Publications by authors named "David L Mack"

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Dystrophin Loss in Engineered Heart Tissues Recapitulates Clinically Relevant Aspects of Dystrophic Cardiomyopathy.
Alex J Goldstein, Thomas P Leahy, David L Mack, Nathan J Sniadecki

J Biomech Eng· February 2026

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Myosin inhibition partially rescues the myofiber proteome in X-linked myotubular myopathy.
Elise Gerlach Melhedegaard, Fanny Rostedt, Charlotte Gineste, Robert Ae Seaborne, Hannah F Dugdale, David L Mack

JCI Insight· December 2025

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Direct cell reprogramming by a designed agonist inducing HER2-FGFR proximity.
Riya Keshri, Marc Exposit, Mohamad Abedi, Derrick R Hicks, Zachary Foreman, David L Mack

bioRxiv· October 2025

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Bioengineered Human Cardiac Ventricular Model with Transmural Helical Remodeling.
Nisa P Williams, Kevin M Beussman, John R Foster, Marcus Rhodehamel, Charles A Williams, David L Mack

Adv Healthc Mater· August 2025

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Monitoring in real time and far-red imaging of HO dynamics with subcellular resolution.
Justin Daho Lee, Amanda Nguyen, Chelsea E Gibbs, Zheyu Ruby Jin, Yuxuan Wang, David L Mack

Nat Chem Biol· April 2025

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Sustained Release of HIF-2α Inhibitors Using Biodegradable Porous Silicon Carriers for Enhanced Immunogenic Cell Death of Malignant Merkel Cell Carcinoma.
Juyoung Seong, Minju Kim, Jounghyun Yoo, David L Mack, Jung Hyun Lee

ACS Appl Mater Interfaces· February 2025

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An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing.
Jacob W Fleming, Molly C McCloskey, Kevin Gray, David R Nash, Vincent Leung, David L Mack

Curr Res Toxicol· January 2025

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Uncovering the Embryonic Origins of Duchenne Muscular Dystrophy.
Philip Barrett, Ke'ale W Louie, Jean-Baptiste Dupont, David L Mack, Lisa Maves

WIREs Mech Dis· November 2024

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Current insights in ultra-rare adenylosuccinate synthetase 1 myopathy - meeting report on the First Clinical and Scientific Conference. 3 June 2024, National Centre for Advancing Translational Science, Rockville, Maryland, the United States of America.
Emma Rybalka, Hyung Jun Park, Atchayaram Nalini, Dipti Baskar, Kiran Polavarapu, David L Mack

Orphanet J Rare Dis· November 2024

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High mobility group box 1 (HMGB1) is a potential disease biomarker in cell and mouse models of Duchenne muscular dystrophy.
Rebecca A Slick, Jessica Sutton, Margaret Haberman, Benjamin S O'Brien, Jennifer A Tinklenberg, David L Mack

Biol Open· September 2024

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Engineered Heart Tissues for Standard 96-Well Tissue Culture Plates.
Alex J Goldstein, Ruby M Padgett, Samantha B Bremner, Ty Higashi, Ava M Obenaus, David L Mack

Methods Mol Biol· July 2024

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Dystrophin deficiency impairs cell junction formation during embryonic myogenesis from pluripotent stem cells.
Elise Mozin, Emmanuelle Massouridès, Virginie Mournetas, Clémence Lièvre, Audrey Bourdon, David L Mack

iScience· July 2024

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YAP dysregulation triggers hypertrophy by CCN2 secretion and TGFβ uptake in human pluripotent stem cell-derived cardiomyocytes.
Orlando Chirikian, Mohamed A Faynus, Markus Merk, Zachary Singh, Christopher Muray, David L Mack

bioRxiv· June 2024

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Incomplete-penetrant hypertrophic cardiomyopathy G256E mutation causes hypercontractility and elevated mitochondrial respiration.
Soah Lee, Alison S Vander Roest, Cheavar A Blair, Kerry Kao, Samantha B Bremner, David L Mack

Proc Natl Acad Sci U S A· May 2024

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Dystrophin deficiency impairs cell junction formation during embryonic myogenesis.
Elise Mozin, Emmanuelle Massouridès, Virginie Mournetas, Clémence Lièvre, Audrey Bourdon, David L Mack

bioRxiv· April 2024

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Human Motor Neurons Elicit Pathological Hallmarks of ALS and Reveal Potential Biomarkers of the Disease in Response to Prolonged IFNγ Exposure.
Changho Chun, Jung Hyun Lee, Mark Bothwell, Paul Nghiem, Alec S T Smith, David L Mack

J Neurosci· April 2024

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Structure-guided engineering of a fast genetically encoded sensor for real-time HO monitoring.
Justin Daho Lee, Woojin Won, Kandace Kimball, Yihan Wang, Fred Yeboah, David L Mack

bioRxiv· February 2024

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Corrigendum: Calcium handling maturation and adaptation to increased substrate stiffness in human iPSC-derived cardiomyocytes: the impact of full-length dystrophin deficiency.
Josè Manuel Pioner, Lorenzo Santini, Chiara Palandri, Marianna Langione, Bruno Grandinetti, David L Mack

Front Physiol· June 2023

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ACTA1 H40Y mutant iPSC-derived skeletal myocytes display mitochondrial defects in an in vitro model of nemaline myopathy.
Melanie Gartz, Margaret Haberman, Jessica Sutton, Rebecca A Slick, Shawn M Luttrell, David L Mack

Exp Cell Res· March 2023

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Calcium handling maturation and adaptation to increased substrate stiffness in human iPSC-derived cardiomyocytes: The impact of full-length dystrophin deficiency.
Josè Manuel Pioner, Lorenzo Santini, Chiara Palandri, Marianna Langione, Bruno Grandinetti, David L Mack

Front Physiol· November 2022

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Editorial: Modeling neuromuscular diseases to determine molecular drivers of pathology and for drug discovery.
Alec S T Smith, Megan L McCain, Mark Bothwell, David L Mack

Front Cell Dev Biol· October 2022

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High-throughput, real-time monitoring of engineered skeletal muscle function using magnetic sensing.
Alec St Smith, Shawn M Luttrell, Jean-Baptiste Dupont, Kevin Gray, Daniel Lih, David L Mack

J Tissue Eng· September 2022

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Full-length dystrophin deficiency leads to contractile and calcium transient defects in human engineered heart tissues.
Samantha B Bremner, Christian J Mandrycky, Andrea Leonard, Ruby M Padgett, Alan R Levinson, David L Mack

J Tissue Eng· August 2022

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A Change of Heart: Human Cardiac Tissue Engineering as a Platform for Drug Development.
Samantha B Bremner, Karen S Gaffney, Nathan J Sniadecki, David L Mack

Curr Cardiol Rep· May 2022

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Differentiation Capacity of Human Urine-Derived Stem Cells to Retain Telomerase Activity.
Yingai Shi, Guihua Liu, Rongpei Wu, David L Mack, Xiuzhi Susan Sun

Front Cell Dev Biol· May 2022

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