Publications by authors named "Daniel A Rodrigues"

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Design, synthesis and pharmacological evaluation of multitarget GPR40 agonists/HDAC6 inhibitors for Alzheimer's disease.
Pedro de Sena M Pinheiro, Francesca de Chirico, Manuela Loi, Stefania Trazzi, Elisabetta Ciani, Daniel Alencar Rodrigues

Eur J Med Chem· October 2025

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Drug Repurposing by Virtual Screening: Identification of New Already Approved ROCK Inhibitors as Promising Drugs to Target Neurodegeneration.
Lucas Silva Franco, Daniel Alencar Rodrigues, Gabriela Joras Baumart, Bárbara da Silva Mascarenhas de Jesus, Flávia Carvalho Alcantara Gomes

ACS Omega· July 2025

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Exploring the Conformational Effects of - and -Methylation of -Acylhydrazones.
Lucas Silva Franco, Marina Amaral Alves, Carlos Mauricio R Sant'Anna, Isadora Tairinne de Sena Bastos, Regina Cely Rodrigues Barroso, Daniel A Rodrigues

ACS Omega· May 2025

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Drug Discovery for Histone Deacetylase Inhibition: Past, Present and Future of Zinc-Binding Groups.
Gustavo Salgado Pires, Heber Victor Tolomeu, Daniel Alencar Rodrigues, Lídia Moreira Lima, Carlos Alberto Manssour Fraga

Pharmaceuticals (Basel)· April 2025

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Selective inhibition of HDAC6 by N-acylhydrazone derivative reduces the proliferation and induces senescence in carcinoma hepatocellular cells.
Guilherme Álvaro Ferreira-Silva, Daniel Alencar Rodrigues, Carolina Girotto Pressete, Ester Siqueira Caixeta, Angel Mauricio Castro Gamero

Toxicol In Vitro· August 2024

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Click-Capable Phenanthriplatin Derivatives as Tools to Study Pt(II)-Induced Nucleolar Stress.
Paul D O'Dowd, Andres S Guerrero, Katelyn R Alley, Hannah C Pigg, Fiona O'Neill, Daniel A Rodrigues

ACS Chem Biol· April 2024

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First-in-class metallo-PROTAC as an effective degrader of select Pt-binding proteins.
Paul D O'Dowd, Graeme P Sullivan, Daniel A Rodrigues, Tríona Ní Chonghaile, Darren M Griffith

Chem Commun (Camb)· October 2023

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Histone Deacetylase 6 Inhibition Exploits Selective Metabolic Vulnerabilities in LKB1 Mutant, KRAS Driven NSCLC.
Hua Zhang, Christopher S Nabel, Dezhi Li, Ruth Í O'Connor, Caroline R Crosby, Daniel A Rodrigues

J Thorac Oncol· July 2023

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The path to venetoclax resistance is paved with mutations, metabolism, and more.
Graeme P Sullivan, Lyndsey Flanagan, Daniel Alencar Rodrigues, Tríona Ní Chonghaile

Sci Transl Med· December 2022

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Design, Synthesis and Pharmacological Evaluation of Novel Conformationally Restricted -arylpiperazine Derivatives Characterized as D/D Receptor Ligands, Candidates for the Treatment of Neurodegenerative Diseases.
Thayssa Tavares da Silva Cunha, Rafaela Ribeiro Silva, Daniel Alencar Rodrigues, Pedro de Sena Murteira Pinheiro, Thales Kronenberger

Biomolecules· August 2022

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Advances in the Design and Development of PROTAC-mediated HDAC Degradation.
Daniel Alencar Rodrigues, Andrew Roe, Darren Griffith, Tríona Ní Chonghaile

Curr Top Med Chem· March 2022

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Recent Advances in the Use of Multitarget Therapeutics.
Daniel Alencar Rodrigues

Curr Top Med Chem· March 2022

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Novel Single Inhibitor of HDAC6/8 and Dual Inhibitor of PI3K/HDAC6 as Potential Alternative Treatments for Prostate Cancer.
Fabiana Sélos Guerra, Daniel Alencar Rodrigues, Carlos Alberto Manssour Fraga, Patricia Dias Fernandes

Pharmaceuticals (Basel)· April 2021

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Multitarget Inhibition of Histone Deacetylase (HDAC) and Phosphatidylinositol-3-kinase (PI3K): Current and Future Prospects.
Daniel A Rodrigues, Pedro S M Pinheiro, Carlos A M Fraga

ChemMedChem· February 2021

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Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities.
Daniel A Rodrigues, Pedro de S M Pinheiro, Fernanda S Sagrillo, Maria L Bolognesi, Carlos A M Fraga

Med Res Rev· November 2020

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Design, Synthesis, and Pharmacological Evaluation of First-in-Class Multitarget N-Acylhydrazone Derivatives as Selective HDAC6/8 and PI3Kα Inhibitors.
Daniel A Rodrigues, Fabiana S Guerra, Fernanda S Sagrillo, Pedro de Sena M Pinheiro, Marina A Alves

ChemMedChem· March 2020

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The Use of Conformational Restriction in Medicinal Chemistry.
Pedro de Sena M Pinheiro, Daniel A Rodrigues, Rodolfo do Couto Maia, Sreekanth Thota, Carlos A M Fraga

Curr Top Med Chem· November 2019

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Duvelisib: A 2018 Novel FDA-Approved Small Molecule Inhibiting Phosphoinositide 3-Kinases.
Daniel A Rodrigues, Fernanda S Sagrillo, Carlos A M Fraga

Pharmaceuticals (Basel)· May 2019

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Recent Advances in Development of Polyphenols as Anticancer Agents.
Sreekanth Thota, Daniel Alencar Rodrigues, Eliezer J Barreiro

Mini Rev Med Chem· September 2018

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N-Acylhydrazones as drugs.
Sreekanth Thota, Daniel A Rodrigues, Pedro de Sena Murteira Pinheiro, Lídia M Lima, Carlos A M Fraga

Bioorg Med Chem Lett· September 2018

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Ru(II) Compounds: Next-Generation Anticancer Metallotherapeutics?
Sreekanth Thota, Daniel A Rodrigues, Debbie C Crans, Eliezer J Barreiro

J Med Chem· July 2018

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An Unusual Intramolecular Halogen Bond Guides Conformational Selection.
Roberta Tesch, Christian Becker, Matthias Philipp Müller, Michael Edmund Beck, Lena Quambusch, Daniel Alencar Rodrigues

Angew Chem Int Ed Engl· July 2018

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Structural basis for the agonist action at free fatty acid receptor 1 (FFA1R or GPR40).
Daniel Alencar Rodrigues, Pedro de Sena Murteira Pinheiro, Thayssa Tavares da Silva Cunha Ferreira, Sreekanth Thota, Carlos Alberto Manssour Fraga

Chem Biol Drug Des· March 2018

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Beyond the Selective Inhibition of Histone Deacetylase 6.
Daniel A Rodrigues, Sreekanth Thota, Carlos A M Fraga

Mini Rev Med Chem· February 2017

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Design, Synthesis, and Pharmacological Evaluation of Novel N-Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors.
Daniel A Rodrigues, Guilherme À Ferreira-Silva, Ana C S Ferreira, Renan A Fernandes, Jolie K Kwee

J Med Chem· January 2016

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