Publications by authors named "Tony Cheung"

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Structure-Based Discovery of a Series of Covalent, Orally Bioavailable, and Selective BFL1 Inhibitors.
Adeline Palisse, Tony Cheung, Aileen Blokhuis, Thomas Cogswell, Bruna S Martins

J Med Chem· December 2024

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Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors.
Simon C C Lucas, J Henry Blackwell, Ulf Börjesson, David Hargreaves, Alexander G Milbradt, Tony Cheung

J Med Chem· September 2024

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Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibition.
Valentina Fogal, Filippos Michopoulos, Andrew F Jarnuczak, Ghaith M Hamza, Stephanie Harlfinger, Tony Cheung

Arch Toxicol· August 2024

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Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer.
Ryan Blawski, Bujamin H Vokshi, Xinyu Guo, Srushti Kittane, Mirna Sallaku, Tony Cheung

Cell Rep· May 2024

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Development of a Series of Pyrrolopyridone MAT2A Inhibitors.
Stephen J Atkinson, Sharan K Bagal, Argyrides Argyrou, Sean Askin, Tony Cheung

J Med Chem· March 2024

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Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor.
Iacovos N Michaelides, Gavin W Collie, Ulf Börjesson, Christina Vasalou, Omar Alkhatib, Tony Cheung

J Med Chem· July 2023

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Fragment-Based Design of a Potent MAT2a Inhibitor and Evaluation in an MTAP Null Xenograft Model.
Claudia De Fusco, Marianne Schimpl, Ulf Börjesson, Tony Cheung, Iain Collie

J Med Chem· May 2021

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Rapid Identification of Novel Allosteric PRC2 Inhibitors.
Jon A Read, Jonathan Tart, Philip B Rawlins, Clare Gregson, Karen Jones, Tony Cheung

ACS Chem Biol· October 2019

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Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors.
Gavin W Collie, Cheryl M Koh, Daniel J O'Neill, Christopher J Stubbs, Puneet Khurana, Tony Cheung

ACS Med Chem Lett· September 2019

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Programmed Cell Death Receptor (PD-1) Ligand (PD-L1) expression in Philadelphia chromosome-negative myeloproliferative neoplasms.
Jen-Chin Wang, Chi Chen, Ajay Kundra, Sreenath Kodali, Anita Pandey, Tony Cheung

Leuk Res· April 2019

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Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer.
Zebin Wang, Shaun E Grosskurth, Tony Cheung, Philip Petteruti, Jingwen Zhang

Cancer Res· December 2018

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Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.
William McCoull, Tony Cheung, Erica Anderson, Peter Barton, Jonathan Burgess

ACS Chem Biol· November 2018

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Prospective randomized controlled trial comparing partially absorbable lightweight mesh and multifilament polyester anatomical mesh in laparoscopic inguinal hernia repair.
John Cc Wong, George Pc Yang, Tony Pp Cheung, Michael Kw Li

Asian J Endosc Surg· May 2018

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AZ304, a novel dual BRAF inhibitor, exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status.
Rui Ma, Ling Xu, Xiujuan Qu, Xiaofang Che, Ye Zhang, Tony Cheung

Br J Cancer· May 2018

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Correction to Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
William McCoull, Roman D Abrams, Erica Anderson, Kevin Blades, Peter Barton, Tony Cheung

J Med Chem· July 2017

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Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
William McCoull, Roman D Abrams, Erica Anderson, Kevin Blades, Peter Barton, Tony Cheung

J Med Chem· May 2017

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Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors.
Scott D Cowen, Daniel Russell, Leslie A Dakin, Huawei Chen, Nicholas A Larsen, Tony Cheung

J Med Chem· December 2016

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AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies.
Garrett W Rhyasen, Maureen M Hattersley, Yi Yao, Austin Dulak, Wenxian Wang, Tony Cheung

Mol Cancer Ther· November 2016

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Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitors.
Melissa M Vasbinder, Brian Aquila, Martin Augustin, Huawei Chen, Tony Cheung

J Med Chem· March 2013

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Structural basis of substrate methylation and inhibition of SMYD2.
Andrew D Ferguson, Nicholas A Larsen, Tina Howard, Hannah Pollard, Isabelle Green, Tony Cheung

Structure· September 2011

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Biochemical characterization of human SET and MYND domain-containing protein 2 methyltransferase.
Jiaquan Wu, Tony Cheung, Christie Grande, Andrew D Ferguson, Xiahui Zhu

Biochemistry· July 2011

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Aplysamine 6, an alkaloidal inhibitor of Isoprenylcysteine carboxyl methyltransferase from the sponge Pseudoceratina sp.
Malcolm S Buchanan, Anthony R Carroll, Gregory A Fechner, Anthony Boyle, Moana Simpson, Tony Cheung

J Nat Prod· June 2008

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Small-molecule inhibitors of the cancer target, isoprenylcysteine carboxyl methyltransferase, from Hovea parvicalyx.
Malcolm S Buchanan, Anthony R Carroll, Gregory A Fechner, Anthony Boyle, Moana Simpson, Tony Cheung

Phytochemistry· June 2008

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BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Susan Magdaleno, Patricia Jensen, Craig L Brumwell, Anna Seal, Karen Lehman, Tony Cheung

PLoS Biol· April 2006

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AIDS-related cancer in the era of highly active antiretroviral therapy (HAART): a model of the interplay of the immune system, virus, and cancer. "On the offensive--the Trojan Horse is being destroyed"--Part B: Malignant lymphoma.
Tony W Cheung

Cancer Invest· December 2004

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