Publications by authors named "Renee Emkey"

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An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis.
Kjell A Svensson, Beverly A Heinz, John M Schaus, James P Beck, Junliang Hao, Renee Emkey

J Pharmacol Exp Ther· January 2017

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Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache.
Maria-Jesus Blanco, Dana R Benesh, James A Knobelsdorf, Albert Khilevich, Guillermo S Cortez, Renee Emkey

Bioorg Med Chem Lett· January 2017

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Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity.
Laurie B Schenkel, Philip R Olivieri, Alessandro A Boezio, Holly L Deak, Renee Emkey

J Med Chem· March 2016

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Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors.
Zihao Hua, Howard Bregman, John L Buchanan, Nagasree Chakka, Angel Guzman-Perez, Renee Emkey

J Med Chem· December 2013

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Differential selectivity of JAK2 inhibitors in enzymatic and cellular settings.
Violeta Yu, Jeanne Pistillo, Ivonne Archibeque, Josie Han Lee, Bee-Chun Sun, Renee Emkey

Exp Hematol· May 2013

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Development and implementation of a high-throughput AlphaLISA assay for identifying inhibitors of EZH2 methyltransferase.
Jeffrey R Simard, Matthew Plant, Renee Emkey, Violeta Yu

Assay Drug Dev Technol· April 2013

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Development of a homogeneous AlphaLISA ubiquitination assay using ubiquitin binding matrices as universal components for the detection of ubiquitinated proteins.
Stephen Schneider, Hao Chen, Jin Tang, Renee Emkey, Paul S Andrews

Biochim Biophys Acta· November 2012

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The R1275Q neuroblastoma mutant and certain ATP-competitive inhibitors stabilize alternative activation loop conformations of anaplastic lymphoma kinase.
Linda F Epstein, Hao Chen, Renee Emkey, Douglas A Whittington

J Biol Chem· October 2012

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The discovery and optimization of a novel class of potent, selective, and orally bioavailable anaplastic lymphoma kinase (ALK) inhibitors with potential utility for the treatment of cancer.
Richard T Lewis, Christiane M Bode, Deborah M Choquette, Michele Potashman, Karina Romero, Renee Emkey

J Med Chem· July 2012

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Development of a time-resolved fluorescence resonance energy transfer assay for cyclin-dependent kinase 4 and identification of its ATP-noncompetitive inhibitors.
Mei-Chu Lo, Rachel Ngo, Kang Dai, Cong Li, Lingming Liang, Renee Emkey

Anal Biochem· February 2012

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Rapid development of piperidine carboxamides as potent and selective anaplastic lymphoma kinase inhibitors.
Marian C Bryan, Douglas A Whittington, Elizabeth M Doherty, James R Falsey, Alan C Cheng, Renee Emkey

J Med Chem· February 2012

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High-throughput TR-FRET assays for identifying inhibitors of LSD1 and JMJD2C histone lysine demethylases.
Violeta Yu, Tanja Fisch, Alexander M Long, Jin Tang, Josie Han Lee, Renee Emkey

J Biomol Screen· January 2012

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Discovery of potent and highly selective thienopyridine Janus kinase 2 inhibitors.
Laurie B Schenkel, Xin Huang, Alan Cheng, Holly L Deak, Elizabeth Doherty, Renee Emkey

J Med Chem· December 2011

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Comparison of 2 cell-based phosphoprotein assays to support screening and development of an ALK inhibitor.
Allison E Drew, Samer Al-Assaad, Violeta Yu, Paul Andrews, Patricia Merkel, Renee Emkey

J Biomol Screen· February 2011

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Identification of substrates of SMURF1 ubiquitin ligase activity utilizing protein microarrays.
Paul S Andrews, Steve Schneider, Evelyn Yang, Mark Michaels, Hao Chen, Renee Emkey

Assay Drug Dev Technol· August 2010

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Screening G protein-coupled receptors: measurement of intracellular calcium using the fluorometric imaging plate reader.
Renee Emkey, Nancy B Rankl

Methods Mol Biol· September 2009

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Discovery of alpha-amidosulfones as potent and selective agonists of CB2: synthesis, SAR, and pharmacokinetic properties.
Isaac E Marx, Erin F DiMauro, Alan Cheng, Renee Emkey, Stephen A Hitchcock

Bioorg Med Chem Lett· January 2009

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Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2.
Erin F DiMauro, John L Buchanan, Alan Cheng, Renee Emkey, Stephen A Hitchcock

Bioorg Med Chem Lett· August 2008

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Discovery and optimization of a novel series of N-arylamide oxadiazoles as potent, highly selective and orally bioavailable cannabinoid receptor 2 (CB2) agonists.
Yuan Cheng, Brian K Albrecht, James Brown, John L Buchanan, William H Buckner, Renee Emkey

J Med Chem· August 2008

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Optimization and utilization of the SureFire phospho-STAT5 assay for a cell-based screening campaign.
Christina Binder, Amy Lafayette, Ivonne Archibeque, Yu Sun, Cherylene Plewa, Renee Emkey

Assay Drug Dev Technol· February 2008

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Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators.
Lisa M Broad, Ruud Zwart, Kathy H Pearson, Martin Lee, Louise Wallace, Renee Emkey

J Pharmacol Exp Ther· September 2006

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Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A.
Youyan Zhang, Robert J Schmidt, Patricia Foxworthy, Renee Emkey, Jennifer K Oler

Biochem Biophys Res Commun· August 2005

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Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s).
Michael P Johnson, David Barda, Thomas C Britton, Renee Emkey, William J Hornback

Psychopharmacology (Berl)· April 2005

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