Publications by authors named "Matthew Plant"

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Kinetic analysis of antibody binding to integral membrane proteins stabilized in SMALPs.
Pooja Sharma, Matthew Plant, Sheung Kwan Lam, Qing Chen

BBA Adv· August 2021

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Applications of parallel synthetic lead hopping and pharmacophore-based virtual screening in the discovery of efficient glycine receptor potentiators.
Nagasree Chakka, Kristin L Andrews, Loren M Berry, Howard Bregman, Hakan Gunaydin, Matthew H Plant

Eur J Med Chem· September 2017

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Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators.
Xin Huang, Paul L Shaffer, Shawn Ayube, Howard Bregman, Hao Chen, Matthew H Plant

Nat Struct Mol Biol· February 2017

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The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors.
Howard Bregman, Jeffrey R Simard, Kristin L Andrews, Shawn Ayube, Hao Chen, Matthew H Plant

J Med Chem· February 2017

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Sphingosine kinase activity is not required for tumor cell viability.
Karen Rex, Shawn Jeffries, Matthew L Brown, Timothy Carlson, Angela Coxon, Matthew Plant

PLoS One· February 2014

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Structure guided design of a series of sphingosine kinase (SphK) inhibitors.
Darin J Gustin, Yihong Li, Matthew L Brown, Xiaoshan Min, Mike J Schmitt, Matthew Plant

Bioorg Med Chem Lett· August 2013

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Development and implementation of a high-throughput AlphaLISA assay for identifying inhibitors of EZH2 methyltransferase.
Jeffrey R Simard, Matthew Plant, Renee Emkey, Violeta Yu

Assay Drug Dev Technol· April 2013

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Screening for lysine-specific demethylase-1 inhibitors using a label-free high-throughput mass spectrometry assay.
Matthew Plant, Tom Dineen, Alan Cheng, Alexander M Long, Hao Chen

Anal Biochem· December 2011

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Discovery of pyridazinopyridinones as potent and selective p38 mitogen-activated protein kinase inhibitors.
Bin Wu, Hui-Ling Wang, Liping Pettus, Ryan P Wurz, Elizabeth M Doherty, Matthew H Plant

J Med Chem· September 2010

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Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase.
Liping H Pettus, Ryan P Wurz, Shimin Xu, Brad Herberich, Bradley Henkle, Matthew H Plant

J Med Chem· April 2010

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Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase.
Ryan P Wurz, Liping H Pettus, Bradley Henkle, Lisa Sherman, Matthew Plant

Bioorg Med Chem Lett· March 2010

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Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase.
Ryan P Wurz, Liping H Pettus, Shimin Xu, Bradley Henkle, Lisa Sherman, Matthew Plant

Bioorg Med Chem Lett· August 2009

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3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase.
Liping H Pettus, Shimin Xu, Guo-Qiang Cao, Partha P Chakrabarti, Robert M Rzasa, Matthew H Plant

J Med Chem· October 2008

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Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold.
Brad Herberich, Guo-Qiang Cao, Partha P Chakrabarti, James R Falsey, Liping Pettus, Matthew H Plant

J Med Chem· October 2008

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Discovery of amido-benzisoxazoles as potent c-Kit inhibitors.
Roxanne K Kunz, Shannon Rumfelt, Ning Chen, Dawei Zhang, Andrew S Tasker, Matthew Plant

Bioorg Med Chem Lett· September 2008

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Discovery of a potent and selective c-Kit inhibitor for the treatment of inflammatory diseases.
Ning Chen, Roland W Bürli, Susana Neira, Randall Hungate, Dawei Zhang, Matthew Plant

Bioorg Med Chem Lett· July 2008

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Structural and functional characterization of disulfide isoforms of the human IgG2 subclass.
Thomas M Dillon, Margaret Speed Ricci, Chris Vezina, Gregory C Flynn, Yaoqing Diana Liu, Matthew Plant

J Biol Chem· June 2008

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Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit.
Essa Hu, Andrew Tasker, Ryan D White, Roxanne K Kunz, Jason Human, Matthew Plant

J Med Chem· June 2008

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New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation.
Mike Frohn, Han Xu, Xiaoming Zou, Catherine Chang, Michele McElvaine, Matthew H Plant

Bioorg Med Chem Lett· December 2007

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High capacity homogeneous non-radioactive cortisol detection assays for human 11beta-hydroxysteroid dehydrogenase type 1.
Violeta Yu, Yanyan Tudor, Clarence Hale, Matthew Plant, Ki Won Kim

Assay Drug Dev Technol· February 2007

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Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents.
Roland W Bürli, Han Xu, Xiaoming Zou, Kristine Muller, Jennifer Golden, Matthew H Plant

Bioorg Med Chem Lett· July 2006

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Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes.
Jiandong Zhang, Timothy D Osslund, Matthew H Plant, Christi L Clogston, Rebecca E Nybo

Biochemistry· May 2005

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