Publications by authors named "David Hoke"

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Prostate cancer risk-associated single-nucleotide polymorphisms impact the conformational dynamics of prostate-specific antigen.
Srilakshmi Srinivasan, Brooke K Hayes, Mauricio G S Costa, Blake T Riley, Emily Wilson, David E Hoke

BMC Biol· December 2025

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Structure and dynamics of GAD65 in complex with an autoimmune polyendocrine syndrome type 2-associated autoantibody.
Susanne H D Ständer, Cyril F Reboul, Sarah N Le, Daniel E Williams, Peter G Chandler, David E Hoke

Nat Commun· March 2025

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Mutational and biophysical robustness in a prestabilized monobody.
Peter G Chandler, Li Lynn Tan, Benjamin T Porebski, James S Green, Blake T Riley, David E Hoke

J Biol Chem· August 2021

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Structural Studies of Thyroid Peroxidase Show the Monomer Interacting With Autoantibodies in Thyroid Autoimmune Disease.
Daniel E Williams, Sarah N Le, David E Hoke, Peter G Chandler, Monika Gora

Endocrinology· February 2020

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Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif.
Xingchen Chen, Blake T Riley, Simon J de Veer, David E Hoke, Jessica Van Haeften

PLoS One· October 2019

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Crystal structure of the inhibitor-free form of the serine protease kallikrein-4.
Blake T Riley, David E Hoke, Sheena McGowan, Ashley M Buckle

Acta Crystallogr F Struct Biol Commun· August 2019

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KLK4 Inhibition by Cyclic and Acyclic Peptides: Structural and Dynamical Insights into Standard-Mechanism Protease Inhibitors.
Blake T Riley, Olga Ilyichova, Simon J de Veer, Joakim E Swedberg, Emily Wilson, David E Hoke

Biochemistry· May 2019

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Reactive centre loop dynamics and serpin specificity.
Emilia M Marijanovic, James Fodor, Blake T Riley, Benjamin T Porebski, Mauricio G S Costa, David E Hoke

Sci Rep· March 2019

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Thyroid Peroxidase as an Autoantigen in Hashimoto's Disease: Structure, Function, and Antigenicity.
Daniel E Williams, Sarah N Le, Marlena Godlewska, David E Hoke, Ashley M Buckle

Horm Metab Res· December 2018

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Incorporation of Homochirality into a Zeolitic Imidazolate Framework Membrane for Efficient Chiral Separation.
Jun Yong Chan, Huacheng Zhang, Yada Nolvachai, Yaoxin Hu, Haijin Zhu, David E Hoke

Angew Chem Int Ed Engl· December 2018

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Genetic variation affecting DNA methylation and the human imprinting disorder, Beckwith-Wiedemann syndrome.
Vinod Dagar, Wendy Hutchison, Andrea Muscat, Anita Krishnan, David Hoke

Clin Epigenetics· August 2018

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Circumventing the stability-function trade-off in an engineered FN3 domain.
Benjamin T Porebski, Paul J Conroy, Nyssa Drinkwater, Peter Schofield, Rodrigo Vazquez-Lombardi, David E Hoke

Protein Eng Des Sel· November 2016

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Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics.
Blake T Riley, Olga Ilyichova, Mauricio G S Costa, Benjamin T Porebski, Simon J de Veer, David E Hoke

Sci Rep· October 2016

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Smoothing a rugged protein folding landscape by sequence-based redesign.
Benjamin T Porebski, Shani Keleher, Jeffrey J Hollins, Adrian A Nickson, Emilia M Marijanovic, David E Hoke

Sci Rep· September 2016

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Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity.
Sarah N Le, Benjamin T Porebski, Julia McCoey, James Fodor, Blake Riley, David E Hoke

PLoS One· June 2016

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Structural and dynamic properties that govern the stability of an engineered fibronectin type III domain.
Benjamin T Porebski, Adrian A Nickson, David E Hoke, Morag R Hunter, Liguang Zhu

Protein Eng Des Sel· March 2015

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An ortholog of the Leptospira interrogans lipoprotein LipL32 aids in the colonization of Pseudoalteromonas tunicata to host surfaces.
Melissa Gardiner, David E Hoke, Suhelen Egan

Front Microbiol· July 2014

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Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis.
Itamar Kass, David E Hoke, Mauricio G S Costa, Cyril F Reboul, Benjamin T Porebski

Proc Natl Acad Sci U S A· June 2014

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Free to choose but liable for the consequences: should non-vaccinators be penalized for the harm they do?
Arthur L Caplan, David Hoke, Nicholas J Diamond, Viktoriya Karshenboyem

J Law Med Ethics· November 2013

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Leptospiral LruA is required for virulence and modulates an interaction with mammalian apolipoprotein AI.
Kunkun Zhang, Gerald L Murray, Torsten Seemann, Amporn Srikram, Thanatchaporn Bartpho, David E Hoke

Infect Immun· October 2013

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Screening of 71 P. multocida proteins for protective efficacy in a fowl cholera infection model and characterization of the protective antigen PlpE.
Tamás Hatfaludi, Keith Al-Hasani, Lan Gong, John D Boyce, Mark Ford, David E Hoke

PLoS One· March 2013

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Membrane proteins of Pseudoalteromonas tunicata during the transition from planktonic to extracellular matrix-adherent state.
David E Hoke, Kunkun Zhang, Suhelen Egan, Tamas Hatfaludi, Ashley M Buckle

Environ Microbiol Rep· June 2011

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An analysis of the cross-reactivity of autoantibodies to GAD65 and GAD67 in diabetes.
Bindu Jayakrishnan, David E Hoke, Christopher G Langendorf, Ashley M Buckle, Merrill J Rowley

PLoS One· April 2011

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Cross-protective immunity against leptospirosis elicited by a live, attenuated lipopolysaccharide mutant.
Amporn Srikram, Kunkun Zhang, Thanatchaporn Bartpho, Miranda Lo, David E Hoke

J Infect Dis· March 2011

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Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate.
Michael Ho, David E Hoke, Yee Jia Chua, Qiao-Xin Li, Janetta G Culvenor

Int J Alzheimers Dis· December 2010

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