Publications by authors named "Darren Yuen"

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Efficacy, Mechanisms and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Kidney Transplant Recipients: A Randomized, Double-Blind, Placebo-Controlled Trial.
Vikas S Sridhar, Luxcia Kugathasan, Yuliya Lytvyn, Hongyan Liu, Yangqing Deng, Darren A Yuen

Clin J Am Soc Nephrol· December 2025

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ANTXR1 blockade enhances cardiac function in preclinical models of heart failure.
Nicola Boccella, GuoJun Yu, Steven Seaman, Yang Feng, Jaewon Lee, Darren A Yuen

Nat Cardiovasc Res· November 2025

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Development and Evaluation of a Kidney Point-Of-Care Ultrasound (POCUS) Training Program for Nephrology Fellows: A Quality Improvement Study.
Tony Fang, Mohammad Azfar Qureshi, Sara S Jdiaa, Abdelhamid Aboghanem, Klement Yeung, Darren A Yuen

Can J Kidney Health Dis· November 2025

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Biphasic actions of the adenosine A2a receptor antagonist istradefylline in mice with obstructive uropathy.
Emily S H Yeung, Duc Tin Tran, Sri Nagarjun Batchu, Suzanne L Advani, Youan Liu, Darren A Yuen

Sci Rep· November 2025

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The enzyme SMPDL3b in podocytes decouples proteinuria from chronic kidney disease progression in experimental Alport Syndrome.
Alla Mitrofanova, Antonio M Fontanella, Judith Molina, Guanshi Zhang, Shamroop K Mallela, Darren A Yuen

Kidney Int· August 2025

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Induction of proximal tubular proliferation and lengthening in response to sodium glucose linked cotransporter-2 inhibition in experimental rats.
Ellen Wu, Sarah Macklin, Yanling Zhang, Kerri Thai, Linda Nghiem, Darren A Yuen

J Diabetes Investig· July 2025

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Podocyte YAP and TAZ hyperactivation drives glomerular epithelial proliferative diseases in mice and humans.
Xiaolin He, Estefania Rodriguez Ballestas, Li Zeng, Tianzhou Zhang, Caitriona M McEvoy, Darren A Yuen

Sci Transl Med· June 2025

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A first-in-human study of quantitative ultrasound to assess transplant kidney fibrosis.
Eno Hysi, Jihye Baek, Alexander Koven, Xiaolin He, Luisa Ulloa Severino, Darren A Yuen

Nat Med· March 2025

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Myocardial Extracellular Volume Fraction Varies With Hemodynamic Load and After Pulmonary Valve Replacement in TOF.
Ayako Ishikita, Gauri R Karur, Kate Hanneman, Darren A Yuen, Rajiv R Chaturvedi

JACC Cardiovasc Imaging· July 2024

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Not too much, not too little-just the right amount: the story of YAP in the podocyte.
Caitríona M McEvoy, Darren A Yuen

Kidney Int· June 2024

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Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation.
Cynthia T Luk, Carmen K Chan, Felix Chiu, Sally Yu Shi, Paraish S Misra, Darren A Yuen

Diabetes· December 2023

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Omicron variant neutralizing antibodies following BNT162b2 BA.4/5 versus mRNA-1273 BA.1 bivalent vaccination in patients with end-stage kidney disease.
Kevin Yau, Alexandra Kurtesi, Freda Qi, Melanie Delgado-Brand, Tulunay R Tursun, Darren A Yuen

Nat Commun· September 2023

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Humoral Responses in the Omicron Era Following 3-Dose SARS-CoV-2 Vaccine Series in Kidney Transplant Recipients.
Caitríona M McEvoy, Queenie Hu, Kento T Abe, Kevin Yau, Matthew J Oliver, Darren A Yuen

Transplant Direct· January 2023

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Disruption of adipocyte YAP improves glucose homeostasis in mice and decreases adipose tissue fibrosis.
Daniel J Han, Rukhsana Aslam, Paraish S Misra, Felix Chiu, Tanvi Ojha, Darren A Yuen

Mol Metab· December 2022

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Magnetic Resonance Elastography-derived Stiffness Predicts Renal Function Loss and Is Associated With Microvascular Inflammation in Kidney Transplant Recipients.
Anwar S Shatil, Anish Kirpalani, Eyesha Younus, Pascal N Tyrrell, Adriana Krizova, Darren A Yuen

Transplant Direct· June 2022

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Real-world Impact of 2-dose SARS-CoV-2 Vaccination in Kidney Transplant Recipients.
Caitríona M McEvoy, Anna Lee, Paraish S Misra, Gerald Lebovic, Ron Wald, Darren A Yuen

Transplantation· May 2022

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NUAK1 promotes organ fibrosis via YAP and TGF-β/SMAD signaling.
Tianzhou Zhang, Xiaolin He, Lauren Caldwell, Santosh Kumar Goru, Luisa Ulloa Severino, Darren A Yuen

Sci Transl Med· March 2022

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Myofibroblast YAP/TAZ activation is a key step in organ fibrogenesis.
Xiaolin He, Monica F Tolosa, Tianzhou Zhang, Santosh Kumar Goru, Luisa Ulloa Severino, Darren A Yuen

JCI Insight· February 2022

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Microfluidic Generation of Monodisperse Nanobubbles by Selective Gas Dissolution.
Jiang Xu, Alinaghi Salari, Yanjie Wang, Xiaolin He, Liam Kerr, Darren Yuen

Small· May 2021

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Inhibition of polar actin assembly by astral microtubules is required for cytokinesis.
Anan Chen, Luisa Ulloa Severino, Thomas C Panagiotou, Trevor F Moraes, Darren A Yuen

Nat Commun· April 2021

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Overexpression of the Severe Acute Respiratory Syndrome Coronavirus-2 Receptor, Angiotensin-Converting Enzyme 2, in Diabetic Kidney Disease: Implications for Kidney Injury in Novel Coronavirus Disease 2019.
Richard E Gilbert, Lauren Caldwell, Paraish S Misra, Kin Chan, Kevin D Burns, Darren A Yuen

Can J Diabetes· March 2021

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Reduced Flow in Delayed Graft Function as Assessed by IVIM Is Associated With Time to Recovery Following Kidney Transplantation.
Eyesha Hashim, Darren A Yuen, Anish Kirpalani

J Magn Reson Imaging· January 2021

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Imaging of renal fibrosis.
Eno Hysi, Darren A Yuen

Curr Opin Nephrol Hypertens· November 2020

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Renal histology in diabetic nephropathy predicts progression to end-stage kidney disease but not the rate of renal function decline.
Paraish S Misra, Stephen G Szeto, Adriana Krizova, Richard E Gilbert, Darren A Yuen

BMC Nephrol· July 2020

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Validation of the Kidney Failure Risk Equation in Kidney Transplant Recipients.
Navdeep Tangri, Thomas W Ferguson, Chris Wiebe, Frederick Eng, Michelle Nash, Darren A Yuen

Can J Kidney Health Dis· May 2020

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