Publications by authors named "David Frick"

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Hepatitis C virus NS3 helicase contributes to (-) strand RNA synthesis.
Philipp Ralfs, Stéphane Bressanelli, Lina M Günter, Alexander Gabel, Paul Rothhaar, David N Frick

Nat Commun· August 2025

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Synthesis of Molecular Organo-f-Element-Polyphosphides with Nonclassical Divalent Lanthanide Precursors.
David Frick, Elena Pross, Ralf Köppe, Peter W Roesky

Angew Chem Int Ed Engl· July 2025

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Optimization of a high throughput screening platform to identify inhibitors of asymmetric diadenosine polyphosphatases.
David N Frick, Mujidat Shittu, Chase R Bock, Zoe P Wardle, Abdullah A Rauf

Anal Biochem· February 2025

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Analogs of NIH Molecular Probe ML283 Are Potent SARS-CoV-2 Helicase Inhibitors.
David N Frick, Robert V Bavisotto, Nicholas C Hopper, Wilfred T Tysoe

ACS Chem Biol· February 2025

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A Photoinducible DNA Cross-Linking Agent with Potent Cytotoxicity and Selectivity Toward Triple-Negative Breast Cancer Cell Line.
Qi Zhang, Taufeeque Ali, Thilini Nimasha Fernando Ponnamperumage, Zechao Lin, Nurul Islam Setu, David N Frick

Chem Res Toxicol· January 2025

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JRM-28, a Novel HDAC2 Inhibitor, Upregulates Plasticity-Associated Proteins in Hippocampal Neurons and Enhances Morphological Plasticity via Activation of CREB: Implications for Alzheimer's Disease.
A F M Towheedur Rahman, Sarojini Bulbule, Jawad Bin Belayet, Anna Benko, Carl Gunnar Gottschalk, David N Frick

Cells· November 2024

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Development of a Novel, Small-Molecule Brain-Penetrant Histone Deacetylase Inhibitor That Enhances Spatial Memory Formation in Mice.
Jawad B Belayet, Sarah Beamish, Mizzanoor Rahaman, Samer Alanani, Rajdeep S Virdi, David N Frick, Karyn M Frick

J Med Chem· February 2022

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A transplant recipient's pandemic perspective.
David N Frick

Transpl Infect Dis· October 2021

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Discovery of Drug-Like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3.
Rajdeep S Virdi, Robert V Bavisotto, Nicholas C Hopper, Nemanja Vuksanovic, Trevor R Melkonian, David N Frick

SLAS Discov· December 2020

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Discovery of Drug-like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3.
Rajdeep S Virdi, Robert V Bavisotto, Nicholas C Hopper, Nemanja Vuksanovic, Trevor R Melkonian, David N Frick

bioRxiv· September 2020

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Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3.
David N Frick, Rajdeep S Virdi, Nemanja Vuksanovic, Narayan Dahal, Nicholas R Silvaggi

Biochemistry· July 2020

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Fluorescent probe displacement assays reveal unique nucleic acid binding properties of human nudix enzymes.
Atreyei Ray, David N Frick

Anal Biochem· April 2020

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New Techniques to Study Intracellular Receptors in Living Cells: Insights Into RIG-I-Like Receptor Signaling.
M J Corby, Valerica Raicu, David N Frick

Adv Exp Med Biol· February 2020

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Role of the Conserved DECH-Box Cysteine in Coupling Hepatitis C Virus Helicase-Catalyzed ATP Hydrolysis to RNA Unwinding.
Mark M Yerukhimovich, Christopher C Marohnic, David N Frick

Biochemistry· October 2018

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Quantitative microspectroscopic imaging reveals viral and cellular RNA helicase interactions in live cells.
M J Corby, Michael R Stoneman, Gabriel Biener, Joel D Paprocki, Rajesh Kolli, David N Frick

J Biol Chem· July 2017

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Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV.
Marcella Bassetto, Pieter Leyssen, Johan Neyts, Mark M Yerukhimovich, David N Frick

Bioorg Med Chem Lett· February 2017

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In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase.
Marcella Bassetto, Pieter Leyssen, Johan Neyts, Mark M Yerukhimovich, David N Frick

Eur J Med Chem· January 2017

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Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication.
Marcella Bassetto, Pieter Leyssen, Johan Neyts, Mark M Yerukhimovich, David N Frick

Eur J Med Chem· November 2016

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Bicyclic octahydrocyclohepta[b]pyrrol-4(1H)one derivatives as novel selective anti-hepatitis C virus agents.
Neerja Kaushik-Basu, Nina K Ratmanova, Dinesh Manvar, Dmitry S Belov, Ozge Cevik, David N Frick

Eur J Med Chem· October 2016

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Analysis of the Enzymatic Activity of an NS3 Helicase Genotype 3a Variant Sequence Obtained from a Relapse Patient.
Paola J S Provazzi, Sourav Mukherjee, Alicia M Hanson, Mauricio L Nogueira, Bruno M Carneiro, David N Frick

PLoS One· June 2016

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Discovery of the 2-phenyl-4,5,6,7-Tetrahydro-1H-indole as a novel anti-hepatitis C virus targeting scaffold.
Ivan A Andreev, Dinesh Manvar, Maria Letizia Barreca, Dmitry S Belov, Amartya Basu, David N Frick

Eur J Med Chem· April 2016

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Novel symmetrical phenylenediamines as potential anti-hepatitis C virus agents.
Marcella Bassetto, Salvatore Ferla, Pieter Leyssen, Johan Neyts, Mark M Yerukhimovich, David N Frick

Antivir Chem Chemother· December 2015

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Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy.
Jean Ndjomou, M Josie Corby, Noreena L Sweeney, Alicia M Hanson, Cihan Aydin, David N Frick

ACS Chem Biol· August 2015

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Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase.
Noreena L Sweeney, Alicia M Hanson, Sourav Mukherjee, Jean Ndjomou, Brian J Geiss, David N Frick

ACS Infect Dis· March 2015

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Ebselen inhibits hepatitis C virus NS3 helicase binding to nucleic acid and prevents viral replication.
Sourav Mukherjee, Warren S Weiner, Chad E Schroeder, Denise S Simpson, Alicia M Hanson, David N Frick

ACS Chem Biol· October 2014

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