Publications by authors named "Darryl Overby"

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Scientific Concerns About Recent Fluid-Structure Interaction Models of the Aqueous Humor Outflow Pathway.
Mark Johnson, Darryl R Overby, W Daniel Stamer, C Ross Ethier

Invest Ophthalmol Vis Sci· December 2025

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Endothelial cell stiffness and type drive the formation of biomechanically induced transcellular pores.
Seyed Mohammad Siadat, Haiyan Li, Brigid Millette, Babak N Safa, Cydney A Wong, Darryl R Overby

Cell Rep· December 2025

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Mechano- and Glucocorticoid-Sensitive TREK-1 Channels Regulate Conventional Outflow and Intraocular Pressure.
Sarah N Redmon, Oleg Yarishkin, Christopher N Rudzitis, Monika Lakk, Jacques Bertrand, Darryl R Overby

Invest Ophthalmol Vis Sci· November 2025

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Transient receptor potential vanilloid 4 modulates substrate stiffness mechanosensing and transcellular pore formation in human Schlemm's canal cells.
Haiyan Li, Cydney Wong, Seyed Mohammad Siadat, Kristin M Perkumas, Jacques A Bertrand, Darryl R Overby

Acta Biomater· September 2025

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Corticosteroids elevate intraocular pressure through suppression of TREK-1 signaling.
Sarah N Redmon, Oleg Yarishkin, Christopher N Rudzitis, Monika Lakk, Jacques Bertrand, Darryl R Overby

bioRxiv· August 2025

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TRPV4 modulates substrate stiffness mechanosensing and transcellular pore formation in human Schlemm's canal cells.
Haiyan Li, Cydney Wong, Seyed Mohammad Siadat, Kristin M Perkumas, Jacques A Bertrand, Darryl R Overby

bioRxiv· May 2025

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A Model of the Mechanisms Underpinning Unconventional Aqueous Humor Outflow.
Jennifer H Tweedy, Mariia Dvoriashyna, Jessica R Crawshaw, Darryl R Overby, Rodolfo Repetto

Invest Ophthalmol Vis Sci· April 2025

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Endothelial cell-specific postnatal deletion of Nos3 preserves intraocular pressure homeostasis via macrophage recruitment and NOS2 upregulation.
Ruth A Kelly, Megan S Kuhn, Ester Reina-Torres, Revathi Balasubramanian, Kristin M Perkumas, Darryl R Overby

J Clin Invest· February 2025

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Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches.
Ted S Acott, Michael P Fautsch, Weiming Mao, C Ross Ethier, Alex S Huang, Darryl R Overby

Invest Ophthalmol Vis Sci· December 2024

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Consensus Statement on Brillouin Light Scattering Microscopy of Biological Materials.
Pierre Bouvet, Carlo Bevilacqua, Yogeshwari Ambekar, Giuseppe Antonacci, Joshua Au, Darryl R Overby

ArXiv· November 2024

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Endothelial cell stiffness and type drive the formation of biomechanically-induced transcellular pores.
Seyed Mohammad Siadat, Haiyan Li, Brigid A Millette, Babak N Safa, Cydney A Wong, Darryl R Overby

bioRxiv· October 2024

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The Factors Affecting the Stability of IOP Homeostasis.
Darryl R Overby, C Ross Ethier, Changxu Miao, Ruth A Kelly, Ester Reina-Torres

Invest Ophthalmol Vis Sci· June 2024

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Pressure Clamping During Ocular Perfusions Drives Nitric Oxide-Mediated Washout.
Ruth A Kelly, Fiona S McDonnell, Michael L De Ieso, Darryl R Overby, W Daniel Stamer

Invest Ophthalmol Vis Sci· June 2023

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Model of inverse bleb growth explains giant vacuole dynamics during cell mechanoadaptation.
Andrea Cairoli, Alice Spenlehauer, Darryl R Overby, Chiu Fan Lee

PNAS Nexus· February 2023

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Segmental outflow dynamics in the trabecular meshwork of living mice.
Ester Reina-Torres, Tiffany M G Baptiste, Darryl R Overby

Exp Eye Res· December 2022

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Measurement of postmortem outflow facility using iPerfusion.
Michael Madekurozwa, Ester Reina-Torres, Darryl R Overby, Joseph van Batenburg-Sherwood

Exp Eye Res· July 2022

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Emergent Temporal Signaling in Human Trabecular Meshwork Cells: Role of TRPV4-TRPM4 Interactions.
Oleg Yarishkin, Tam T T Phuong, Felix Vazquez-Chona, Jacques Bertrand, Joseph van Battenburg-Sherwood, Darryl Overby

Front Immunol· April 2022

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Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.
Colleen M McDowell, Krishnakumar Kizhatil, Michael H Elliott, Darryl R Overby, Joseph van Batenburg-Sherwood

Invest Ophthalmol Vis Sci· February 2022

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The role of EP receptors in mediating the ultra-long-lasting intraocular pressure reduction by JV-GL1.
Jacques A Bertrand, David F Woodward, Joseph M Sherwood, Jenny W Wang, Darryl R Overby

Br J Ophthalmol· November 2021

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The vital role for nitric oxide in intraocular pressure homeostasis.
Ester Reina-Torres, Michael L De Ieso, Louis R Pasquale, Michael Madekurozwa, Joseph van Batenburg-Sherwood, Darryl R Overby

Prog Retin Eye Res· July 2021

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The ocular pulse decreases aqueous humor outflow resistance by stimulating nitric oxide production.
Michael Madekurozwa, W Daniel Stamer, Ester Reina-Torres, Joseph M Sherwood, Darryl R Overby

Am J Physiol Cell Physiol· April 2021

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siRNA targeting Schlemm's canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model.
Paul S Cassidy, Ruth A Kelly, Ester Reina-Torres, Joseph M Sherwood, Marian M Humphries, Darryl R Overby

Mol Ther Methods Clin Dev· March 2021

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Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure.
Jacques A Bertrand, David F Woodward, Joseph M Sherwood, Alice Spenlehauer, Cristoforo Silvestri, Darryl R Overby

Prostaglandins Leukot Essent Fatty Acids· February 2021

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The role of Piezo1 in conventional aqueous humor outflow dynamics.
Wei Zhu, Fei Hou, Jingwang Fang, Mohammad Reza Bahrani Fard, Yani Liu, Darryl R Overby

iScience· February 2021

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and Are Putative Modulators of Corneoscleral Stiffness.
Elizabeth M Boazak, Rebecca King, Jiaxing Wang, Cassandra M Chu, Aaron M Toporek, Darryl R Overby

Front Bioeng Biotechnol· February 2021

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