Publications by authors named "Jennifer Golden"

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Restructuring Antiviral Quinazolinone Frameworks to Derive and Optimize Inhibitors of Chikungunya Virus.
Caroline M Roach, Zachary J Streblow, Yuting Zhang, Tyler J Ogorek, Alejandro Ponce-Flores, Jennifer E Golden

ACS Med Chem Lett· November 2025

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Broad spectrum antiviral BDGR-164 provides protection against lethal neurotropic alphavirus infection in mice.
Evan P Williams, Yi Xue, Dong Yang, Jasper Lee, Eunjung Kim, Jennifer E Golden

Antiviral Res· August 2025

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The antiviral BDGR-49 provides protection from lethal, neurotropic Venezuelan equine encephalitis virus intranasal infection in mice.
Evan P Williams, Yi Xue, Peter Vogel, Dong Yang, Alejandro Ponce-Flores, Jennifer E Golden

J Virol· March 2025

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Pharmacophore Establishment and Optimization of Saturated 1,6-Naphthyridine-Fused Quinazolinones that Inhibit Meningoencephalitis-Causing .
Matthew S Lish, Jillian E M McKeon, Caroline M Palmentiero, Julia M Pomeroy, Colm P Roster, Jennifer E Golden

J Med Chem· October 2024

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Synthesis and Evaluation of Benzylamine Inhibitors of Neuropathogenic "Brain-Eating" Amoeba.
Julia M Pomeroy, Muhammad M Khalifa, Jillian E Milanes, Caroline M Palmentiero, James C Morris, Jennifer E Golden

ACS Med Chem Lett· January 2024

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Mannich-Type Condensation and Domino Quinazolinone-Amidine Rearrangement Affords Ring-Fused Mackinazolinones with Anti-Amoebic Activity.
Matthew S Lish, Jillian E Milanes, Kyana M Sanders, Ilia A Guzei, James C Morris, Jennifer E Golden

Adv Synth Catal· December 2023

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Clinical and Translational Pharmacology Considerations for Anti-infectives Approved Under the FDA Animal Rule.
Zaid H Temrikar, Jennifer E Golden, Colleen B Jonsson, Bernd Meibohm

Clin Pharmacokinet· July 2023

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Efficacy of a brain-penetrant antiviral in lethal Venezuelan and eastern equine encephalitis mouse models.
Xufeng Cao, Dong Yang, Jyothi Parvathareddy, Yong-Kyu Chu, Eun Jung Kim, Jennifer E Golden

Sci Transl Med· April 2023

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Advances in the Development of Small Molecule Antivirals against Equine Encephalitic Viruses.
Tyler J Ogorek, Jennifer E Golden

Viruses· February 2023

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Dihydropyrazinoquinazolinones via S2 Sulfamidate Ring-Opening and a Sequential Quinazolinone-Amidine Rearrangement Strategy (SQuAReS).
Jhewelle N Fitz-Henley, Soren D Rozema, Jennifer E Golden

J Org Chem· November 2022

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Characterization of Glucokinases from Pathogenic Free-Living Amoebae.
Jillian E Milanes, Jimmy Suryadi, Neil P Monaghan, Elijah M Harding, Corbin S Morris, Jennifer E Golden

Antimicrob Agents Chemother· June 2022

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An Innovation 10 Years in the Making: The Stories in the Pages of .
Ryan A Altman, Annalaura Brai, Jennifer Golden, Giuseppe La Regina, Zhengqiu Li

ACS Med Chem Lett· April 2022

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Piperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones.
Michael C Ryan, Eunjung Kim, Xufeng Cao, Walter Reichard, Tyler J Ogorek, Jennifer E Golden

ACS Med Chem Lett· April 2022

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Time to 'Mind the Gap' in novel small molecule drug discovery for direct-acting antivirals for SARS-CoV-2.
Colleen B Jonsson, Jennifer E Golden, Bernd Meibohm

Curr Opin Virol· October 2021

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Diastereoselective, Multicomponent Synthesis of Pyrrolopyrazinoquinazolinones via a Tandem Quinazolinone Rearrangement/Intramolecular Ring Closure of Tautomeric ()-Benzamidines.
Victor A Jaffett, Jhewelle N Fitz-Henley, Muhammad M Khalifa, Ilia A Guzei, Jennifer E Golden

Org Lett· August 2021

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Construction of -Boc-2-Alkylaminoquinazolin-4(3)-Ones via a Three-Component, One-Pot Protocol Mediated by Copper(II) Chloride that Spares Enantiomeric Purity.
Xiaoyu Li, Jennifer E Golden

Adv Synth Catal· March 2021

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Engineering Selectivity for Reduced Toxicity of Bacterial Kinase Inhibitors Using Structure-Guided Medicinal Chemistry.
Nathan Wlodarchak, John B Feltenberger, Zhengqing Ye, Jeffrey Beczkiewicz, Rebecca Procknow, Jennifer E Golden

ACS Med Chem Lett· February 2021

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Dual-Stage Picolinic Acid-Derived Inhibitors of .
Muhammad M Khalifa, Bruno Martorelli Di Genova, Sarah G McAlpine, Gina M Gallego-Lopez, David M Stevenson, Jennifer E Golden

ACS Med Chem Lett· December 2020

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Emergence and Magnitude of ML336 Resistance in Venezuelan Equine Encephalitis Virus Depend on the Microenvironment.
Jasper Lee, Jyothi Parvathareddy, Dong Yang, Shruti Bansal, Kathryn O'Connell, Jennifer E Golden

J Virol· October 2020

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Benzamidine ML336 inhibits plus and minus strand RNA synthesis of Venezuelan equine encephalitis virus without affecting host RNA production.
Andrew M Skidmore, Robert S Adcock, Colleen B Jonsson, Jennifer E Golden, Dong-Hoon Chung

Antiviral Res· February 2020

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Divergent 2-Chloroquinazolin-4(3H)-one Rearrangement: Twisted-Cyclic Guanidine Formation or Ring-Fused N-Acylguanidines via a Domino Process.
Gang Yan, Bereket L Zekarias, Xiaoyu Li, Victor A Jaffett, Ilia A Guzei, Jennifer E Golden

Chemistry· February 2020

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Synthesis of Ring-Fused, N-Substituted 4-Quinolinones Using p-Guided, Base-Promoted Annulations with Isatoic Anhydrides: Total Synthesis of Penicinotam.
Muhammad M Khalifa, Satish Chandra Philkhana, Jennifer E Golden

J Org Chem· January 2020

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Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1.
Zachary Maben, Richa Arya, Digamber Rane, W Frank An, Shailesh Metkar, Jennifer Golden

J Med Chem· January 2020

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Efficacy of a ML336 derivative against Venezuelan and eastern equine encephalitis viruses.
Colleen B Jonsson, Xufeng Cao, Jasper Lee, Jon D Gabbard, Yong-Kyu Chu, Jennifer E Golden

Antiviral Res· July 2019

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Enzymatic and Structural Characterization of the Glucokinase.
Jillian E Milanes, Jimmy Suryadi, Jan Abendroth, Wesley C Van Voorhis, Kayleigh F Barrett, Jennifer E Golden

Antimicrob Agents Chemother· May 2019

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