winston Patrick, Darren Cook

Parasit Vectors· October 2014

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