Publications by authors named "David Hickman"

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Safety and immunogenicity of two Tau-targeting active immunotherapies, ACI-35.030 and JACI-35.054, in participants with early Alzheimer's disease: a phase 1b/2a, multicentre, double-blind, randomised, placebo-controlled study.
Olivier Sol, Julien Mermoud, Merja Hallikainen, Sudhir Kurl, Juha Rinne, David T Hickman

EBioMedicine· October 2025

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Correction: An Anti-β-Amyloid vaccine for treating cognitive deficits in a mouse model of down syndrome.
Pavel V Belichenko, Rime Madani, Lorianne Rey-Bellet, Maria Pihlgren, Ann Becker, David T Hickman

PLoS One· May 2025

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Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core.
Heiko Kroth, Felix Oden, Andreia Monica Serra, Jerome Molette, Andre Mueller, David Hickman

Bioorg Med Chem· December 2021

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Lead Optimization Highlights the Importance of Off-Target Assays to Develop a PET Tracer for the Detection of Pathological Aggregated Tau in Alzheimer's Disease and Other Tauopathies.
Heiko Kroth, Felix Oden, Jerome Molette, Hanno Schieferstein, Emanuele Gabellieri, David Hickman

J Med Chem· September 2021

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Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzheimer's disease and other tauopathies.
Emanuele Gabellieri, Francesca Capotosti, Jerome Molette, Nampally Sreenivasachary, Andre Mueller, David Hickman

Eur J Med Chem· October 2020

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Discovery and preclinical characterization of [F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies.
Heiko Kroth, Felix Oden, Jerome Molette, Hanno Schieferstein, Francesca Capotosti, David T Hickman

Eur J Nucl Med Mol Imaging· September 2019

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Novel Phospho-Tau Monoclonal Antibody Generated Using a Liposomal Vaccine, with Enhanced Recognition of a Conformational Tauopathy Epitope.
Clara Theunis, Oskar Adolfsson, Natalia Crespo-Biel, Kasia Piorkowska, Maria Pihlgren, David T Hickman

J Alzheimers Dis· February 2018

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THYROID PHANTOM MEASUREMENTS IN JOINT EURADOS-LLNL INTERCOMPARISON EXERCISE.
David P Hickman, Lori Collins, Didier Franck, Ruth N Harding, Karen L Jeffers

Radiat Prot Dosimetry· January 2018

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Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of β-amyloid-42 aggregation for the treatment of Alzheimer's disease.
Nampally Sreenivasachary, Heiko Kroth, Pascal Benderitter, Anne Hamel, Yvan Varisco, David T Hickman

Bioorg Med Chem Lett· March 2017

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An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome.
Pavel V Belichenko, Rime Madani, Lorianne Rey-Bellet, Maria Pihlgren, Ann Becker, David T Hickman

PLoS One· August 2016

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Engineering amyloid-like assemblies from unstructured peptides via site-specific lipid conjugation.
María Pilar López Deber, David T Hickman, Deepak Nand, Marc Baldus, Andrea Pfeifer

PLoS One· May 2015

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Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy.
Clara Theunis, Natalia Crespo-Biel, Valérie Gafner, Maria Pihlgren, María Pilar López-Deber, David T Hickman

PLoS One· January 2015

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Historical review of lung counting efficiencies for low energy photon emitters.
Karen L Jeffers, David P Hickman

Health Phys· March 2014

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Dynamic nuclear polarization NMR spectroscopy: revealing multiple conformations in lipid-anchored peptide vaccines.
Eline J Koers, Maria Pilar López-Deber, Markus Weingarth, Deepak Nand, David T Hickman

Angew Chem Int Ed Engl· October 2013

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TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice.
Maria Pihlgren, Alberto B Silva, Rime Madani, Valérie Giriens, Ying Waeckerle-Men, David T Hickman

Blood· January 2013

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Linear dimensions and volumes of human lungs.
David P Hickman

Health Phys· August 2012

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Natural vs. artificial anthropometric phantoms for measuring bone-seeking radionuclides.
Henry Spitz, Samuel Glover, David Hickman

Health Phys· March 2012

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Sequence-independent control of peptide conformation in liposomal vaccines for targeting protein misfolding diseases.
David T Hickman, María Pilar López-Deber, Dorin Mlaki Ndao, Alberto B Silva, Deepak Nand

J Biol Chem· April 2011

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A calibration phantom for direct, in vivo measurement of 241Am in the axillary lymph nodes.
Rachel Zeman, Megan Lobaugh, Henry Spitz, Samuel Glover, David Hickman

Health Phys· September 2009

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Immunization with liposome-anchored pegylated peptides modulates doxorubicin sensitivity in P-glycoprotein-expressing P388 cells.
Grégory Gatouillat, Johann Odot, Emilie Balasse, Claude Nicolau, Pierre-François Tosi, David T Hickman

Cancer Lett· November 2007

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Mapping mandibular rest in humans utilizing electromyographic patterns from masticatory muscles.
David M Hickman, William Stauber

Cranio· October 2007

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Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice.
Andreas Muhs, David T Hickman, Maria Pihlgren, Nathalie Chuard, Valérie Giriens

Proc Natl Acad Sci U S A· June 2007

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Telehealth screen for depression in a chronic illness care management program.
Carolyn L Turvey, Deborah Willyard, David H Hickman, Dawn M Klein, Oladipo Kukoyi

Telemed J E Health· February 2007

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DyNAs: constitutional dynamic nucleic acid analogues.
Nampally Sreenivasachary, David T Hickman, Dominique Sarazin, Jean-Marie Lehn

Chemistry· November 2006

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Techniques for reducing anesthetic injection pain: an interdisciplinary survey of knowledge and application.
Scott S Meit, Van Yasek, C Ken Shannon, David Hickman, Dorian Williams

J Am Dent Assoc· September 2004

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