Publications by authors named "David A Middleton"

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Complete removal of toxic herbicides and structural insight by a heteromolecular aggregate.
Shu-Qin Qin, Wei Xu, Run-Yi Chen, Zi-Wei Lai, Gang Chen, David A Middleton

J Hazard Mater· September 2025

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Illuminating High-Affinity ATP Binding to the Sodium-Potassium Pump Using Solid-State NMR Spectroscopy.
David A Middleton

Molecules· September 2025

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NMR studies of amyloid interactions.
David A Middleton

Prog Nucl Magn Reson Spectrosc· December 2024

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Characterization of Olive Oil Phenolic Extracts and Their Effects on the Aggregation of the Alzheimer's Amyloid-β Peptide and Tau.
Bakri Alaziqi, Liam Beckitt, David J Townsend, Jasmine Morgan, Rebecca Price, David A Middleton

ACS Omega· July 2024

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Solid-state NMR chemical shift analysis for determining the conformation of ATP bound to Na,K-ATPase in its native membrane.
David A Middleton, John Griffin, Mikael Esmann, Natalya U Fedosova

RSC Adv· November 2023

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Analysis of the orientation of cholesterol in high-density lipoprotein nanodiscs using solid-state NMR.
Sophie Lau, David A Middleton

Phys Chem Chem Phys· October 2022

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F Solid-State NMR and Vibrational Raman Characterization of Corticosteroid Drug-Lipid Membrane Interactions.
Bethany Mapley, David Townsend, John Griffin, Lorna Ashton, David A Middleton

Chempluschem· November 2021

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Sensitive Morphological Characterization of Oriented High-Density Lipoprotein Nanoparticles Using P NMR Spectroscopy.
Sophie Lau, David A Middleton

Angew Chem Int Ed Engl· October 2020

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Raman Spectroscopy with 2D Perturbation Correlation Moving Windows for the Characterization of Heparin-Amyloid Interactions.
David J Townsend, David A Middleton, Lorna Ashton

Anal Chem· October 2020

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Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin.
David Townsend, Nigel J Fullwood, Edwin A Yates, David A Middleton

Biochemistry· October 2020

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Circular Dichroism Spectroscopy Identifies the β-Adrenoceptor Agonist Salbutamol As a Direct Inhibitor of Tau Filament Formation .
David J Townsend, Barbora Mala, Eleri Hughes, Rohanah Hussain, Giuliano Siligardi, David A Middleton

ACS Chem Neurosci· July 2020

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Drug orientations within statin-loaded lipoprotein nanoparticles by F solid-state NMR.
Sophie Lau, Naomi Stanhope, John Griffin, Eleri Hughes, David A Middleton

Chem Commun (Camb)· October 2019

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Orientation of a Diagnostic Ligand Bound to Macroscopically Aligned Amyloid-β Fibrils Determined by Solid-State NMR.
David Townsend, Eleri Hughes, Katie L Stewart, John M Griffin, Sheena E Radford, David A Middleton

J Phys Chem Lett· November 2018

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Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin.
David Townsend, Eleri Hughes, Geoffrey Akien, Katie L Stewart, Sheena E Radford, David A Middleton

J Biol Chem· August 2018

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Average orientation of a fluoroaromatic molecule in lipid bilayers from DFT-informed NMR measurements of H-F dipolar couplings.
Eleri Hughes, John M Griffin, Michael P Coogan, David A Middleton

Phys Chem Chem Phys· July 2018

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Molecular Origins of the Compatibility between Glycosaminoglycans and Aβ40 Amyloid Fibrils.
Katie L Stewart, Eleri Hughes, Edwin A Yates, David A Middleton, Sheena E Radford

J Mol Biol· August 2017

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Heparin and Methionine Oxidation Promote the Formation of Apolipoprotein A-I Amyloid Comprising α-Helical and β-Sheet Structures.
David Townsend, Eleri Hughes, Rohanah Hussain, Giuliano Siligardi, Sarah Baldock, David A Middleton

Biochemistry· March 2017

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Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-β Fibrils.
Katie L Stewart, Eleri Hughes, Edwin A Yates, Geoffrey R Akien, Teng-Yi Huang, David A Middleton

J Am Chem Soc· July 2016

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Novel stereoselective bufadienolides reveal new insights into the requirements for Na(+), K(+)-ATPase inhibition by cardiotonic steroids.
Hong-Jin Tang, Li-Jun Ruan, Hai-Yan Tian, Guang-Ping Liang, Wen-Cai Ye, David A Middleton

Sci Rep· July 2016

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Long-Range Effects of Na(+) Binding in Na,K-ATPase Reported by ATP.
David A Middleton, Natalya U Fedosova, Mikael Esmann

Biochemistry· December 2015

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Comparison of the structure and function of phospholamban and the arginine-14 deficient mutant associated with dilated cardiomyopathy.
Eleri Hughes, David A Middleton

PLoS One· May 2015

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Ligand orientation in a membrane-embedded receptor site revealed by solid-state NMR with paramagnetic relaxation enhancement.
Christopher A P Whittaker, Simon G Patching, Mikael Esmann, David A Middleton

Org Biomol Chem· March 2015

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Comparisons with amyloid-β reveal an aspartate residue that stabilizes fibrils of the aortic amyloid peptide medin.
Hannah A Davies, Jillian Madine, David A Middleton

J Biol Chem· March 2015

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Structures, chemotaxonomic significance, cytotoxic and Na(+),K(+)-ATPase inhibitory activities of new cardenolides from Asclepias curassavica.
Rong-Rong Zhang, Hai-Yan Tian, Ya-Fang Tan, Tse-Yu Chung, Xiao-Hui Sun, David A Middleton

Org Biomol Chem· November 2014

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Expression and purification of the aortic amyloid polypeptide medin.
Hannah A Davies, Mark C Wilkinson, Robert P Gibson, David A Middleton

Protein Expr Purif· June 2014

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