Publications by authors named "David D Holcomb"

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Therapeutic implications of synonymous gene recoding: insights into mechanisms controlling protein biogenesis and activity.
Brian C Lin, Katarzyna I Jankowska, Upendra K Katneni, Randilu Amarasinghe, Nigam Padhiar, David D Holcomb

Protein Cell· October 2025

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Synonymous ADAMTS13 variants impact molecular characteristics and contribute to variability in active protein abundance.
Katarzyna I Jankowska, Douglas Meyer, David D Holcomb, Jacob Kames, Nobuko Hamasaki-Katagiri

Blood Adv· September 2022

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Protocol to identify host-viral protein interactions between coagulation-related proteins and their genetic variants with SARS-CoV-2 proteins.
David D Holcomb, Katarzyna I Jankowska, Nancy Hernandez, Kyle Laurie, Jacob Kames

STAR Protoc· September 2022

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Structural, functional, and immunogenicity implications of F9 gene recoding.
Upendra K Katneni, Aikaterini Alexaki, Ryan C Hunt, Nobuko Hamasaki-Katagiri, Gaya K Hettiarachchi, David D Holcomb

Blood Adv· July 2022

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A conserved epitope III on hepatitis C virus E2 protein has alternate conformations facilitating cell binding or virus neutralization.
Lu Deng, Nancy Hernandez, Lilin Zhong, David D Holcomb, Hailing Yan

Proc Natl Acad Sci U S A· July 2021

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Ribosome profiling of HEK293T cells overexpressing codon optimized coagulation factor IX.
Aikaterini Alexaki, Jacob Kames, Gaya K Hettiarachchi, John C Athey, Upendra K Katneni, David D Holcomb

F1000Res· February 2021

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In silico features of ADAMTS13 contributing to plasmatic ADAMTS13 levels in neonates with congenital heart disease.
Upendra K Katneni, David D Holcomb, Nancy E Hernandez, Nobuko Hamasaki-Katagiri, Ryan C Hunt

Thromb Res· September 2020

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Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design.
Jacob Kames, David D Holcomb, Ofer Kimchi, Michael DiCuccio, Nobuko Hamasaki-Katagiri

Sci Rep· September 2020

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TissueCoCoPUTs: Novel Human Tissue-Specific Codon and Codon-Pair Usage Tables Based on Differential Tissue Gene Expression.
Jacob Kames, Aikaterini Alexaki, David D Holcomb, Luis V Santana-Quintero, John C Athey

J Mol Biol· May 2020

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Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design.
Jacob Kames, David D Holcomb, Ofer Kimchi, Michael DiCuccio, Nobuko Hamasaki-Katagiri

bioRxiv· March 2020

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Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies.
Aikaterini Alexaki, Gaya K Hettiarachchi, John C Athey, Upendra K Katneni, Vijaya Simhadri, David D Holcomb

Sci Rep· October 2019

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The Kazusa codon usage database, CoCoPUTs, and the value of up-to-date codon usage statistics.
David D Holcomb, Aikaterini Alexaki, Upendra Katneni, Chava Kimchi-Sarfaty

Infect Genet Evol· September 2019

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Codon and Codon-Pair Usage Tables (CoCoPUTs): Facilitating Genetic Variation Analyses and Recombinant Gene Design.
Aikaterini Alexaki, Jacob Kames, David D Holcomb, John Athey, Luis V Santana-Quintero

J Mol Biol· June 2019

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