Publications by authors named "Darren Locke"

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Development of a LAG-3 immunohistochemistry assay for melanoma.
Lori Johnson, Bryan McCune, Darren Locke, Cyrus Hedvat, John B Wojcik

J Clin Pathol· September 2023

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Companion diagnostic requirements for spatial biology using multiplex immunofluorescence and multispectral imaging.
Darren Locke, Clifford C Hoyt

Front Mol Biosci· February 2023

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Multi-institutional TSA-amplified Multiplexed Immunofluorescence Reproducibility Evaluation (MITRE) Study.
Janis M Taube, Kristin Roman, Elizabeth L Engle, Chichung Wang, Carmen Ballesteros-Merino, Darren Locke

J Immunother Cancer· July 2021

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New Technologies to Image Tumors.
George McNamara, Justin Lucas, John F Beeler, Ajay Basavanhally, George Lee, Darren Locke

Cancer Treat Res· September 2020

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Quantifying drug tissue biodistribution by integrating high content screening with deep-learning analysis.
Zhuyin Li, Youping Xiao, Jia Peng, Darren Locke, Derek Holmes

Sci Rep· September 2020

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Multiplexed ion beam imaging (MIBI) for characterization of the tumor microenvironment across tumor types.
Jason Ptacek, Darren Locke, Rachel Finck, Mary-Ellen Cvijic, Zhuyin Li

Lab Invest· August 2020

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Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors.
Kurt A Schalper, Michael Carleton, Ming Zhou, Tian Chen, Ye Feng, Darren Locke

Nat Med· May 2020

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Effects of tumor grade and dexamethasone on myeloid cells in patients with glioma.
Kara W Moyes, Amira Davis, Virginia Hoglund, Kristen Haberthur, Nicole Ap Lieberman, Darren Locke

Oncoimmunology· August 2018

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Development of a Prototype Immunohistochemistry Assay to Measure Programmed Death Ligand-1 Expression in Tumor Tissue.
Marisa Dolled-Filhart, Darren Locke, Tiffany Murphy, Frank Lynch, Jennifer H Yearley

Arch Pathol Lab Med· November 2016

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Differential gene expression in cholesteatoma by DNA chip analysis.
John D Macias, Richard D Gerkin, Darren Locke, Mimi P Macias

Laryngoscope· October 2013

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Mechanism for modulation of gating of connexin26-containing channels by taurine.
Darren Locke, Fabien Kieken, Liang Tao, Paul L Sorgen, Andrew L Harris

J Gen Physiol· September 2011

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Post-translational modifications of connexin26 revealed by mass spectrometry.
Darren Locke, Shengjie Bian, Hong Li, Andrew L Harris

Biochem J· December 2009

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Biological and biophysical properties of vascular connexin channels.
Scott Johnstone, Brant Isakson, Darren Locke

Int Rev Cell Mol Biol· December 2009

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Connexin channels and phospholipids: association and modulation.
Darren Locke, Andrew L Harris

BMC Biol· August 2009

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Nature of Cx30-containing channels in the adult mouse mammary gland.
Darren Locke, Susan Jamieson, Torsten Stein, Jade Liu, Malcolm B Hodgins

Cell Tissue Res· April 2007

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Hydrostatic low-range pressure applications of the Paris-Edinburgh cell utilizing polymer gaskets for diffuse X-ray scattering measurements.
Karena W Chapman, Peter J Chupas, Charles A Kurtz, Darren R Locke, John B Parise

J Appl Crystallogr· February 2007

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Heteromeric, but not homomeric, connexin channels are selectively permeable to inositol phosphates.
Wafaa A Ayad, Darren Locke, Irina V Koreen, Andrew L Harris

J Biol Chem· June 2006

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Isoelectric points and post-translational modifications of connexin26 and connexin32.
Darren Locke, Irina V Koreen, Andrew L Harris

FASEB J· June 2006

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Lipid rafts prepared by different methods contain different connexin channels, but gap junctions are not lipid rafts.
Darren Locke, Jade Liu, Andrew L Harris

Biochemistry· October 2005

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Open pore block of connexin26 and connexin32 hemichannels by neutral, acidic and basic glycoconjugates.
Darren Locke, Lai-Xi Wang, Carville G Bevans, Yuan C Lee, Andrew L Harris

Cell Commun Adhes· November 2004

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Altered permeability and modulatory character of connexin channels during mammary gland development.
Darren Locke, Torsten Stein, Claire Davies, Joanna Morris, Andrew L Harris

Exp Cell Res· August 2004

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Reversible pore block of connexin channels by cyclodextrins.
Darren Locke, Irina V Koreen, Jade Yu Liu, Andrew L Harris

J Biol Chem· May 2004

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Neutral, acidic, and basic derivatives of anthranilamide that confer different formal charge to reducing oligosaccharides.
Darren Locke, Carville G Bevans, Lai Xi Wang, Ye Zhang, Andrew L Harris

Carbohydr Res· January 2004

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Fc Rgamma -independent signaling by the platelet collagen receptor glycoprotein VI.
Darren Locke, Changdong Liu, Xiaohui Peng, Hong Chen, Mark L Kahn

J Biol Chem· April 2003

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Lipid rafts orchestrate signaling by the platelet receptor glycoprotein VI.
Darren Locke, Hong Chen, Ying Liu, Changdong Liu, Mark L Kahn

J Biol Chem· May 2002

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