Publications by authors named "David K Finlay"

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Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function.
Benjamin J Jenkins, Yasmin R Jenkins, Fernando M Ponce-Garcia, Chloe Moscrop, Iain A Perry, David K Finlay

Nat Commun· November 2025

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Dietary lipid overload creates a suppressive environment that impedes the antiviral functions of NK cells.
Simone Schimmer, Leonie Kerkmann, Nele Kahlert, Shahd Al Jubeh, Tanja Werner, David K Finlay

iScience· May 2025

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ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity.
Benjamin J Jenkins, Yasmin R Jenkins, Fernando M Ponce-Garcia, Chloe Moscrop, Iain A Perry, David K Finlay

bioRxiv· March 2025

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Natural killer loops: pyruvate in, lactate out.
Cathal Keane, David K Finlay

Nat Metab· February 2025

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La dolce vita: fueling chimeric antigen receptor (CAR) T cells with Glut1 to improve therapeutic efficacy.
Karen Slattery, David K Finlay, Phillip K Darcy

Immunometabolism (Cobham)· January 2025

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Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level.
Carrie Corkish, Cristhiane Favero Aguiar, David K Finlay

Nat Commun· November 2024

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Oxidative stress in gut T17 cells makes mice susceptible to bacterial infection.
Simon O'Shaughnessy, David K Finlay

Immunometabolism (Cobham)· October 2024

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Iron Is Critical for Mucosal-Associated Invariant T Cell Metabolism and Effector Functions.
Eimear K Ryan, Christy Clutter, Conor De Barra, Benjamin J Jenkins, Simon O'Shaughnessy, David K Finlay

J Immunol· June 2024

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Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans.
Barry Scott, Emily A Day, Katie L O'Brien, John Scanlan, Grace Cromwell, David K Finlay

Nat Metab· April 2024

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Fatty acids are crucial to fuel NK cells upon acute retrovirus infection.
Simone Schimmer, Daniela Mittermüller, Tanja Werner, Paul E Görs, Sven W Meckelmann, David K Finlay

Front Immunol· December 2023

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QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations.
Leonard R Pelgrom, Gavin M Davis, Simon O'Shaughnessy, Emilie J M Wezenberg, Sander I Van Kasteren, David K Finlay

Cell Rep· August 2023

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Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity.
Benjamin J Jenkins, Julianna Blagih, Fernando M Ponce-Garcia, Mary Canavan, Nancy Gudgeon, David K Finlay

Cell Metab· July 2023

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The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing.
Mariana P Cervantes-Silva, Richard G Carroll, Mieszko M Wilk, Diana Moreira, Cloe A Payet, David K Finlay

Nat Commun· December 2022

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The Circadian Clock Protein BMAL1 Acts as a Metabolic Sensor In Macrophages to Control the Production of Pro IL-1β.
George A Timmons, Richard G Carroll, James R O'Siorain, Mariana P Cervantes-Silva, Lauren E Fagan, David K Finlay

Front Immunol· January 2022

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Cytokine-induced natural killer cell training is dependent on cellular metabolism and is defective in obesity.
Nidhi Kedia-Mehta, Laura Tobin, Vanessa Zaiatz-Bittencourt, Marta M Pisarska, Conor De Barra, David K Finlay

Blood Adv· November 2021

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Metabolic requirements of NK cells during the acute response against retroviral infection.
Elisabeth Littwitz-Salomon, Diana Moreira, Joe N Frost, Chloe Choi, Kevin T Liou, David K Finlay

Nat Commun· September 2021

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Specific human cytomegalovirus signature detected in NK cell metabolic changes post vaccination.
Elena Woods, Vanessa Zaiatz-Bittencourt, Ciaran Bannan, Colm Bergin, David K Finlay

NPJ Vaccines· September 2021

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Optimising NK cell metabolism to increase the efficacy of cancer immunotherapy.
Chloe Choi, David K Finlay

Stem Cell Res Ther· June 2021

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Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages.
Jennifer K Dowling, Remsha Afzal, Linden J Gearing, Mariana P Cervantes-Silva, Stephanie Annett, David K Finlay

Nat Commun· March 2021

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TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer.
Karen Slattery, Elena Woods, Vanessa Zaiatz-Bittencourt, Sam Marks, Sonya Chew, David K Finlay

J Immunother Cancer· February 2021

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Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation.
Nicholas Jones, Julianna Blagih, Fabio Zani, April Rees, David G Hill, David K Finlay

Nat Commun· February 2021

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De novo polyamine synthesis supports metabolic and functional responses in activated murine NK cells.
Katie L O'Brien, Nadine Assmann, Eimear O'Connor, Cathal Keane, Jessica Walls, David K Finlay

Eur J Immunol· January 2021

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Diverse Immunoregulatory Roles of Oxysterols-The Oxidized Cholesterol Metabolites.
Chloe Choi, David K Finlay

Metabolites· September 2020

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Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses.
Jessica F Walls, Jeff J Subleski, Erika M Palmieri, Marieli Gonzalez-Cotto, Clair M Gardiner, David K Finlay

Elife· August 2020

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