Publications by authors named "David C Linch"

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Early rituximab monotherapy versus watchful waiting for advanced stage, asymptomatic, low tumour burden follicular lymphoma: long-term results of a randomised, phase 3 trial.
Michael Northend, William Wilson, Kushani Ediriwickrema, Laura Clifton-Hadley, Wendi Qian, David C Linch

Lancet Haematol· May 2025

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Quality of life in advanced-stage, asymptomatic, non-bulky follicular lymphoma treated with rituximab shows significant improvement compared with watchful-waiting.
Maria A V Marzolini, Wendi Qian, Laura Clifton-Hadley, Pip Patrick, June Warden, David C Linch

Br J Haematol· March 2025

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Genomic characterization of AML with aberrations of chromosome 7: a multinational cohort of 519 patients.
Adriane Halik, Marlon Tilgner, Patricia Silva, Natalia Estrada, Robert Altwasser, David C Linch

J Hematol Oncol· August 2024

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Dual targeting of CD19 and CD22 with bicistronic CAR-T cells in patients with relapsed/refractory large B-cell lymphoma.
Claire Roddie, Lazaros J Lekakis, Maria A V Marzolini, Aravind Ramakrishnan, Yiyun Zhang, David C Linch

Blood· May 2023

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Therapy for isocitrate dehydrogenase 2 (IDH2) -mutant acute myeloid leukaemia.
David C Linch, Robert K Hills, Alan K Burnett, Nigel Russell, Rosemary E Gale

Br J Haematol· March 2022

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Durable Responses and Low Toxicity After Fast Off-Rate CD19 Chimeric Antigen Receptor-T Therapy in Adults With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia.
Claire Roddie, Juliana Dias, Maeve A O'Reilly, Mahnaz Abbasian, Amaia Cadinanos-Garai, David C Linch

J Clin Oncol· October 2021

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Additional impact of mutational genotype on prognostic determination in resistant and relapsed acute myeloid leukaemia.
David C Linch, Robert K Hills, Amanda Gilkes, Alan K Burnett, Nigel Russell

Leuk Res· September 2021

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Favourable outcomes for high-risk Burkitt lymphoma patients (IPI 3-5) treated with rituximab plus CODOX-M/IVAC: Results of a phase 2 UK NCRI trial.
Elizabeth H Phillips, Catherine Burton, Amy A Kirkwood, Sharon Barrans, Anthony Lawrie, David C Linch

EJHaem· July 2020

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-Deficient T-cell Acute Lymphoblastic Leukemia Is Sensitized to CHK1 Inhibition through Enhanced Replication Stress.
Theresa E León, Tanya Rapoz-D'Silva, Cosetta Bertoli, Sunniyat Rahman, Michael Magnussen, David C Linch

Cancer Discov· July 2020

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The clinical impact of mutant DNMT3A R882 variant allele frequency in acute myeloid leukaemia.
David C Linch, Robert K Hills, Alan K Burnett, Rosemary E Gale

Br J Haematol· May 2020

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Analysis of the clinical impact of NPM1 mutant allele burden in a large cohort of younger adult patients with acute myeloid leukaemia.
David C Linch, Robert K Hills, Alan K Burnett, Nigel Russell, Rosemary E Gale

Br J Haematol· March 2020

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In trans early mosaic mutational escape and novel phenotypic features of germline SAMD9 mutation.
Catherine Hockings, Satyen Gohil, Robin Dowse, Yvette Hoade, Marc R Mansour, David C Linch

Br J Haematol· February 2020

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Allo-HSCT in transplant-naïve patients with Hodgkin lymphoma: a single-arm, multicenter study.
Emma Das-Gupta, Kirsty J Thomson, Adrian J C Bloor, Andrew D Clark, Stephen Mackinnon, David C Linch

Blood Adv· December 2019

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Genomic landscape and clonal evolution of acute myeloid leukemia with t(8;21): an international study on 331 patients.
Friederike Christen, Kaja Hoyer, Kenichi Yoshida, Hsin-An Hou, Nils Waldhueter, David C Linch

Blood· March 2019

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Prognostic impact of the absence of biallelic deletion at the locus for pediatric patients with T-cell acute lymphoblastic leukemia treated on the Medical Research Council UK Acute Lymphoblastic Leukemia 2003 trial.
Nadine Farah, Amy A Kirkwood, Sunniyat Rahman, Theresa Leon, Sarah Jenkinson, David C Linch

Haematologica· July 2018

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Use of split peripheral blood stem cell harvests in myeloma identifies functional preservation of progenitor cells cryopreserved for several years and demonstrates no functional damage to the bone marrow microenvironment.
Michael John Watts, Stuart James Ings, Jude Dorman, Neil Rabin, David Christopher Linch

Bone Marrow Transplant· June 2018

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Immunophenotypic analysis of cell cycle status in acute myeloid leukaemia: relationship to cytogenetics, genotype and clinical outcome.
Rob S Sellar, Rosemary E Gale, Asim Khwaja, Maciej Garbowski, Marco Loddo, David C Linch

Br J Haematol· May 2018

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Variable outcome and methylation status according to mutant type in double-mutated acute myeloid leukemia patients and the possible implications for treatment.
Dima El-Sharkawi, Duncan Sproul, Christopher G Allen, Andrew Feber, Melissa Wright, David C Linch

Haematologica· January 2018

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No evidence that CD33 splicing SNP impacts the response to GO in younger adults with AML treated on UK MRC/NCRI trials.
Rosemary E Gale, Teodora Popa, Melissa Wright, Naeem Khan, Sylvie D Freeman, David C Linch

Blood· January 2018

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Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.
Paul M Maciocia, Patrycja A Wawrzyniecka, Brian Philip, Ida Ricciardelli, Ayse U Akarca, David C Linch

Nat Med· December 2017

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Activation of the oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia.
Sunniyat Rahman, Michael Magnussen, Theresa E León, Nadine Farah, Zhaodong Li, David C Linch

Blood· June 2017

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Next-generation sequencing identifies a novel ELAVL1-TYK2 fusion gene in MOLM-16, an AML cell line highly sensitive to the PIM kinase inhibitor AZD1208.
Adriana E Tron, Erika K Keeton, Minwei Ye, Matias Casas-Selves, Huawei Chen, David C Linch

Leuk Lymphoma· December 2016

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Optimisation and quality control of cell processing for autologous stem cell transplantation.
Michael J Watts, David C Linch

Br J Haematol· December 2016

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Re-evaluation of progenitor thresholds and expectations for haematopoietic recovery based on an analysis of 810 autologous transplants: Implications for quality assurance.
Michael J Watts, Stuart J Ings, Carmen Balsa, Andrew Antonio, Simon Hack, David C Linch

Br J Haematol· November 2016

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Acute myeloid leukaemia.
Asim Khwaja, Magnus Bjorkholm, Rosemary E Gale, Ross L Levine, Craig T Jordan, David C Linch

Nat Rev Dis Primers· March 2016

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