Publications by authors named "David Botstein"

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Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice.
Lev Litichevskiy, Maya Considine, Jasleen Gill, Vasuprada Shandar, Timothy O Cox, David Botstein

Nat Microbiol· May 2025

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Dietary restriction impacts health and lifespan of genetically diverse mice.
Andrea Di Francesco, Andrew G Deighan, Lev Litichevskiy, Zhenghao Chen, Alison Luciano, David Botstein

Nature· October 2024

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Global analysis of the yeast knockout phenome.
Gina Turco, Christie Chang, Rebecca Y Wang, Griffin Kim, Emily H Stoops, David Botstein

Sci Adv· May 2023

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Novel insights from a multiomics dissection of the Hayflick limit.
Michelle Chan, Han Yuan, Ilya Soifer, Tobias M Maile, Rebecca Y Wang, David Botstein

Elife· February 2022

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Loss of major nutrient sensing and signaling pathways suppresses starvation lethality in electron transport chain mutants.
Alisha G Lewis, Robert Caldwell, Jason V Rogers, Maria Ingaramo, Rebecca Y Wang, David Botstein

Mol Biol Cell· December 2021

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A genome-scale yeast library with inducible expression of individual genes.
Yuko Arita, Griffin Kim, Zhijian Li, Helena Friesen, Gina Turco, David Botstein

Mol Syst Biol· June 2021

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Perspective: Linkage Maps, Communities of Geneticists, and Genome Databases.
David Botstein

Genetics· October 2020

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A tps1Δ persister-like state in Saccharomyces cerevisiae is regulated by MKT1.
Patrick A Gibney, Anqi Chen, Ariel Schieler, Jonathan C Chen, Yifan Xu, David Botstein

PLoS One· September 2020

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Fully Phased Sequence of a Diploid Human Genome Determined from the DNA of a Single Individual.
Llya Soifer, Nicole L Fong, Nelda Yi, Andrea T Ireland, Irene Lam, David Botstein

G3 (Bethesda)· September 2020

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Simultaneous Profiling of DNA Accessibility and Gene Expression Dynamics with ATAC-Seq and RNA-Seq.
David G Hendrickson, Ilya Soifer, Bernd J Wranik, David Botstein, R Scott McIsaac

Methods Mol Biol· March 2019

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Minor Isozymes Tailor Yeast Metabolism to Carbon Availability.
Patrick H Bradley, Patrick A Gibney, David Botstein, Olga G Troyanskaya, Joshua D Rabinowitz

mSystems· February 2019

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Discovery and Functional Characterization of a Yeast Sugar Alcohol Phosphatase.
Yi-Fan Xu, Wenyun Lu, Jonathan C Chen, Sarah A Johnson, Patrick A Gibney, David Botstein

ACS Chem Biol· October 2018

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The future of humans as model organisms.
Garret FitzGerald, David Botstein, Robert Califf, Rory Collins, Keith Peters

Science· August 2018

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Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast.
Patrick A Gibney, Ariel Schieler, Jonathan C Chen, Jessie M Bacha-Hummel, Maxim Botstein, David Botstein

Mol Biol Cell· April 2018

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Systems-level analysis of mechanisms regulating yeast metabolic flux.
Sean R Hackett, Vito R T Zanotelli, Wenxin Xu, Jonathan Goya, Junyoung O Park, David Botstein

Science· October 2016

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Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells.
Henrik D Møller, Rasmus K Bojsen, Chris Tachibana, Lance Parsons, David Botstein

J Vis Exp· April 2016

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Analysis of Polygenic Mutants Suggests a Role for Mediator in Regulating Transcriptional Activation Distance in Saccharomyces cerevisiae.
Caitlin T Reavey, Mark J Hickman, Krista C Dobi, David Botstein, Fred Winston

Genetics· October 2015

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Extrachromosomal circular DNA is common in yeast.
Henrik D Møller, Lance Parsons, Tue S Jørgensen, David Botstein, Birgitte Regenberg

Proc Natl Acad Sci U S A· June 2015

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Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter.
Patrick A Gibney, Ariel Schieler, Jonathan C Chen, Joshua D Rabinowitz, David Botstein

Proc Natl Acad Sci U S A· May 2015

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Lasker∼Koshland to genetics pioneer.
David Botstein

Cell· September 2014

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Synthetic biology tools for programming gene expression without nutritional perturbations in Saccharomyces cerevisiae.
R Scott McIsaac, Patrick A Gibney, Sunil S Chandran, Kirsten R Benjamin, David Botstein

Nucleic Acids Res· April 2014

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Yeast metabolic and signaling genes are required for heat-shock survival and have little overlap with the heat-induced genes.
Patrick A Gibney, Charles Lu, Amy A Caudy, David C Hess, David Botstein

Proc Natl Acad Sci U S A· November 2013

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Rapid synthesis and screening of chemically activated transcription factors with GFP-based reporters.
R Scott McIsaac, Benjamin L Oakes, David Botstein, Marcus B Noyes

J Vis Exp· November 2013

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A new system for comparative functional genomics of Saccharomyces yeasts.
Amy A Caudy, Yuanfang Guan, Yue Jia, Christina Hansen, Chris DeSevo, David Botstein

Genetics· September 2013

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Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations.
Gregory I Lang, Daniel P Rice, Mark J Hickman, Erica Sodergren, George M Weinstock, David Botstein

Nature· August 2013

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