Publications by authors named "David F Fischer"

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Drug repurposing screen for the rare disease ataxia-telangiectasia.
Namrata Jayanth, Gurvan Mahé, Matthew Campbell, Mike Lipkin, Shushant Jain, David F Fischer

SLAS Discov· January 2025

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Physiological and behavioural implications of the portosystemic shunt in C57Bl/6J mice.
Kimmo K Lehtimäki, Jussi Rytkönen, Raimo Pussinen, Artem Shatillo, Timo Bragge, David F Fischer

J Physiol· October 2024

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RNA-based drug discovery for spinal muscular atrophy: a story of small molecules and antisense oligonucleotides.
Blanca Torroba, Natsuko Macabuag, Elisabeth M Haisma, Amy O'Neill, Maria E Herva, David F Fischer

Expert Opin Drug Discov· February 2023

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Development of mAb-based polyglutamine-dependent and polyglutamine length-independent huntingtin quantification assays with cross-site validation.
David F Fischer, Sipke Dijkstra, Kimberly Lo, Johnny Suijker, Ana C P Correia

PLoS One· April 2022

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Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models.
Leticia Toledo-Sherman, Perla Breccia, Roger Cachope, Jennifer R Bate, Ivan Angulo-Herrera, David F Fischer

J Med Chem· March 2019

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Identification of regulators of the myofibroblast phenotype of primary dermal fibroblasts from early diffuse systemic sclerosis patients.
Loubna Chadli, Britt Sotthewes, Kejie Li, Stefan N Andersen, Ellen Cahir-McFarland, David F Fischer

Sci Rep· March 2019

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Assessment of p.Phe508del-CFTR functional restoration in pediatric primary cystic fibrosis airway epithelial cells.
Erika N Sutanto, Amelia Scaffidi, Luke W Garratt, Kevin Looi, Clara J Foo, David F Fischer

PLoS One· February 2018

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Quantification of huntingtin protein species in Huntington's disease patient leukocytes using optimised electrochemiluminescence immunoassays.
Davina J Hensman Moss, Nicola Robertson, Ruth Farmer, Rachael I Scahill, Salman Haider, David F Fischer

PLoS One· January 2018

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A small molecule mitigates hearing loss in a mouse model of Usher syndrome III.
Kumar N Alagramam, Suhasini R Gopal, Ruishuang Geng, Daniel H-C Chen, Ina Nemet, David F Fischer

Nat Chem Biol· June 2016

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Quantification assays for total and polyglutamine-expanded huntingtin proteins.
Douglas Macdonald, Michela A Tessari, Ivette Boogaard, Melanie Smith, Kristiina Pulli, David F Fischer

PLoS One· January 2015

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A monoclonal antibody TrkB receptor agonist as a potential therapeutic for Huntington's disease.
Daniel Todd, Ian Gowers, Simon J Dowler, Michael D Wall, George McAllister, David F Fischer

PLoS One· December 2014

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Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.
Xiao-Hong Lu, Virginia B Mattis, Nan Wang, Ismael Al-Ramahi, Nick van den Berg, David F Fischer

Sci Transl Med· December 2014

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Mutant ubiquitin decreases amyloid β plaque formation in a transgenic mouse model of Alzheimer's disease.
Paula van Tijn, Frank J A Dennissen, Romina J G Gentier, Barbara Hobo, Denise Hermes, David F Fischer

Neurochem Int· October 2012

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Alzheimer-associated mutant ubiquitin impairs spatial reference memory.
Paula van Tijn, Barbara Hobo, Marian C Verhage, Melly S Oitzl, Fred W van Leeuwen, David F Fischer

Physiol Behav· February 2011

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Low levels of mutant ubiquitin are degraded by the proteasome in vivo.
Paula van Tijn, Marian C Verhage, Barbara Hobo, Fred W van Leeuwen, David F Fischer

J Neurosci Res· August 2010

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Histological and functional benefit following transplantation of motor neuron progenitors to the injured rat spinal cord.
Sharyn L Rossi, Gabriel Nistor, Tanya Wyatt, Hong Zhen Yin, Aleksandra J Poole, David F Fischer

PLoS One· July 2010

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Modest proteasomal inhibition by aberrant ubiquitin exacerbates aggregate formation in a Huntington disease mouse model.
Remko de Pril, Barbara Hobo, Paula van Tijn, Raymund A C Roos, Fred W van Leeuwen, David F Fischer

Mol Cell Neurosci· March 2010

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Intermediate filament transcription in astrocytes is repressed by proteasome inhibition.
Jinte Middeldorp, Willem Kamphuis, Jacqueline A Sluijs, Dalila Achoui, Cathalijn H C Leenaars, David F Fischer

FASEB J· August 2009

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Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin.
David F Fischer, Renske van Dijk, Paula van Tijn, Barbara Hobo, Marian C Verhage

Neurobiol Aging· June 2009

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The alpha7 nicotinic acetylcholine receptor on fibroblast-like synoviocytes and in synovial tissue from rheumatoid arthritis patients: a possible role for a key neurotransmitter in synovial inflammation.
Marjolein A van Maanen, Susanne P Stoof, Esmerij P van der Zanden, Wouter J de Jonge, Richard A Janssen, David F Fischer

Arthritis Rheum· May 2009

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The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons.
Amantha Thathiah, Kurt Spittaels, Marcel Hoffmann, Mik Staes, Adrian Cohen, David F Fischer

Science· February 2009

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The neuronal ubiquitin-proteasome system: murine models and their neurological phenotype.
Paula van Tijn, Elly M Hol, Fred W van Leeuwen, David F Fischer

Prog Neurobiol· June 2008

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An estrogenic effect of 5alpha-androstane-3beta, 17beta-diol on the behavioral response to stress and on CRH regulation.
Qian Huang, Hong Zhu, David F Fischer, Jiang-Ning Zhou

Neuropharmacology· June 2008

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Proteasome subunit proteins and neuropathology in tauopathies and synucleinopathies: Consequences for proteomic analyses.
Mohamed Zouambia, David F Fischer, Barbara Hobo, Rob A I De Vos, Elly M Hol

Proteomics· March 2008

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A promoter polymorphism in the monoamine oxidase A gene is associated with the pineal MAOA activity in Alzheimer's disease patients.
Ying-Hui Wu, David F Fischer, Dick F Swaab

Brain Res· September 2007

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