Publications by authors named "Violeta Yu"

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KCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids.
Joshua E Berlind, Jesse D Lai, Cecilia Lie, Jokabeth Vicente, Kelsey Lam, Violeta Yu

Neuron· April 2025

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KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury.
Jesse D Lai, Joshua E Berlind, Gabriella Fricklas, Cecilia Lie, Jean-Paul Urenda, Violeta Yu

Cell Stem Cell· April 2024

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Discovery of pyridyl urea sulfonamide inhibitors of Na1.7.
John R Butler, Gwenaella Rescourio, Benjamin C Milgram, Robert S Foti, Thomas Kornecook, Violeta Yu

Bioorg Med Chem Lett· October 2022

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Correlation of Optical and Automated Patch Clamp Electrophysiology for Identification of Na1.7 Inhibitors.
Hongkang Zhang, Bryan D Moyer, Violeta Yu, Joseph G McGivern, Michael Jarosh

SLAS Discov· June 2020

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Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V.
Bryan D Moyer, Justin K Murray, Joseph Ligutti, Kristin Andrews, Philippe Favreau, Ruoyuan Yin, Violeta Yu

PLoS One· August 2018

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1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of Na1.7 inhibition.
Alessandro A Boezio, Kristin Andrews, Christiane Boezio, Margaret Chu-Moyer, Katrina W Copeland, Violeta Yu

Bioorg Med Chem Lett· June 2018

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The discovery of benzoxazine sulfonamide inhibitors of Na1.7: Tools that bridge efficacy and target engagement.
Daniel S La, Emily A Peterson, Christiane Bode, Alessandro A Boezio, Howard Bregman, Violeta Yu

Bioorg Med Chem Lett· August 2017

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Discovery of a biarylamide series of potent, state-dependent Na1.7 inhibitors.
Laurie B Schenkel, Erin F DiMauro, Hanh N Nguyen, Nagasree Chakka, Bingfan Du, Violeta L Yu

Bioorg Med Chem Lett· August 2017

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Sulfonamides as Selective Na1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities.
Matthew M Weiss, Thomas A Dineen, Isaac E Marx, Steven Altmann, Alessandro Boezio, Liyue Huang, Violeta Yu

J Med Chem· July 2017

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Sulfonamides as Selective Na1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity.
Russell F Graceffa, Alessandro A Boezio, Jessica Able, Steven Altmann, Loren M Berry, Liyue Huang, Violeta Yu

J Med Chem· July 2017

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Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel Na1.7.
Thomas J Kornecook, Ruoyuan Yin, Stephen Altmann, Xuhai Be, Virginia Berry, Violeta Yu

J Pharmacol Exp Ther· July 2017

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Correction to "Sulfonamides as Selective Na1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable Target Engagement".
Isaac E Marx, Thomas A Dineen, Jessica Able, Christiane Bode, Howard Bregman, Liyue Huang, Violeta Yu

ACS Med Chem Lett· March 2017

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Sulfonamides as Selective Na1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement.
Isaac E Marx, Thomas A Dineen, Jessica Able, Christiane Bode, Howard Bregman, Liyue Huang, Violeta Yu

ACS Med Chem Lett· December 2016

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Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors.
Erin F DiMauro, Stephen Altmann, Loren M Berry, Howard Bregman, Nagasree Chakka, Violeta Yu

J Med Chem· September 2016

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Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity.
Laurie B Schenkel, Philip R Olivieri, Alessandro A Boezio, Holly L Deak, Renee Emkey, Violeta L Yu

J Med Chem· March 2016

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Differential selectivity of JAK2 inhibitors in enzymatic and cellular settings.
Violeta Yu, Jeanne Pistillo, Ivonne Archibeque, Josie Han Lee, Bee-Chun Sun

Exp Hematol· May 2013

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Development and implementation of a high-throughput AlphaLISA assay for identifying inhibitors of EZH2 methyltransferase.
Jeffrey R Simard, Matthew Plant, Renee Emkey, Violeta Yu

Assay Drug Dev Technol· April 2013

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Structure-Based Design of Potent and Selective CK1γ Inhibitors.
Hongbing Huang, Lisa Acquaviva, Virginia Berry, Howard Bregman, Nagasree Chakka, Liyue Huang, Violeta Yu

ACS Med Chem Lett· December 2012

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The discovery and optimization of a novel class of potent, selective, and orally bioavailable anaplastic lymphoma kinase (ALK) inhibitors with potential utility for the treatment of cancer.
Richard T Lewis, Christiane M Bode, Deborah M Choquette, Michele Potashman, Karina Romero, Violeta L Yu

J Med Chem· July 2012

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High-throughput TR-FRET assays for identifying inhibitors of LSD1 and JMJD2C histone lysine demethylases.
Violeta Yu, Tanja Fisch, Alexander M Long, Jin Tang, Josie Han Lee

J Biomol Screen· January 2012

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Discovery of potent and highly selective thienopyridine Janus kinase 2 inhibitors.
Laurie B Schenkel, Xin Huang, Alan Cheng, Holly L Deak, Elizabeth Doherty, Violeta Yu

J Med Chem· December 2011

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Comparison of 2 cell-based phosphoprotein assays to support screening and development of an ALK inhibitor.
Allison E Drew, Samer Al-Assaad, Violeta Yu, Paul Andrews, Patricia Merkel

J Biomol Screen· February 2011

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Small molecules with potent osteogenic-inducing activity in osteoblast cells.
Chun-Ya E Han, Youping Wang, Longchuan Yu, David Powers, Xiaoling Xiong, Violeta Yu

Bioorg Med Chem Lett· March 2009

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Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology.
Jennifer H Dao, Robert J M Kurzeja, Jose M Morachis, Henrike Veith, Jeffery Lewis, Violeta Yu

Anal Biochem· January 2009

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3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase.
Liping H Pettus, Shimin Xu, Guo-Qiang Cao, Partha P Chakrabarti, Robert M Rzasa, Violeta Yu

J Med Chem· October 2008

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