Publications by authors named "David A Ruddy"

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Tumor-driven stromal reprogramming in the pre-metastatic lymph node.
Michelle Piquet, David A Ruddy, Viviana Cremasco, Jonathan Chang

F1000Res· October 2025

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Defensive tolerance drives the reprogramming and dysfunction of infiltrating pathogenic B cells assuring the maintenance of tolerance.
Koki Hayashi, Takahiro Yokose, Jenna Lancey, Edward S Szuter, Brandon Kwon, David A Ruddy

Res Sq· August 2025

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Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic Cancer.
Slavica Dimitrieva, Jon M Harrison, Jonathan Chang, Michelle Piquet, Mari Mino-Kenudson, David A Ruddy

Cancer Res Commun· December 2024

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Dysfunction of infiltrating cytotoxic CD8+ T cells within the graft promotes murine kidney allotransplant tolerance.
Takahiro Yokose, Edward S Szuter, Ivy Rosales, Michael T Guinn, Andrew S Liss, David A Ruddy

J Clin Invest· June 2024

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INPP5A phosphatase is a synthetic lethal target in GNAQ and GNA11-mutant melanomas.
Ahmed M O Elbatsh, Ali Amin-Mansour, Anne Haberkorn, Claudia Textor, Nicolas Ebel, David A Ruddy

Nat Cancer· March 2024

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Expressed Barcoding Enables High-Resolution Tracking of the Evolution of Drug Tolerance.
Jennifer L Cotton, Javier Estrada Diez, Vivek Sagar, Julie Chen, Michelle Piquet, David A Ruddy

Cancer Res· November 2023

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Targeting the IL1β Pathway for Cancer Immunotherapy Remodels the Tumor Microenvironment and Enhances Antitumor Immune Responses.
Rohan Diwanji, Neil A O'Brien, Jiyoung E Choi, Beverly Nguyen, Tyler Laszewski, David A Ruddy

Cancer Immunol Res· June 2023

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Exquisite Sensitivity to Dual BRG1/BRM ATPase Inhibitors Reveals Broad SWI/SNF Dependencies in Acute Myeloid Leukemia.
Florencia Rago, Lindsey Ulkus Rodrigues, Megan Bonney, Kathleen Sprouffske, Esther Kurth, David A Ruddy

Mol Cancer Res· March 2022

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Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment.
Hui Qin Wang, Iain J Mulford, Fiona Sharp, Jinsheng Liang, Sema Kurtulus, David A Ruddy

Cancer Res· June 2021

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RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation.
Matthew S Crowe, Tatiana Zavorotinskaya, Charles F Voliva, Matthew D Shirley, Yanqun Wang, David A Ruddy

Mol Cancer Res· June 2021

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A CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy.
Si-Qi Liu, Alyssa Grantham, Casey Landry, Brian Granda, Rajiv Chopra, David A Ruddy

Cancer Immunol Res· January 2021

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A Proof of Concept for Biomarker-Guided Targeted Therapy against Ovarian Cancer Based on Patient-Derived Tumor Xenografts.
Adam C Palmer, Deborah Plana, Hui Gao, Joshua M Korn, Guizhi Yang, David A Ruddy

Cancer Res· October 2020

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The Discovery of SWI/SNF Chromatin Remodeling Activity as a Novel and Targetable Dependency in Uveal Melanoma.
Florencia Rago, GiNell Elliott, Ailing Li, Kathleen Sprouffske, Grainne Kerr, David A Ruddy

Mol Cancer Ther· October 2020

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DOT1L inhibition is lethal for multiple myeloma due to perturbation of the endoplasmic reticulum stress pathway.
Caroline Dafflon, Swann Gaulis, Louise Barys, Karen Kapur, Vanessa Cornacchione, David A Ruddy

Oncotarget· March 2020

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Distinct Transcriptional Programming Drive Response to MAPK Inhibition in -Mutant Melanoma Patient-Derived Xenografts.
Tianshu Feng, Javad Golji, Ailing Li, Xiamei Zhang, David A Ruddy

Mol Cancer Ther· December 2019

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The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer.
Kimberly J Cocce, Jeff S Jasper, Taylor K Desautels, Logan Everett, Suzanne Wardell, David A Ruddy

Cell Rep· October 2019

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Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer.
Sana Raoof, Iain J Mulford, Heidie Frisco-Cabanos, Varuna Nangia, Daria Timonina, David A Ruddy

Oncogene· September 2019

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Hyperactivation of MAPK Signaling Is Deleterious to RAS/RAF-mutant Melanoma.
Grace P Leung, Tianshu Feng, Frederic D Sigoillot, Felipe C Geyer, Matthew D Shirley, David A Ruddy

Mol Cancer Res· January 2019

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Degron mediated BRM/SMARCA2 depletion uncovers novel combination partners for treatment of BRG1/SMARCA4-mutant cancers.
Florencia Rago, Matthew T DiMare, GiNell Elliott, David A Ruddy, Sosathya Sovath

Biochem Biophys Res Commun· January 2019

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Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss.
Huayang Liu, Javad Golji, Lauren K Brodeur, Franklin S Chung, Julie T Chen, David A Ruddy

Nat Med· January 2019

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BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity.
Caroline M Emery, Kelli-Ann Monaco, Ping Wang, Marissa Balak, Alyson Freeman, David A Ruddy

Mol Cancer Res· October 2017

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Correction: KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer.
Elsa Beyer Krall, Belinda Wang, Diana M Munoz, Nina Ilic, Srivatsan Raghavan, David A Ruddy

Elife· October 2017

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Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.
E Robert McDonald, Antoine de Weck, Michael R Schlabach, Eric Billy, Konstantinos J Mavrakis, David A Ruddy

Cell· July 2017

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Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human mutant neuroblastoma cell lines and xenograft models.
Hui Qin Wang, Ensar Halilovic, Xiaoyan Li, Jinsheng Liang, Yichen Cao, David A Ruddy

Elife· April 2017

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KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer.
Elsa B Krall, Belinda Wang, Diana M Munoz, Nina Ilic, Srivatsan Raghavan, David A Ruddy

Elife· February 2017

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