Publications by authors named "David B MacLeod"

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Cerebral oxygen extraction across different exercise intensities: Role of arterial .
L Madden Brewster, Travis Dylan Gibbons, Hannah Grace Caldwell, Connor A Howe, Jennifer S Duffy, David B MacLeod

Exp Physiol· December 2025

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Brain glucose extraction is fixed at 10% despite twofold variability in resting cerebral blood flow in healthy humans.
Jennifer S Duffy, Hannah G Caldwell, Ryan L Hoiland, Connor A Howe, Kurt J Smith, David B MacLeod

J Cereb Blood Flow Metab· December 2025

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Preferential lactate metabolism in the human brain during exogenous and endogenous hyperlactataemia.
Jodie L Koep, Jennifer S Duffy, Jay M J R Carr, Madden L Brewster, Jordan D Bird, David B MacLeod

J Physiol· November 2025

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Characterizing the physiology of circulatory arrest in humans.
Jordan D Bird, Laura Hornby, Veronica Hirsch-Reinshagen, Chloe P Allen, George Isac, David B MacLeod

Nat Med· October 2025

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Cerebrospinal fluid pH in chronic respiratory acidosis.
Jay M J R Carr, Travis D Gibbons, David B MacLeod, Erik R Swenson, Philip N Ainslie

J Appl Physiol (1985)· July 2025

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Non-contact (touchless) monitoring of respiratory rate in a challenging anesthesia setting using a depth camera.
David B MacLeod, Philip Smit, André Antunes, Dean Montgomery, Paul S Addison

J Clin Monit Comput· July 2025

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Incidence of transient neurologic symptoms in patients receiving lidocaine spinal anesthesia for outpatient joint arthroplasty.
Sara Amaral, Emily Chen, Amanda H Kumar, David B MacLeod, W Michael Bullock

Reg Anesth Pain Med· April 2025

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Cerebral Blood Flow in Orthostatic Intolerance.
Muhammad Shahzeb Khan, Amanda J Miller, Arooba Ejaz, Jeroen Molinger, Parag Goyal, David B MacLeod

J Am Heart Assoc· February 2025

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Intense exercise at high altitude causes platelet loss across the brain in humans.
Travis Dylan Gibbons, Hannah G Caldwell, Hashim Islam, Jennifer Duffy, David B MacLeod

J Physiol· November 2024

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Severe hypoxaemic hypercapnia compounds cerebral oxidative-nitrosative stress during extreme apnoea: Implications for cerebral bioenergetic function.
Damian M Bailey, Anthony R Bain, Ryan L Hoiland, Otto F Barak, Ivan Drvis, David B MacLeod

J Physiol· November 2024

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Evidence for direct CO -mediated alterations in cerebral oxidative metabolism in humans.
Hannah G Caldwell, Ryan L Hoiland, Anthony R Bain, Connor A Howe, Jay M J R Carr, David B MacLeod

Acta Physiol (Oxf)· September 2024

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Selected and shared hematological responses to apnea in elite human free divers and northern elephant seals ().
Courtney V Brown, J Chris McKnight, Anthony R Bain, Joshua C Tremblay, Alexander Patrician, David B Macleod

Am J Physiol Regul Integr Comp Physiol· July 2024

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Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment.
Eric R Heinz, Rachel Bernardo, Sarah Elizabeth Birk, William Manson, David B MacLeod

J Vis Exp· July 2024

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Shining a light on cerebral autoregulation: Are we anywhere near the truth?
Jordan D Bird, David B MacLeod, Donald E Griesdale, Mypinder S Sekhon, Ryan L Hoiland

J Cereb Blood Flow Metab· June 2024

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Hemoglobin and cerebral hypoxic vasodilation in humans: Evidence for nitric oxide-dependent and -nitrosothiol mediated signal transduction.
Ryan L Hoiland, David B MacLeod, Benjamin S Stacey, Hannah G Caldwell, Connor A Howe

J Cereb Blood Flow Metab· September 2023

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Cerebral O and CO transport in isovolumic haemodilution: Compensation of cerebral delivery of O and maintenance of cerebrovascular reactivity to CO.
Jay Mjr Carr, Philip N Ainslie, David B MacLeod, Joshua C Tremblay, Daniela Nowak-Flück

J Cereb Blood Flow Metab· January 2023

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Hypoxemia increases blood-brain barrier permeability during extreme apnea in humans.
Damian M Bailey, Anthony R Bain, Ryan L Hoiland, Otto F Barak, Ivan Drvis, David B MacLeod

J Cereb Blood Flow Metab· June 2022

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Trans-cerebral HCO and PCO exchange during acute respiratory acidosis and exercise-induced metabolic acidosis in humans.
Hannah G Caldwell, Ryan L Hoiland, Kurt J Smith, Patrice Brassard, Anthony R Bain, David B MacLeod

J Cereb Blood Flow Metab· April 2022

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GLOBAL REACH 2018: intra-arterial vitamin C improves endothelial-dependent vasodilatory function in humans at high altitude.
Rachel M Stone, Philip N Ainslie, Joshua C Tremblay, John D Akins, David B MacLeod

J Physiol· March 2022

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Nitric oxide contributes to cerebrovascular shear-mediated dilatation but not steady-state cerebrovascular reactivity to carbon dioxide.
Ryan L Hoiland, Hannah G Caldwell, Jay M J R Carr, Connor A Howe, Benjamin S Stacey, David B MacLeod

J Physiol· March 2022

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The influence of hemoconcentration on hypoxic pulmonary vasoconstriction in acute, prolonged, and lifelong hypoxemia.
Mike Stembridge, Ryan L Hoiland, Alexandra M Williams, Connor A Howe, Joseph Donnelly, David B MacLeod

Am J Physiol Heart Circ Physiol· October 2021

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Prolonged progressive hypermetabolism during COVID-19 hospitalization undetected by common predictive energy equations.
Laura E Niederer, Hilary Miller, Krista L Haines, Jeroen Molinger, John Whittle, David B MacLeod

Clin Nutr ESPEN· October 2021

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Regulation of cerebral blood flow by arterial PCO independent of metabolic acidosis at 5050 m.
Hannah G Caldwell, Kurt J Smith, Nia C S Lewis, Ryan L Hoiland, Christopher K Willie, David B MacLeod

J Physiol· July 2021

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Influence of iron manipulation on hypoxic pulmonary vasoconstriction and pulmonary reactivity during ascent and acclimatization to 5050 m.
Christopher K Willie, Alexander Patrician, Ryan L Hoiland, Alexandra M Williams, Christopher Gasho, David B MacLeod

J Physiol· March 2021

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Reply to Drs. Wang et al.
Tiffany W Dong, David B MacLeod, Antoinette Santoro, Zachary Augustine, Stratton Barth

J Appl Physiol (1985)· October 2020

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