Publications by authors named "David B Finlay"

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Development of a Cell Membrane Conformational Cannabinoid CB Receptor Biosensor for the Detection of Synthetic Cannabinoids.
Michelle Glass, Nahid Khalajiassadi, Shuli Chen, Dharshini Ganeshan, Hannah Partington, David B Finlay

ACS Sens· October 2025

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Positive allosteric modulation of the cannabinoid CB receptor potentiates endocannabinoid signalling and changes ERK1/2 phosphorylation kinetics.
Hayley M Green, Jamie J Manning, Ian R Greig, Ruth A Ross, David B Finlay

Br J Pharmacol· October 2024

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RAMP and MRAP accessory proteins have selective effects on expression and signalling of the CB, CB, GPR18 and GPR55 cannabinoid receptors.
Nathaniel A K Glenn, David B Finlay, Emma R Carruthers, Kathleen G Mountjoy, Christopher S Walker

Br J Pharmacol· July 2024

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Insight into the mechanism of action of ORG27569 at the cannabinoid type one receptor utilising a unified mathematical model.
Hayley M Green, Liang Yang, Xiao Zhu, David B Finlay, Stephen B Duffull

Naunyn Schmiedebergs Arch Pharmacol· July 2024

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GPCR kinase subtype requirements for arrestin-2 and -3 translocation to the cannabinoid CB receptor and the consequences on G protein signalling.
Jamie J Manning, David B Finlay, Michelle Glass

Biochem Pharmacol· June 2024

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A quantitative pharmacology model for cannabinoid CB receptor mediated by Gi/Gs protein competition.
Liang Yang, David B Finlay, Hayley M Green, Xiao Zhu, Michelle Glass

Br J Pharmacol· April 2024

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Investigating selectivity and bias for G protein subtypes and β-arrestins by synthetic cannabinoid receptor agonists at the cannabinoid CB receptor.
Beth Ryalls, Monica Patel, Eric Sparkes, Samuel D Banister, David B Finlay

Biochem Pharmacol· April 2024

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Determination of the Cannabinoid CB1 Receptor's Positive Allosteric Modulator Binding Site through Mutagenesis Studies.
Hayley M Green, Daniel M J Fellner, David B Finlay, Daniel P Furkert, Michelle Glass

Pharmaceuticals (Basel)· January 2024

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Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB receptor.
Monica Patel, Natasha L Grimsey, Samuel D Banister, David B Finlay, Michelle Glass

Pharmacol Res Perspect· December 2023

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A kinetic model for positive allosteric modulator (PAM)-antagonists for the type 1 cannabinoid (CB ) receptor.
Liang Yang, Xiao Zhu, David B Finlay, Hayley Green, Michelle Glass

Br J Pharmacol· October 2023

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Signaling-specific inhibition of the CB receptor for cannabis use disorder: phase 1 and phase 2a randomized trials.
Margaret Haney, Monique Vallée, Sandy Fabre, Stephanie Collins Reed, Marion Zanese, David B Finlay

Nat Med· June 2023

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Cannabinoid 1 (CB ) receptor arrestin subtype-selectivity and phosphorylation dependence.
Jamie J Manning, Gabriel Rawcliffe, David B Finlay, Michelle Glass

Br J Pharmacol· February 2023

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The piperazine analogue para-fluorophenylpiperazine alters timing of the physiological effects of the synthetic cannabinoid receptor agonist AMB-FUBINACA, without changing its discriminative stimulus, signalling effects, or metabolism.
David B Finlay, Warwick Mackie, Hunter D J Webb, Lucy R Thomsen, Mhairi Nimick

Pharmacol Biochem Behav· February 2023

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Characterisation of AMB-FUBINACA metabolism and CB-mediated activity of its acid metabolite.
Hunter D J Webb, David B Finlay, Shuli Chen, Andrea J Vernall, Eric Sparkes

Forensic Toxicol· January 2023

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In Vitro Characterization of 6-Methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1-indole (ZCZ011) at the Type 1 Cannabinoid Receptor: Allosteric Agonist or Allosteric Modulator?
Hayley M Green, David B Finlay, Ruth A Ross, Iain R Greig, Stephen B Duffull

ACS Pharmacol Transl Sci· December 2022

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Delineating the interactions between the cannabinoid CB receptor and its regulatory effectors; β-arrestins and GPCR kinases.
Monica Patel, Christoph Matti, Natasha L Grimsey, Daniel F Legler, Jonathan A Javitch, David B Finlay

Br J Pharmacol· May 2022

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Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG-018.
David B Finlay, Thuy Nguyen, Thomas F Gamage, Shuli Chen, Daniel G Barrus

Pharmacol Res Perspect· February 2022

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Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior.
Thuy Nguyen, Thomas F Gamage, David B Finlay, Ann M Decker, Tiffany L Langston

J Med Chem· January 2022

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Exploring group size for statistical analysis of real-time signalling experiments.
Liang Yang, Xiao Zhu, David B Finlay, Michelle Glass, Stephen B Duffull

Br J Pharmacol· October 2021

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Pharmacological selection of cannabinoid receptor effectors: Signalling, allosteric modulation and bias.
Jamie J Manning, Hayley M Green, Michelle Glass, David B Finlay

Neuropharmacology· August 2021

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Rational design of cannabinoid type-1 receptor allosteric modulators: Org27569 and PSNCBAM-1 hybrids.
Thuy Nguyen, Thomas F Gamage, Ann M Decker, David B Finlay, Tiffany L Langston

Bioorg Med Chem· July 2021

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Biased agonism at the cannabinoid receptors - Evidence from synthetic cannabinoid receptor agonists.
Monica Patel, David B Finlay, Michelle Glass

Cell Signal· February 2021

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A novel allosteric modulator of the cannabinoid CB receptor ameliorates hyperdopaminergia endophenotypes in rodent models.
Catharine A Mielnik, Kim S Sugamori, David B Finlay, Hayley H A Thorpe, Matthieu Schapira

Neuropsychopharmacology· January 2021

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Evaluation of the profiles of CB cannabinoid receptor signalling bias using joint kinetic modelling.
Xiao Zhu, David B Finlay, Michelle Glass, Stephen B Duffull

Br J Pharmacol· August 2020

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Terpenoids From Cannabis Do Not Mediate an Entourage Effect by Acting at Cannabinoid Receptors.
David B Finlay, Kathleen J Sircombe, Mhairi Nimick, Callum Jones, Michelle Glass

Front Pharmacol· March 2020

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