Publications by authors named "David Hallifax"

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Exploring the Boundaries for In Vitro-In Vivo Extrapolation: Use of Isolated Rat Hepatocytes in Co-culture and Impact of Albumin Binding Properties in the Prediction of Clearance of Various Drug Types.
Laura Francis, Kayode Ogungbenro, Tom De Bruyn, J Brian Houston, David Hallifax

Drug Metab Dispos· November 2023

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Utilising Magnetically Isolated Lysosomes for Direct Quantification of Intralysosomal Drug Concentrations by LC-MS/MS Analysis: An Investigatory Study With Imipramine.
Laura Francis, Andrew Harrell, David Hallifax, Aleksandra Galetin

J Pharm Sci· September 2020

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Importance of the Unstirred Water Layer and Hepatocyte Membrane Integrity In Vitro for Quantification of Intrinsic Metabolic Clearance.
Francesca L Wood, J Brian Houston, David Hallifax

Drug Metab Dispos· March 2018

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Characterization of the comparative drug binding to intra- (liver fatty acid binding protein) and extra- (human serum albumin) cellular proteins.
Andrew Rowland, David Hallifax, Matthew R Nussio, Joseph G Shapter, Peter I Mackenzie

Xenobiotica· June 2016

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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy, Nicola J Hewitt, Ute Albrecht, Melvin E Andersen, Nariman Ansari, David Hallifax

Arch Toxicol· August 2013

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Evaluation of hepatic clearance prediction using in vitro data: emphasis on fraction unbound in plasma and drug ionisation using a database of 107 drugs.
David Hallifax, J Brian Houston

J Pharm Sci· August 2012

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Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs.
David Hallifax, Elisa Turlizzi, Ugo Zanelli, J Brian Houston

Eur J Pharm Sci· April 2012

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Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Ugo Zanelli, Nicola Pasquale Caradonna, David Hallifax, Elisa Turlizzi, J Brian Houston

Drug Metab Dispos· January 2012

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Comparison of intrinsic clearances in human liver microsomes and suspended hepatocytes from the same donor livers: clearance-dependent relationship and implications for prediction of in vivo clearance.
Joanne A Foster, J Brian Houston, David Hallifax

Xenobiotica· February 2011

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Prediction of human metabolic clearance from in vitro systems: retrospective analysis and prospective view.
David Hallifax, Joanne A Foster, J Brian Houston

Pharm Res· October 2010

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Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo.
M Teresa Donato, David Hallifax, Laura Picazo, José V Castell, J Brian Houston

Drug Metab Dispos· September 2010

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Saturable uptake of lipophilic amine drugs into isolated hepatocytes: mechanisms and consequences for quantitative clearance prediction.
David Hallifax, J Brian Houston

Drug Metab Dispos· August 2007

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Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.
Nicola J Hewitt, María José Gómez Lechón, J Brian Houston, David Hallifax, Hayley S Brown

Drug Metab Rev· June 2007

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Uptake and intracellular binding of lipophilic amine drugs by isolated rat hepatocytes and implications for prediction of in vivo metabolic clearance.
David Hallifax, J Brian Houston

Drug Metab Dispos· November 2006

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Prediction of in vivo drug-drug interactions from in vitro data : factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4.
Hayley S Brown, Aleksandra Galetin, David Hallifax, J Brian Houston

Clin Pharmacokinet· November 2006

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Binding of drugs to hepatic microsomes: comment and assessment of current prediction methodology with recommendation for improvement.
David Hallifax, J Brian Houston

Drug Metab Dispos· April 2006

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Prediction of metabolic clearance using cryopreserved human hepatocytes: kinetic characteristics for five benzodiazepines.
David Hallifax, Helen C Rawden, Nancy Hakooz, J Brian Houston

Drug Metab Dispos· December 2005

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CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions.
Aleksandra Galetin, Kiyomi Ito, David Hallifax, J Brian Houston

J Pharmacol Exp Ther· July 2005

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Impact of parallel pathways of drug elimination and multiple cytochrome P450 involvement on drug-drug interactions: CYP2D6 paradigm.
Kiyomi Ito, David Hallifax, R Scott Obach, J Brian Houston

Drug Metab Dispos· June 2005

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Utility of recombinant enzyme kinetics in prediction of human clearance: impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates.
Aleksandra Galetin, Caroline Brown, David Hallifax, Kiyomi Ito, J Brian Houston

Drug Metab Dispos· December 2004

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Quantitative prediction of the in vivo inhibition of diazepam metabolism by omeprazole using rat liver microsomes and hepatocytes.
Hannah M Jones, David Hallifax, J Brian Houston

Drug Metab Dispos· May 2004

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Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo.
Andrew Collett, Jolanta Tanianis-Hughes, David Hallifax, Geoff Warhurst

Pharm Res· May 2004

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