Publications by authors named "David De Semir"

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The GR-LEDGF/p75-HSP27 Axis Contributes to Cross-Resistance Between Enzalutamide and Docetaxel in Prostate Cancer.
Pedro T Ochoa, Evelyn S Sanchez-Hernandez, Alfonso M Duran, Kai Wen Cheng, Joel Philip, David de Semir

Cells· October 2025

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Combinatorial therapy regimens targeting preclinical models of melanoma resistant to immune checkpoint blockade.
Imran Khan, Aida Rodriguez-Brotons, Anukana Bhattacharjee, Vladimir Bezrookove, Altaf Dar, David De Semir

J Clin Invest· September 2025

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Prognostic Significance and Emerging Predictive Potential of Interleukin-1β Expression in Oncogene-Driven NSCLC.
Mengni Guo, Won Jin Jeon, Bowon Joung, Derek Tai, Alexander Gavralidis, David de Semir

Cancers (Basel)· September 2025

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Phase II Study of Niraparib in Patients With Advanced Melanoma With Homologous Recombination Pathway Gene Mutations.
Kevin B Kim, Pierre-Yves Desprez, David de Semir, Rinette W L Woo, Anima Sharma

JCO Precis Oncol· May 2025

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Targeting DNA helicase CMG complex and NFκB2-driven drug-resistant transcriptional axis to effectively treat KRAS-mutated pancreatic cancer.
Jeffrey Xiao, Joshua Kim, Brandon Park, David J Baylink, Cedric Kwon, David De Semir

Exp Hematol Oncol· May 2025

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Inhibition of Mitochondrial-Associated Protein MAGMAS Resensitizes Chemoresistant Prostate Cancer Cells to Docetaxel.
Alfonso M Durán, Kristen Whitley, Krystal Santiago, Christian Yoo, Giancarlo Valdez, David de Semir

Cancers (Basel)· April 2025

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Pan-Cancer Pharmacogenomic Analysis of Patient-Derived Tumor Cells Using Clinically Relevant Drug Exposures.
Stephen H Chang, Ryan J Ice, Michelle Chen, Maxim Sidorov, Rinette W L Woo, David de Semir

Mol Cancer Ther· September 2023

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Pitfalls and Rewards of Setting Up a Liquid Biopsy Approach for the Detection of Driver Mutations in Circulating Tumor DNAs: Our Institutional Experience.
Michelle Chen, Damon Jian, Maxim Sidorov, Rinette W L Woo, Angela Kim, David de Semir

J Pers Med· November 2022

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Prevalence of Homologous Recombination Pathway Gene Mutations in Melanoma: Rationale for a New Targeted Therapeutic Approach.
Kevin B Kim, Liliana Soroceanu, David de Semir, Sherri Z Millis, Jeffrey Ross

J Invest Dermatol· August 2021

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Nuclear Receptor Coactivator NCOA3 Regulates UV Radiation-Induced DNA Damage and Melanoma Susceptibility.
David de Semir, Vladimir Bezrookove, Mehdi Nosrati, Altaf A Dar, James R Miller

Cancer Res· June 2021

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Dinaciclib, a cyclin-dependent kinase inhibitor, suppresses cholangiocarcinoma growth by targeting CDK2/5/9.
Hera Saqub, Hannah Proetsch-Gugerbauer, Vladimir Bezrookove, Mehdi Nosrati, Edith M Vaquero, David de Semir

Sci Rep· October 2020

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PHIP drives glioblastoma motility and invasion by regulating the focal adhesion complex.
David de Semir, Vladimir Bezrookove, Mehdi Nosrati, Kara R Scanlon, Eric Singer

Proc Natl Acad Sci U S A· April 2020

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Drug responses are conserved across patient-derived xenograft models of melanoma leading to identification of novel drug combination therapies.
Ryan J Ice, Michelle Chen, Max Sidorov, Tam Le Ho, Rinette W L Woo, David de Semir

Br J Cancer· March 2020

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Novel tumor suppressor role of miRNA-876 in cholangiocarcinoma.
Sarah Ursu, Shahana Majid, Caroline Garger, David de Semir, Vladimir Bezrookove

Oncogenesis· August 2019

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PHIPing along: Evolution of PHIP as a cancer biomarker and a target for therapy.
Mohammed Kashani-Sabet, Vladimir Bezrookove, David de Semir

Oncotarget· November 2018

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Role of Elevated Copy Number as a Prognostic and Progression Marker for Cutaneous Melanoma.
Vladimir Bezrookove, Mehdi Nosrati, James R Miller, David De Semir, Altaf A Dar

Clin Cancer Res· September 2018

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PHIP as a therapeutic target for driver-negative subtypes of melanoma, breast, and lung cancer.
David de Semir, Vladimir Bezrookove, Mehdi Nosrati, Altaf A Dar, Clayton Wu

Proc Natl Acad Sci U S A· June 2018

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BPTF transduces MITF-driven prosurvival signals in melanoma cells.
Altaf A Dar, Shahana Majid, Vladimir Bezrookove, Binh Phan, Sarah Ursu, David De Semir

Proc Natl Acad Sci U S A· May 2016

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Tumor suppressor role of microRNA-1296 in triple-negative breast cancer.
Binh Phan, Shahana Majid, Sarah Ursu, David de Semir, Mehdi Nosrati

Oncotarget· April 2016

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The role of BPTF in melanoma progression and in response to BRAF-targeted therapy.
Altaf A Dar, Mehdi Nosrati, Vladimir Bezrookove, David de Semir, Shahana Majid

J Natl Cancer Inst· February 2015

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Antitumor activity of miR-1280 in melanoma by regulation of Src.
Vera Sun, Wen B Zhou, Mehdi Nosrati, Shahana Majid, Suresh Thummala, David de Semir

Mol Ther· January 2015

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Prognostic impact of PHIP copy number in melanoma: linkage to ulceration.
Vladimir Bezrookove, David De Semir, Mehdi Nosrati, Schuyler Tong, Clayton Wu

J Invest Dermatol· March 2014

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The role of miR-18b in MDM2-p53 pathway signaling and melanoma progression.
Altaf A Dar, Shahana Majid, Claudia Rittsteuer, David de Semir, Vladimir Bezrookove

J Natl Cancer Inst· March 2013

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Pleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis.
David De Semir, Mehdi Nosrati, Vladimir Bezrookove, Altaf A Dar, Scot Federman

Proc Natl Acad Sci U S A· May 2012

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miRNA-205 suppresses melanoma cell proliferation and induces senescence via regulation of E2F1 protein.
Altaf A Dar, Shahana Majid, David de Semir, Mehdi Nosrati, Vladimir Bezrookove

J Biol Chem· May 2011

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