Publications by authors named "Darren Griffith"

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Novel Platinum(II) Tetrazine Complex Capable of Live-Cell IEDDA Reaction.
Paul D O'Dowd, Dan Wu, Alby Benny, Ellen King, Alice Harford, Darren M Griffith

Chembiochem· September 2025

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Quantitative proteomic analysis reveals Ga(III) polypyridyl catecholate complexes disrupt Aspergillus fumigatus mitochondrial function.
Magdalena Piatek, Brunella Grassiri, Lewis More O'Ferrall, Anna Maria Piras, Giovanna Batoni, Darren Griffith

J Biol Inorg Chem· December 2024

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Correction: Quantitative proteomic analysis reveals Ga(III) polypyridyl catecholate complexes disrupt Aspergillus fumigatus mitochondrial function.
Magdalena Piatek, Brunella Grassiri, Lewis More O'Ferrall, Anna Maria Piras, Giovanna Batoni, Darren Griffith

J Biol Inorg Chem· December 2024

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The activity of a Ga(III) catecholate complex against Aspergillus fumigatus in conditions mimicking cystic fibrosis lung and inhaled formulations for its pulmonary administration.
Brunella Grassiri, Semih Esin, Magdalena E Piatek, Lewis More O'Ferrall, Johannes A Sake, Darren M Griffith

Int J Pharm· December 2024

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Click-Capable Phenanthriplatin Derivatives as Tools to Study Pt(II)-Induced Nucleolar Stress.
Paul D O'Dowd, Andres S Guerrero, Katelyn R Alley, Hannah C Pigg, Fiona O'Neill, Darren M Griffith

ACS Chem Biol· April 2024

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First-in-class metallo-PROTAC as an effective degrader of select Pt-binding proteins.
Paul D O'Dowd, Graeme P Sullivan, Daniel A Rodrigues, Tríona Ní Chonghaile, Darren M Griffith

Chem Commun (Camb)· October 2023

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Comparison of click-capable oxaliplatin and cisplatin derivatives to better understand Pt(ii)-induced nucleolar stress.
Andres S Guerrero, Paul D O'Dowd, Hannah C Pigg, Katelyn R Alley, Darren M Griffith

RSC Chem Biol· October 2023

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Synthesis, characterisation and antibacterial activity of novel Ga(III) polypyridyl catecholate complexes.
Lewis More O'Ferrall, Magdalena Piatek, Brendan Twamley, Kevin Kavanagh, Christine O'Connor, Darren M Griffith

Dalton Trans· August 2023

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A -Pt(II) hedgehog pathway inhibitor complex with cytotoxicity towards breast cancer stem cells and triple negative breast cancer cells.
Aisling L Ryan, Joshua Northcote-Smith, Aoife McKeon, Andrew Roe, Paul O'Dowd, Darren M Griffith

Dalton Trans· December 2022

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Advances in the Design and Development of PROTAC-mediated HDAC Degradation.
Daniel Alencar Rodrigues, Andrew Roe, Darren Griffith, Tríona Ní Chonghaile

Curr Top Med Chem· March 2022

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Medicinal chemistry and biomedical applications of bismuth-based compounds and nanoparticles.
Darren M Griffith, Hongyan Li, Melissa V Werrett, Philip C Andrews, Hongzhe Sun

Chem Soc Rev· November 2021

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A single microbubble formulation carrying 5-fluorouridine, Irinotecan and oxaliplatin to enable FOLFIRINOX treatment of pancreatic and colon cancer using ultrasound targeted microbubble destruction.
Jinhui Gao, Keiran A Logan, Heather Nesbitt, Bridgeen Callan, Thomas McKaig, Darren M Griffith

J Control Release· October 2021

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Quantitative proteomic reveals gallium maltolate induces an iron-limited stress response and reduced quorum-sensing in Pseudomonas aeruginosa.
Magdalena Piatek, Darren M Griffith, Kevin Kavanagh

J Biol Inorg Chem· December 2020

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Synthesis and characterisation of Co(iii) complexes of N-formyl hydroxylamines and antibacterial activity of a Co(iii) peptide deformylase inhibitor complex.
Máté Kozsup, Donal M Keogan, Deirdre Fitzgerald-Hughes, Éva A Enyedy, Brendan Twamley, Darren M Griffith

Dalton Trans· June 2020

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Exploiting azide-alkyne click chemistry in the synthesis, tracking and targeting of platinum anticancer complexes.
Nicola J Farrer, Darren M Griffith

Curr Opin Chem Biol· April 2020

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Ni(II), Pd(II), and Pt(II) Complexes of the Hedgehog Pathway Inhibitor GANT61-D.
Aisling L Ryan, Marie-Claire Fitzgerald, András Ozsváth, Brendan Twamley, Péter Buglyó, Darren M Griffith

Inorg Chem· December 2019

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Au(III) and Pt(II) Complexes of a Novel and Versatile 1,4-Disubstituted 1,2,3-Triazole-Based Ligand Possessing Diverse Secondary and Tertiary Coordinating Groups.
Eolann Kitteringham, Zehao Zhou, Brendan Twamley, Darren M Griffith

Inorg Chem· October 2018

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Development of a novel carboplatin like cytoplasmic trackable near infrared fluorophore conjugate via strain-promoted azide alkyne cycloaddition.
Eolann Kitteringham, Dan Wu, Shane Cheung, Brendan Twamley, Donal F O'Shea, Darren M Griffith

J Inorg Biochem· May 2018

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Correction: Griffith, D.M., et al. Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-μ. In Vitro Synergy Quantification of Pifithrin-μ Combined with Pt Drugs in Prostate and Colorectal Cancer Cells. Molecules 2016, 21, 949.
Aoife M McKeon, Alan Egan, Jay Chandanshive, Helena McMahon, Darren M Griffith

Molecules· November 2016

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Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-μ. In Vitro Synergy Quantification of Pifithrin-μ Combined with Pt Drugs in Prostate and Colorectal Cancer Cells.
Aoife M McKeon, Alan Egan, Jay Chandanshive, Helena McMahon, Darren M Griffith

Molecules· July 2016

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Current and potential applications of bismuth-based drugs.
Donal M Keogan, Darren M Griffith

Molecules· September 2014

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A novel platinum complex of the histone deacetylase inhibitor belinostat: rational design, development and in vitro cytotoxicity.
James P Parker, Hassan Nimir, Darren M Griffith, Brian Duff, Anthony J Chubb

J Inorg Biochem· July 2013

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The prevalence of metal-based drugs as therapeutic or diagnostic agents: beyond platinum.
Declan Gaynor, Darren M Griffith

Dalton Trans· November 2012

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Valuable insight into the anticancer activity of the platinum-histone deacetylase inhibitor conjugate, cis-[Pt(NH3)2malSAHA-2H)].
Viktor Brabec, Darren M Griffith, Anna Kisova, Hana Kostrhunova, Lenka Zerzankova

Mol Pharm· July 2012

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Novel trans-platinum complexes of the histone deacetylase inhibitor valproic acid; synthesis, in vitro cytotoxicity and mutagenicity.
Darren M Griffith, Brian Duff, Kyrill Y Suponitsky, Kevin Kavanagh, Maria P Morgan

J Inorg Biochem· June 2011

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