Publications by authors named "Darren Phillips"

Claim this Profile
L
Lipid Composition Alters Ferroptosis Sensitivity.
Vivian S Park, Lauren E Pope, Justin P Ingram, Grace A Alchemy, Julie J Purkal, Darren C Phillips

Cancer Res· November 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Targeting tumor intrinsic TAK1 engages TNF-α-driven cell death through distinct mechanisms and enhances cancer immunotherapy.
Jason D Huska, Kelly J Doyle, Julie J Purkal, Cara L Hrusch, Ryan C Duggan, Darren C Phillips

Cell Death Dis· October 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
L
Lipid composition differentiates ferroptosis sensitivity between and systems.
Vivian S Park, Lauren E Pope, Justin Ingram, Grace A Alchemy, Julie Purkal, Darren C Phillips

bioRxiv· November 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
BCL-X-targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors.
Andrew S Judd, Bhupinder Bawa, Wayne R Buck, Zhi-Fu Tao, Yingchun Li, Darren C Phillips, Andrew Phillips

Sci Adv· October 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients.
Junichiro Yuda, Christine Will, Darren C Phillips, Linu Abraham, Cory Alvey

Commun Med (Lond)· October 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Activity of eftozanermin alfa plus venetoclax in preclinical models and patients with acute myeloid leukemia.
Stephen K Tahir, Emiliano Calvo, Benedito A Carneiro, Junichiro Yuda, Aditya Shreenivas, Darren C Phillips

Blood· April 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pevonedistat and azacitidine upregulate NOXA (PMAIP1) to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia.
Dan Cojocari, Brianna N Smith, Julie J Purkal, Maria P Arrate, Jason D Huska, Darren C Phillips

Haematologica· April 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Enasidenib-induced differentiation promotes sensitivity to venetoclax in IDH2-mutated acute myeloid leukemia.
Severine Cathelin, David Sharon, Amit Subedi, Dan Cojocari, Darren C Phillips

Leukemia· March 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
MCL1 nuclear translocation induces chemoresistance in colorectal carcinoma.
Dechen Fu, Luke Pfannenstiel, Abeba Demelash, Yee Peng Phoon, Cameron Mayell, Darren C Phillips

Cell Death Dis· January 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors.
Yunsong Tong, Alan S Florjancic, Rick F Clark, Chunqiu Lai, Anthony Mastracchio, Darren C Phillips

ACS Med Chem Lett· July 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
Hexavalent TRAIL Fusion Protein Eftozanermin Alfa Optimally Clusters Apoptosis-Inducing TRAIL Receptors to Induce On-Target Antitumor Activity in Solid Tumors.
Darren C Phillips, Fritz G Buchanan, Dong Cheng, Larry R Solomon, Yu Xiao

Cancer Res· June 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers.
Ahmed Hamed Salem, Zhi-Fu Tao, Orlando F Bueno, Jie Chen, Shuang Chen, Darren C Phillips

Mol Cancer Ther· June 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure-Based Design of A-1293102, a Potent and Selective BCL-X Inhibitor.
Zhi-Fu Tao, Xilu Wang, Jun Chen, Justin P Ingram, Sha Jin, Darren C Phillips

ACS Med Chem Lett· June 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X Inhibitor.
Le Wang, George A Doherty, Andrew S Judd, Zhi-Fu Tao, T Matthew Hansen, Darren C Phillips

ACS Med Chem Lett· October 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
5
5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-Mediated Apoptosis.
Sha Jin, Dan Cojocari, Julie J Purkal, Relja Popovic, Nari N Talaty, Darren C Phillips

Clin Cancer Res· July 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Inhibition of cyclin-dependent kinase 9 synergistically enhances venetoclax activity in mantle cell lymphoma.
Xiaoxian Zhao, Juraj Bodo, Ruoying Chen, Lisa Durkin, Andrew J Souers, Darren C Phillips

EJHaem· July 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies.
Darren C Phillips, Sha Jin, Gareth P Gregory, Qi Zhang, John Xue

Leukemia· June 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models.
Lina Han, Qi Zhang, Monique Dail, Ce Shi, Antonio Cavazos, Darren C Phillips

Haematologica· March 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Selective Primary Alcohol Oxidation of Lignin Streams from Butanol-Pretreated Agricultural Waste Biomass.
Isabella Panovic, Christopher S Lancefield, Darren Phillips, Mark J Gronnow, Nicholas J Westwood

ChemSusChem· January 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Acquired resistance to venetoclax (ABT-199) in t(14;18) positive lymphoma cells.
Juraj Bodo, Xiaoxian Zhao, Lisa Durkin, Andrew J Souers, Darren C Phillips

Oncotarget· October 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor.
Yu Xiao, Paul Nimmer, George S Sheppard, Milan Bruncko, Paul Hessler, Darren C Phillips

Mol Cancer Ther· August 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Correction to Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity.
Milan Bruncko, Le Wang, George S Sheppard, Darren C Phillips, Stephen K Tahir

J Med Chem· May 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.
Milan Bruncko, Le Wang, George S Sheppard, Darren C Phillips, Stephen K Tahir

J Med Chem· March 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.
Joel D Leverson, Darren C Phillips, Michael J Mitten, Erwin R Boghaert, Dolores Diaz

Sci Transl Med· March 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
Zhi-Fu Tao, Lisa Hasvold, Le Wang, Xilu Wang, Andrew M Petros, Darren C Phillips

ACS Med Chem Lett· October 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis