Publications by authors named "David Housman"

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A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy.
Katherine R Croce, Christopher Ng, Serihy Pankiv, Eddy Albarran, Peter Langfelder, David E Housman

Neuron· November 2025

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CellPHIE: Integrating Pathway Discovery With Pooled Profiling of Perturbations Uncovers Pathways of Huntington's Disease, Including Genetic Modifiers of Neuronal Development and Morphology.
Byunguk Kang, Michael Murphy, Christopher W Ng, Matthew Joseph Leventhal, Nhan Huynh, David E Housman

bioRxiv· May 2025

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CD4 T cells restricted to DRB1*15:01 recognize two Epstein-Barr virus glycoproteins capable of intracellular antigen presentation.
Natalia Drosu, Monique Anderson, Philippe A Bilodeau, Shuhei Nishiyama, Takahisa Mikami, David Housman

Proc Natl Acad Sci U S A· October 2024

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Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins.
Gianna M Fote, Vinay V Eapen, Ryan G Lim, Clinton Yu, Lisa Salazar, David E Housman

Proc Natl Acad Sci U S A· August 2024

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Multi-omic analysis of Huntington's disease reveals a compensatory astrocyte state.
Fahad Paryani, Ji-Sun Kwon, Christopher W Ng, Kelly Jakubiak, Nacoya Madden, David E Housman

Nat Commun· August 2024

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Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis.
Gino B Ferraro, Ahmed Ali, Alba Luengo, David P Kodack, Amy Deik, David E Housman

Nat Cancer· November 2021

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CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors.
Jill R Crittenden, Shenyu Zhai, Magdalena Sauvage, Takashi Kitsukawa, Eric Burguière, David E Housman

Neurobiol Dis· October 2021

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Striatal transcriptome changes linked to drug-induced repetitive behaviors.
Jill R Crittenden, Theresa A Gipson, Anne C Smith, Hilary A Bowden, Ferah Yildirim, David E Housman

Eur J Neurosci· April 2021

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FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS.
Gino B Ferraro, Ahmed Ali, Alba Luengo, David P Kodack, Amy Deik, David E Housman

Nat Cancer· April 2021

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Tenofovir prodrugs potently inhibit Epstein-Barr virus lytic DNA replication by targeting the viral DNA polymerase.
Natalia C Drosu, Elazer R Edelman, David E Housman

Proc Natl Acad Sci U S A· June 2020

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Early epigenomic and transcriptional changes reveal Elk-1 transcription factor as a therapeutic target in Huntington's disease.
Ferah Yildirim, Christopher W Ng, Vincent Kappes, Tobias Ehrenberger, Siobhan K Rigby, David E Housman

Proc Natl Acad Sci U S A· December 2019

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IKKβ slows Huntington's disease progression in R6/1 mice.
Joseph Ochaba, Gianna Fote, Marketta Kachemov, Soe Thein, Sylvia Y Yeung, David E Housman

Proc Natl Acad Sci U S A· May 2019

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Transcriptome alterations in myotonic dystrophy skeletal muscle and heart.
Eric T Wang, Daniel Treacy, Katy Eichinger, Adam Struck, Joseph Estabrook, David Housman

Hum Mol Genet· April 2019

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Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction.
Samir R Nath, Zhigang Yu, Theresa A Gipson, Gregory B Marsh, Eriko Yoshidome, David E Housman

J Clin Invest· August 2018

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Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.
Pietro Fratta, Prasanth Sivakumar, Jack Humphrey, Kitty Lo, Thomas Ricketts, David E Housman

EMBO J· June 2018

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Could antiretrovirals be treating EBV in MS? A case report.
Natalia C Drosu, Elazer R Edelman, David E Housman

Mult Scler Relat Disord· May 2018

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Detection of long repeat expansions from PCR-free whole-genome sequence data.
Egor Dolzhenko, Joke J F A van Vugt, Richard J Shaw, Mitchell A Bekritsky, Marka van Blitterswijk, David E Housman

Genome Res· November 2017

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HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington's disease mouse models.
Andreas Neueder, Theresa A Gipson, Sophie Batterton, Hayley J Lazell, Pamela P Farshim, David E Housman

Sci Rep· October 2017

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A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA) Repeats Associated with Friedreich's Ataxia.
Ryan J McGinty, Franco Puleo, Anna Y Aksenova, Julia A Hisey, Alexander A Shishkin, David E Housman

Cell Rep· September 2017

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Genome Sequencing Technologies and Nursing: What Are the Roles of Nurses and Nurse Scientists?
Jacquelyn Y Taylor, Michelle L Wright, Kathleen T Hickey, David E Housman

Nurs Res· May 2017

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Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits.
Ryan G Lim, Chris Quan, Andrea M Reyes-Ortiz, Sarah E Lutz, Amanda J Kedaigle, David E Housman

Cell Rep· May 2017

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Striosome-dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons.
Jill R Crittenden, Paul W Tillberg, Michael H Riad, Yasuyuki Shima, Charles R Gerfen, David E Housman

Proc Natl Acad Sci U S A· October 2016

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Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features.
Qing Ouyang, Tojo Nakayama, Ozan Baytas, Shawn M Davidson, Chendong Yang, David E Housman

Proc Natl Acad Sci U S A· September 2016

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Lead toxicity and genetics in Flint, MI.
Jacquelyn Y Taylor, Michelle L Wright, David Housman

NPJ Genom Med· June 2016

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A perspective for sequencing familial hypercholesterolaemia in African Americans.
Michelle L Wright, David Housman, Jacquelyn Y Taylor

NPJ Genom Med· May 2016

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