Publications by authors named "Minwei Ye"

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Synthetic chemistry enabling the discovery and development of a series of pyrazoles as HPK1 inhibitors.
Anthony J Metrano, Lucas A Morrill, Gayathri Bommakanti, Robert Casella, Steve Cook, Ye Wu, Minwei Ye

RSC Med Chem· May 2025

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Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor.
Jason D Shields, David Baker, Amber Y S Balazs, Gayathri Bommakanti, Robert Casella, Ye Wu, Minwei Ye

J Med Chem· February 2025

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Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.
Adelphe M Mfuh, Jeffrey A Boerth, Gayathri Bommakanti, Christina Chan, Alex J Chinn, Min-Wei Ye

J Med Chem· January 2024

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Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity.
Jeffrey A Boerth, Alex J Chinn, Marianne Schimpl, Gayathri Bommakanti, Christina Chan, Minwei Ye

ACS Med Chem Lett· December 2023

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Antisense Oligonucleotide Remodels the Suppressive Tumor Microenvironment to Enhance Immune Activation in Combination with Anti-PD-L1.
Theresa A Proia, Maneesh Singh, Richard Woessner, Larissa Carnevalli, Gayathri Bommakanti, Minwei Ye

Clin Cancer Res· December 2020

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Small molecule AZD4635 inhibitor of AR signaling rescues immune cell function including CD103 dendritic cells enhancing anti-tumor immunity.
Alexandra Borodovsky, Christine M Barbon, Yanjun Wang, Minwei Ye, Laura Prickett

J Immunother Cancer· July 2020

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Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells.
Aditi Shastri, Gaurav Choudhary, Margarida Teixeira, Shanisha Gordon-Mitchell, Nandini Ramachandra, B Hilda Ye, Minwei Ye

J Clin Invest· December 2018

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Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.
Neil P Grimster, Erica Anderson, Marat Alimzhanov, Geraldine Bebernitz, Kirsten Bell, Minwei Ye

J Med Chem· June 2018

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Next-generation sequencing identifies a novel ELAVL1-TYK2 fusion gene in MOLM-16, an AML cell line highly sensitive to the PIM kinase inhibitor AZD1208.
Adriana E Tron, Erika K Keeton, Minwei Ye, Matias Casas-Selves, Huawei Chen

Leuk Lymphoma· December 2016

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Identification of azabenzimidazoles as potent JAK1 selective inhibitors.
Melissa M Vasbinder, Marat Alimzhanov, Martin Augustin, Geraldine Bebernitz, Kirsten Bell, Minwei Ye

Bioorg Med Chem Lett· January 2016

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Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors.
Qibin Su, Stephanos Ioannidis, Claudio Chuaqui, Lynsie Almeida, Marat Alimzhanov, Minwei Ye

J Med Chem· January 2014

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Discovery of novel Jak2-Stat pathway inhibitors with extended residence time on target.
Huiping Guan, Michelle L Lamb, Bo Peng, Shan Huang, Nancy Degrace, Syeed Hussain, Minwei Ye

Bioorg Med Chem Lett· May 2013

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Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitors.
Melissa M Vasbinder, Brian Aquila, Martin Augustin, Huawei Chen, Tony Cheung, Minwei Ye

J Med Chem· March 2013

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Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway.
Stephanos Ioannidis, Michelle L Lamb, Tao Wang, Lynsie Almeida, Michael H Block, Minwei Ye

J Med Chem· January 2011

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Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors.
Stephanos Ioannidis, Michelle L Lamb, Audrey M Davies, Lynsie Almeida, Mei Su, Minwei Ye

Bioorg Med Chem Lett· December 2009

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The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors.
Michael Hedvat, Dennis Huszar, Andreas Herrmann, Joseph M Gozgit, Anne Schroeder, Minwei Ye

Cancer Cell· December 2009

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Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2.
Joseph M Gozgit, Geraldine Bebernitz, Pankaj Patil, Minwei Ye, Julie Parmentier

J Biol Chem· November 2008

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Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer.
David A Scott, Brian M Aquila, Geraldine A Bebernitz, Donald J Cook, Les A Dakin, Minwei Ye

Bioorg Med Chem Lett· September 2008

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