Publications by authors named "Darryle D Schoepp"

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mGlu2/3 receptor agonist (LY354740) in anxiety.
Darryle D Schoepp

Pharmacol Biochem Behav· September 2024

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Cortical influences of serotonin and glutamate on layer V pyramidal neurons.
Gerard J Marek, Darryle D Schoepp

Prog Brain Res· October 2021

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Metabotropic glutamate receptors, 5 years on.
Graham L Collingridge, Denise Manahan-Vaughan, Ferdinando Nicoletti, Darryle D Schoepp

Neuropharmacology· March 2017

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Alzheimer's disease research and development: a call for a new research roadmap.
Howard H Feldman, Magali Haas, Sam Gandy, Darryle D Schoepp, Alan J Cross

Ann N Y Acad Sci· April 2014

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CNS distribution of metabotropic glutamate 2 and 3 receptors: transgenic mice and [³H]LY459477 autoradiography.
Rebecca A Wright, Bryan G Johnson, Ce Zhang, Craig Salhoff, Ann E Kingston, Darryle D Schoepp

Neuropharmacology· March 2013

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Where will new neuroscience therapies come from?
Darryle D Schoepp

Nat Rev Drug Discov· September 2011

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Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039).
Matthew J Fell, Kjell A Svensson, Bryan G Johnson, Darryle D Schoepp

J Pharmacol Exp Ther· July 2008

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Efficacy and tolerability of an mGlu2/3 agonist in the treatment of generalized anxiety disorder.
Eduardo Dunayevich, Janelle Erickson, Louise Levine, Ronald Landbloom, Darryle D Schoepp

Neuropsychopharmacology· June 2008

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Schizophrenia: moving beyond monoamine antagonists.
P Jeffrey Conn, Carol Tamminga, Darryle D Schoepp, Craig Lindsley

Mol Interv· April 2008

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Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial.
Sandeep T Patil, Lu Zhang, Ferenc Martenyi, Stephen L Lowe, Kimberley A Jackson, Darryle D Schoepp

Nat Med· September 2007

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In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders.
Linda M Rorick-Kehn, Bryan G Johnson, Karen M Knitowski, Craig R Salhoff, Jeffrey M Witkin, Darryle D Schoepp

Psychopharmacology (Berl)· July 2007

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Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039).
Linda M Rorick-Kehn, Bryan G Johnson, Jennifer L Burkey, Rebecca A Wright, David O Calligaro, Darryle D Schoepp

J Pharmacol Exp Ther· April 2007

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Metabotropic glutamate receptors in the control of mood disorders.
Jeffrey M Witkin, Gerard J Marek, Bryan G Johnson, Darryle D Schoepp

CNS Neurol Disord Drug Targets· April 2007

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Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identification of potent, selective, and orally bioavailable agonists for mGlu2/3 receptors.
James A Monn, Steven M Massey, Matthew J Valli, Steven S Henry, Gregory A Stephenson, Darryle D Schoepp

J Med Chem· January 2007

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The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats.
Zachary A Rodd, David L McKinzie, Richard L Bell, Victoria K McQueen, James M Murphy, Darryle D Schoepp

Behav Brain Res· August 2006

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Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus.
Anni-Maija Linden, Melvin Baez, Marcelle Bergeron, Darryle D Schoepp

Neuropharmacology· August 2006

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5-Hydroxytryptamine2A (5-HT2A) receptor regulation in rat prefrontal cortex: interaction of a phenethylamine hallucinogen and the metabotropic glutamate2/3 receptor agonist LY354740.
Gerard J Marek, Rebecca A Wright, Darryle D Schoepp

Neurosci Lett· August 2006

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Improved bioavailability of the mGlu2/3 receptor agonist LY354740 using a prodrug strategy: in vivo pharmacology of LY544344.
Linda M Rorick-Kehn, Everett J Perkins, Karen M Knitowski, John C Hart, Bryan G Johnson, Darryle D Schoepp

J Pharmacol Exp Ther· February 2006

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C3'-cis-Substituted carboxycyclopropyl glycines as metabotropic glutamate 2/3 receptor agonists: synthesis and SAR studies.
Rosario González, Iván Collado, Beatriz López de Uralde, Alicia Marcos, Luisa M Martín-Cabrejas, Darryle D Schoepp

Bioorg Med Chem· December 2005

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Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.
John R Cirrito, Kelvin A Yamada, Mary Beth Finn, Robert S Sloviter, Kelly R Bales, Darryle D Schoepp

Neuron· December 2005

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Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist.
Ana Belén Bueno, Iván Collado, Alfonso de Dios, Carmen Domínguez, José Alfredo Martín, Darryle D Schoepp

J Med Chem· August 2005

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Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate receptors: identification of a subtype selective mGlu2 receptor agonist.
Carmen Dominguez, Lourdes Prieto, Matthew J Valli, Steven M Massey, Mark Bures, Darryle D Schoepp

J Med Chem· May 2005

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Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s).
Michael P Johnson, David Barda, Thomas C Britton, Renee Emkey, William J Hornback, Darryle D Schoepp

Psychopharmacology (Berl)· April 2005

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Metabotropic glutamate receptors as novel targets for anxiety and stress disorders.
Chad J Swanson, Mark Bures, Michael P Johnson, Anni-Maija Linden, James A Monn, Darryle D Schoepp

Nat Rev Drug Discov· February 2005

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(2S,1'S,2'R,3'R)-2(2'-Carboxy-3'-hydroxymethylcyclopropyl)glycine-[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic glutamate receptors.
William J Wheeler, Dean K Clodfelter, Ivan Collado, Palaniappan Kulanthaivel, Concepcion Pedregal, Darryle D Schoepp

Bioorg Med Chem Lett· January 2005

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