Publications by authors named "David Clynes"

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Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers.
Tomas Goncalves, Siobhan Cunniffe, Tiffany S Ma, Natalie Mattis, Andrew W Rose, David Clynes

Nucleic Acids Res· February 2025

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Phosphorylation of 'SDT-like' motifs in ATRX mediates its interaction with the MRN complex and is important for ALT pathway suppression.
Tomas Goncalves, Harshangda Bhatnagar, Siobhan Cunniffe, Richard J Gibbons, Anna M Rose, David Clynes

Open Biol· December 2024

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Induction of the alternative lengthening of telomeres pathway by trapping of proteins on DNA.
Anna M Rose, Tomas Goncalves, Siobhan Cunniffe, Helene E B Geiller, Thomas Kent, David Clynes

Nucleic Acids Res· July 2023

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Loss of FAM111B protease mutated in hereditary fibrosing poikiloderma negatively regulates telomere length.
Maciej Kliszczak, Daniela Moralli, Julia D Jankowska, Paulina Bryjka, Lamia Subha Meem, David Clynes

Front Cell Dev Biol· June 2023

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Alternative Lengthening of Telomeres: Lessons to Be Learned from Telomeric DNA Double-Strand Break Repair.
Thomas Kent, David Clynes

Genes (Basel)· October 2021

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Alternative Lengthening of Telomeres in Pediatric Cancer: Mechanisms to Therapies.
Thomas Kent, Deanne Gracias, Samuel Shepherd, David Clynes

Front Oncol· January 2020

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The chromatin remodelling factor ATRX suppresses R-loops in transcribed telomeric repeats.
Diu Tt Nguyen, Hsiao Phin J Voon, Barbara Xella, Caroline Scott, David Clynes

EMBO Rep· June 2017

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Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX.
David Clynes, Clare Jelinska, Barbara Xella, Helena Ayyub, Caroline Scott

Nat Commun· July 2015

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ATRX dysfunction induces replication defects in primary mouse cells.
David Clynes, Clare Jelinska, Barbara Xella, Helena Ayyub, Stephen Taylor

PLoS One· November 2014

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JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response.
Edwin Chen, Jong Sook Ahn, Charlie E Massie, David Clynes, Anna L Godfrey

Proc Natl Acad Sci U S A· October 2014

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Lysine acetylation controls local protein conformation by influencing proline isomerization.
Françoise S Howe, Ivan Boubriak, Matthew J Sale, Anitha Nair, David Clynes

Mol Cell· September 2014

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The chromatin remodeller ATRX: a repeat offender in human disease.
David Clynes, Douglas R Higgs, Richard J Gibbons

Trends Biochem Sci· September 2013

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ATRX and the replication of structured DNA.
David Clynes, Richard J Gibbons

Curr Opin Genet Dev· June 2013

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Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin.
Sebastian Eustermann, Ji-Chun Yang, Martin J Law, Rachel Amos, Lynda M Chapman, David Clynes

Nat Struct Mol Biol· June 2011

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Nucleosome remodeling and transcriptional repression are distinct functions of Isw1 in Saccharomyces cerevisiae.
Marina Pinskaya, Anitha Nair, David Clynes, Antonin Morillon, Jane Mellor

Mol Cell Biol· May 2009

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14-3-3 interaction with histone H3 involves a dual modification pattern of phosphoacetylation.
Wendy Walter, David Clynes, Yong Tang, Ronen Marmorstein, Jane Mellor

Mol Cell Biol· April 2008

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A glimpse into the epigenetic landscape of gene regulation.
Jane Mellor, Peter Dudek, David Clynes

Curr Opin Genet Dev· April 2008

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Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3.
Neil Macdonald, Julie P I Welburn, Martin E M Noble, Anhco Nguyen, Michael B Yaffe, David Clynes

Mol Cell· October 2005

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