Publications by authors named "David C Lowe"

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Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction.
Elizabeth England, D Gareth Rees, Ian Christopher Scott, Sara Carmen, Denice T Y Chan, David C Lowe

Sci Rep· June 2023

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An in vivo platform to select and evolve aggregation-resistant proteins.
Jessica S Ebo, Janet C Saunders, Paul W A Devine, Alice M Gordon, Amy S Warwick, David C Lowe

Nat Commun· April 2020

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Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1.
Katherine A Vousden, Tomas Lundqvist, Bojana Popovic, Brian Naiman, Alan M Carruthers, David C Lowe

Sci Rep· February 2019

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Investigating the Structural Compaction of Biomolecules Upon Transition to the Gas-Phase Using ESI-TWIMS-MS.
Paul W A Devine, Henry C Fisher, Antonio N Calabrese, Fiona Whelan, Daniel R Higazi, David C Lowe

J Am Soc Mass Spectrom· September 2017

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Inducing protein aggregation by extensional flow.
John Dobson, Amit Kumar, Leon F Willis, Roman Tuma, Daniel R Higazi, David C Lowe

Proc Natl Acad Sci U S A· May 2017

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A comparison of the ability of the human IgG1 allotypes G1m3 and G1m1,17 to stimulate T-cell responses from allotype matched and mismatched donors.
Carl I Webster, Christine J Bryson, Edward A Cloake, Tim D Jones, Mark J Austin, David C Lowe

MAbs· December 2016

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Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo.
Claire L Dobson, Paul W A Devine, Jonathan J Phillips, Daniel R Higazi, Christopher Lloyd, David C Lowe

Sci Rep· December 2016

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The INNs and outs of antibody nonproprietary names.
Tim D Jones, Paul J Carter, Andreas Plückthun, Max Vásquez, Robert G E Holgate, David C Lowe

MAbs· September 2016

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Rheumatology: a force for change in monoclonal antibodies.
David C Lowe, Tristan J Vaughan

Curr Pharm Des· May 2016

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Global and Local Conformation of Human IgG Antibody Variants Rationalizes Loss of Thermodynamic Stability.
Matthew J Edgeworth, Jonathan J Phillips, David C Lowe, Alistair D Kippen, Daniel R Higazi

Angew Chem Int Ed Engl· December 2015

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Affinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1.
Julie A Douthwaite, Sudharsan Sridharan, Catherine Huntington, Jayne Hammersley, Rose Marwood, David C Lowe

MAbs· September 2015

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Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation.
E Suzanne Cohen, Ian C Scott, Jayesh B Majithiya, Laura Rapley, Benjamin P Kemp, David C Lowe

Nat Commun· September 2015

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Monovalent IgG4 molecules: immunoglobulin Fc mutations that result in a monomeric structure.
Ian C Wilkinson, Susan B Fowler, Leeann Machiesky, Kenneth Miller, David B Hayes, David C Lowe

MAbs· April 2015

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Antibody VH and VL recombination using phage and ribosome display technologies reveals distinct structural routes to affinity improvements with VH-VL interface residues providing important structural diversity.
Maria A T Groves, Lily Amanuel, Jamie I Campbell, D Gareth Rees, Sudharsan Sridharan, David C Lowe

MAbs· October 2014

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Current approaches to fine mapping of antigen-antibody interactions.
W Mark Abbott, Melissa M Damschroder, David C Lowe

Immunology· August 2014

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Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell-mediated antibody-dependent cellular cytotoxicity.
Dominika Rudnicka, Anna Oszmiana, Donna K Finch, Ian Strickland, Darren J Schofield, David C Lowe

Blood· June 2013

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Engineering approaches to develop the next generation of antibodies to respiratory targets.
Katherine A Vousden, Deborah L Clarke, David C Lowe

Inflamm Allergy Drug Targets· April 2013

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Development of a homogeneous high-throughput screening assay for biological inhibitors of human rhinovirus infection.
Philip Newton, Desmond O'Shea, Edward Wells, Kerry Moakes, Rebecca Dunmore, David C Lowe

J Biomol Screen· March 2013

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Whole-molecule antibody engineering: generation of a high-affinity anti-IL-6 antibody with extended pharmacokinetics.
Donna K Finch, Matthew A Sleeman, Jacques Moisan, Franco Ferraro, Sara Botterell, David C Lowe

J Mol Biol· August 2011

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Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an α-helix in VH CDR3 as key component of paratope.
David C Lowe, Stefan Gerhardt, Alison Ward, David Hargreaves, Malcolm Anderson

J Mol Biol· February 2011

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Global change: a green source of surprise.
David C Lowe

Nature· January 2006

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Short-term variations in the oxidizing power of the atmosphere.
Martin R Manning, David C Lowe, Rowena C Moss, Gregory E Bodeker, William Allan

Nature· August 2005

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